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| UPDATE: September 2000 | MW: N/R | MF: N/R |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
skin | rat
lowest published toxic dose: 600 mg/kg (1-20 day pregnant)
|
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetal death
TIHEEC 5,587,1989
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skin | rat
lowest published toxic dose: 600 mg/kg (1-20 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
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TIHEEC 5,587,1989
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
skin | mouse
lowest published toxic dose: 7 mL/kg/14 week- intermittent
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Tumorigenic: Tumors at site of application Skin and Appendages: Tumors
NTIS** OTS0536234
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
oral | rat
lethal dose (50 percent kill): 4,300 mg/kg
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Behavioral: Somnolence (general depressed activity) | Gastrointestinal: Hypermotility, diarrhea
ATDAEI 1,136,1990
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skin | rabbit
lethal dose : >2 gm/kg
|
N/R
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ATDAEI 1,136,1990
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
skin | mouse
lowest published toxic dose: 50 gm/kg/10 week- intermittent
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Liver: Hepatitis (hepatocellular necrosis), diffuse | Liver: Changes in liver weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 14,189,1994
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skin | rat
lowest published toxic dose: 8,125 mg/kg/13 week- intermittent
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Liver: Hepatitis (hepatocellular necrosis), diffuse | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 6,240,1986
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skin | rabbit
lowest published toxic dose: 2,400 mg/kg/28 day- intermittent
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Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change | Liver: Changes in liver weight Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0539440
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REVIEWS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
N/R
|
N/R
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N/R
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| ||
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
N/R
|
N/R
|
N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
|
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REFERENCE
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: X1881 |
 ;Number of Industries 3; Total Number of Facilities 121; Number of Occupations 6; Total Number of Employees Exposed 8,884; Total Number of Female Employees Exposed 239 | |||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA Section 8(e) Risk Notification, 8EHQ-0393-8763
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
ATDAEI
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Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert,
Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
|
TIHEEC
|
Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ
08540) V.1- 1985-
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TOXID9
|
Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
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