RTECS:GF8281000 The Registry of Toxic Effects of Chemical Substances

Coal dust

RTECS #: GF8281000

CAS #: N/R

UPDATE: May 2009 MW: N/R MF: N/R

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

REFERENCES:

SYNONYMS:

Coal dust (ACGIH:OSHA)

Dust, coal

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 6,600 痢/m³/6 hour/86 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease AIHAAP 42,382,1981
inhalation
rat toxic concentration (other than lowest) : 14,900 痢/m³/6 hour/86 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Adrenal cortex tumors

Blood: Lymphoma including Hodgkin's disease AIHAAP 42,382,1981

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intratracheal
rat lowest published toxic dose: 9.26 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TOXID9 72,320,2003

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 68,337,1997
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 68,337,1997
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 68,337,1997
TOXICOLOGY REVIEW
MUREAV 566,21,2004

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2.4 mg/m³/%SiO2+2 (resp frct <5% SiO2) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 mg/m³/%SiO2+2 (>5% SiO2) CFRGBR 29,1910.1000,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 3 mg/m³ (respirable dust), JUL2008
Occupational Exposure Limit - DENMARK time-weighted average 2 mg/m³ (respirable), OCT 2002
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 1 mg/m³ (respirable), 4 mg/m³ (total), APR2007
Occupational Exposure Limit - KOREA time-weighted average 2 mg/m³, 2006
Occupational Exposure Limit - MEXICO time-weighted average 2 mg/m³, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 3 mg/m³ (respirable dust), JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.15 mg/m³ (respirable quartz), JAN2002
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

RTECS Compound Description:
Tumorigen

ALT CAS #: N/R
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 6,600 痢/m³/6 hour/86 week- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Lymphoma including Hodgkin's disease	AIHAAP 42,382,1981
inhalation rat	toxic concentration (other than lowest) : 14,900 痢/m³/6 hour/86 week- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Endocrine: Adrenal cortex tumors Blood: Lymphoma including Hodgkin's disease	AIHAAP 42,382,1981

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intratracheal rat	lowest published toxic dose: 9.26 mg/kg	Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOXID9 72,320,2003

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review	Human Inadequate Evidence	IMEMDT 68,337,1997
International Agency for Research on Cancer (IARC) Cancer Review	Animal Inadequate Evidence	IMEMDT 68,337,1997
International Agency for Research on Cancer (IARC) Cancer Review	Group 3	IMEMDT 68,337,1997
TOXICOLOGY REVIEW		MUREAV 566,21,2004

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8 hour time-weighted average 2.4 mg/m³/%SiO2+2 (resp frct <5% SiO2)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8 hour time-weighted average 10 mg/m³/%SiO2+2 (>5% SiO2)	CFRGBR 29,1910.1000,1994
Occupational Exposure Limit - AUSTRALIA	time-weighted average 3 mg/m³ (respirable dust), JUL2008
Occupational Exposure Limit - DENMARK	time-weighted average 2 mg/m³ (respirable), OCT 2002
Occupational Exposure Limit - JAPAN	Occupational Exposure Limit 1 mg/m³ (respirable), 4 mg/m³ (total), APR2007
Occupational Exposure Limit - KOREA	time-weighted average 2 mg/m³, 2006
Occupational Exposure Limit - MEXICO	time-weighted average 2 mg/m³, 2004
Occupational Exposure Limit - NEW ZEALAND	time-weighted average 3 mg/m³ (respirable dust), JAN2002
Occupational Exposure Limit - NEW ZEALAND	time-weighted average 0.15 mg/m³ (respirable quartz), JAN2002
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;
Occupational Exposure Limit IN SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
N/R	N/R	N/R

REFERENCES:
CODEN	REFERENCE
AIHAAP	American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR	Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
IMEMDT	IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOXID9	Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-