The Registry of Toxic Effects of Chemical Substances

Coal tar

RTECS #: GF8600000

CAS #: 8007-45-2

UPDATE: August 2007 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Carbo - cort
  2. Coal tar, aerosol
  3. Coal tar solution USP
  4. Crude coal tar
  5. Estar (skin treatment)
  6. Impervotar
  7. KC 261
  8. Lavatar
  1. Picis carbonis
  2. Pixalbol
  3. Polytar bath
  4. Supertah
  5. Syntar
  6. Tar, coal
  7. Zetar


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		15 µg/3 day- intermittent mild 85DKA8 -,127,1977
skin
rabbit 		5%/3 hour mild SCPHA4 43,11,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium 		63 mg/kg SWEHDO 12,137,1986
DNA adduct skin
mouse 		240 mg/kg CRNGDP 9,1253,1988
DNA adduct skin
mouse 		19.2 mg/kg/24 hour TOXID9 72(Supp 1),325,2003
DNA adduct skin
mouse 		3,600 mg/kg/9 day TOXID9 60,104,2001
DNA damage skin
mouse 		25 pph MUREAV 468,117,2000
mutation in microorganisms Escherichia coli 50 µg/plate (+enzymatic activation step) NTIS** PB84-138973
mutation in microorganisms Salmonella typhimurium 5 µg/plate (+enzymatic activation step) NTIS** PB84-138973
gene conversion and mitotic recombination Saccharomyes cerevisiae 100 ppm NTIS** PB84-138973
mutation in mammalian somatic cells skin
mouse 		100 pph MUREAV 468,117,2000
other mutation test systems skin
human 		5,000 ppm 26UYA8 -,335,1971


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 22 gm/m3/55 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		JNCIAM 39,175,1967
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/90 day- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** AD-A041-973
oral
mouse 		lowest published toxic dose: 12 gm/kg/30 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		AJCAA7 26,552,1936
skin
mouse 		lowest published toxic dose: 64 gm/kg/36 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		AMIHBC 4,299,1951
skin
mouse 		toxic dose : 8,400 mg/kg/64 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		ADMFAU 242,176,1972


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		lethal dose (50 percent kill): >7,950 mg/kg N/R ENTOX* -,628,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 35,83,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 35,83,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 34,65,1984
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 34,65,1984
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 3,22,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 3,22,1973
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,175,1987
TOXICOLOGY REVIEW
85CVA2 5,63,1970
TOXICOLOGY REVIEW
ZHPMAT 166,113,1978
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
PAASAH 54,171,1959
TOXICOLOGY REVIEW
ENTOX* -,628,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - FRANCE VME 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Carcinogen, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO COAL TAR-air Carcinogen;
10 hour time-weighted average 0.1 mg/m3 		NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3773;
Number of Industries 2;
Total Number of Facilities 117;
Number of Occupations 3;
Total Number of Employees Exposed 852;
Total Number of Female Employees Exposed 739


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121024/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
26UYA8 "Psoriasis, Proceedings of the International Symposium, Stanford, CA, 1971," Farber, E.M., and A.J. Cox, eds., Stanford, CA, Stanford Univ. Press, 1971
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
ADMFAU Archiv fuer Dermatologische Forschung. (Berlin, Ger.) V.240-252, 1971-75. For publisher information, see ADREDL.
AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40. For publisher information, see CNREA8.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAASAH Publication of the American Association for the Advancement of Science. (Washington, DC) No.1-94, 1934-73. Discontinued.
SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930-
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B: Hygiene, Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed. Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC.

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

ALT CAS #: 8050-41-7
ALT CAS #: 8055-92-3
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