RTECS:GF8600000 The Registry of Toxic Effects of Chemical Substances

Coal tar

RTECS #: GF8600000

CAS #: 8007-45-2

UPDATE: August 2007 MW: N/R MF: N/R

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

MUTATION DATA:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Carbo - cort

Coal tar, aerosol

Coal tar solution USP

Crude coal tar

Estar (skin treatment)

Impervotar

KC 261

Lavatar

Picis carbonis

Pixalbol

Polytar bath

Supertah

Syntar

Tar, coal

Zetar

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
human 15 痢/3 day- intermittent mild 85DKA8 -,127,1977
skin
rabbit 5%/3 hour mild SCPHA4 43,11,1975

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium 63 mg/kg SWEHDO 12,137,1986
DNA adduct skin
mouse 240 mg/kg CRNGDP 9,1253,1988
DNA adduct skin
mouse 19.2 mg/kg/24 hour TOXID9 72(Supp 1),325,2003
DNA adduct skin
mouse 3,600 mg/kg/9 day TOXID9 60,104,2001
DNA damage skin
mouse 25 pph MUREAV 468,117,2000
mutation in microorganisms Escherichia coli 50 痢/plate (+enzymatic activation step) NTIS PB84-138973
mutation in microorganisms Salmonella typhimurium 5 痢/plate (+enzymatic activation step) NTIS PB84-138973
gene conversion and mitotic recombination Saccharomyes cerevisiae 100 ppm NTIS PB84-138973
mutation in mammalian somatic cells skin
mouse 100 pph MUREAV 468,117,2000
other mutation test systems skin
human 5,000 ppm 26UYA8 -,335,1971

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lowest published toxic concentration: 22 gm/m³/55 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors JNCIAM 39,175,1967
inhalation
rat lowest published toxic concentration: 10 mg/m³/90 day- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors NTIS AD-A041-973
oral
mouse lowest published toxic dose: 12 gm/kg/30 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors AJCAA7 26,552,1936
skin
mouse lowest published toxic dose: 64 gm/kg/36 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application AMIHBC 4,299,1951
skin
mouse toxic dose : 8,400 mg/kg/64 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application ADMFAU 242,176,1972

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
rabbit lethal dose (50 percent kill): >7,950 mg/kg N/R ENTOX* -,628,2005

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 35,83,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 35,83,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 34,65,1984
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 34,65,1984
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 3,22,1973
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 3,22,1973
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,175,1987
TOXICOLOGY REVIEW
85CVA2 5,63,1970
TOXICOLOGY REVIEW
ZHPMAT 166,113,1978
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
PAASAH 54,171,1959
TOXICOLOGY REVIEW
ENTOX* -,628,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 mg/m³, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m³, Carcinogen, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO COAL TAR-air Carcinogen;
10 hour time-weighted average 0.1 mg/m³ NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3773;
Number of Industries 2;
Total Number of Facilities 117;
Number of Occupations 3;
Total Number of Employees Exposed 852;
Total Number of Female Employees Exposed 739

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS PB/97/121024/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen

REFERENCES:
CODEN
REFERENCE**

26UYA8 "Psoriasis, Proceedings of the International Symposium, Stanford, CA, 1971," Farber, E.M., and A.J. Cox, eds., Stanford, CA, Stanford Univ. Press, 1971
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
ADMFAU Archiv fuer Dermatologische Forschung. (Berlin, Ger.) V.240-252, 1971-75. For publisher information, see ADREDL.
AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40. For publisher information, see CNREA8.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAASAH Publication of the American Association for the Advancement of Science. (Washington, DC) No.1-94, 1934-73. Discontinued.
SCPHA4 Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930-
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
ZHPMAT Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B: Hygiene, Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed. Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC.

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

ALT CAS #: 8050-41-7
ALT CAS #: 8055-92-3
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SYNONYMS:
Carbo - cort Coal tar, aerosol Coal tar solution USP Crude coal tar Estar (skin treatment) Impervotar KC 261 Lavatar	Picis carbonis Pixalbol Polytar bath Supertah Syntar Tar, coal Zetar

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
skin human	15 痢/3 day- intermittent	mild	85DKA8 -,127,1977
skin rabbit	5%/3 hour	mild	SCPHA4 43,11,1975

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
body fluid assay	rat Salmonella typhimurium	63 mg/kg	SWEHDO 12,137,1986
DNA adduct	skin mouse	240 mg/kg	CRNGDP 9,1253,1988
DNA adduct	skin mouse	19.2 mg/kg/24 hour	TOXID9 72(Supp 1),325,2003
DNA adduct	skin mouse	3,600 mg/kg/9 day	TOXID9 60,104,2001
DNA damage	skin mouse	25 pph	MUREAV 468,117,2000
mutation in microorganisms	Escherichia coli	50 痢/plate (+enzymatic activation step)	NTIS** PB84-138973
mutation in microorganisms	Salmonella typhimurium	5 痢/plate (+enzymatic activation step)	NTIS** PB84-138973
gene conversion and mitotic recombination	Saccharomyes cerevisiae	100 ppm	NTIS** PB84-138973
mutation in mammalian somatic cells	skin mouse	100 pph	MUREAV 468,117,2000
other mutation test systems	skin human	5,000 ppm	26UYA8 -,335,1971

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mouse	lowest published toxic concentration: 22 gm/m³/55 week- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors	JNCIAM 39,175,1967
inhalation rat	lowest published toxic concentration: 10 mg/m³/90 day- continuous	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors	NTIS** AD-A041-973
oral mouse	lowest published toxic dose: 12 gm/kg/30 week- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors	AJCAA7 26,552,1936
skin mouse	lowest published toxic dose: 64 gm/kg/36 week- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application	AMIHBC 4,299,1951
skin mouse	toxic dose : 8,400 mg/kg/64 week- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application	ADMFAU 242,176,1972

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
skin rabbit	lethal dose (50 percent kill): >7,950 mg/kg	N/R	ENTOX* -,628,2005

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review	Animal Sufficient Evidence	IMEMDT 35,83,1985
International Agency for Research on Cancer (IARC) Cancer Review	Human Sufficient Evidence	IMEMDT 35,83,1985
International Agency for Research on Cancer (IARC) Cancer Review	Human Sufficient Evidence	IMEMDT 34,65,1984
International Agency for Research on Cancer (IARC) Cancer Review	Animal Sufficient Evidence	IMEMDT 34,65,1984
International Agency for Research on Cancer (IARC) Cancer Review	Human Sufficient Evidence	IMEMDT 3,22,1973
International Agency for Research on Cancer (IARC) Cancer Review	Animal Sufficient Evidence	IMEMDT 3,22,1973
International Agency for Research on Cancer (IARC) Cancer Review	Group 1	IMSUDL 7,175,1987
TOXICOLOGY REVIEW		85CVA2 5,63,1970
TOXICOLOGY REVIEW		ZHPMAT 166,113,1978
TOXICOLOGY REVIEW		MUREAV 543,201,2003
TOXICOLOGY REVIEW		PAASAH 54,171,1959
TOXICOLOGY REVIEW		ENTOX* -,628,2005

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988	PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION	FEREAC 54,7740,1989
Occupational Exposure Limit - THE PHILIPPINES	time-weighted average 0.2 mg/m³, JAN1993
Occupational Exposure Limit - RUSSIA	short term exposure limit 5 mg/m³, Carcinogen, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO COAL TAR-air	Carcinogen; 10 hour time-weighted average 0.1 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X3773; Number of Industries 2; Total Number of Facilities 117; Number of Occupations 3; Total Number of Employees Exposed 852; Total Number of Female Employees Exposed 739

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121024/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen

REFERENCES:
CODEN	REFERENCE
26UYA8	"Psoriasis, Proceedings of the International Symposium, Stanford, CA, 1971," Farber, E.M., and A.J. Cox, eds., Stanford, CA, Stanford Univ. Press, 1971
85CVA2	"Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
85DKA8	"Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
ADMFAU	Archiv fuer Dermatologische Forschung. (Berlin, Ger.) V.240-252, 1971-75. For publisher information, see ADREDL.
AJCAA7	American Journal of Cancer. (New York, NY) V.15-40, 1931-40. For publisher information, see CNREA8.
AMIHBC	AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CRNGDP	Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC	Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT	IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL	IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JNCIAM	Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PAASAH	Publication of the American Association for the Advancement of Science. (Washington, DC) No.1-94, 1934-73. Discontinued.
SCPHA4	Scientia Pharmaceutica. (Oesterreichische Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria) V.1- 1930-
SWEHDO	Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
TOXID9	Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
ZHPMAT	Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung 1: Originale, Reihe B: Hygiene, Krankenhaushygiene, Betriebshygiene, Praeventive Medizin. (Stuttgart, Fed. Rep. Ger.) V.155-169, 1971-1979. For publisher information, see ZAOMDC.