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Cinnamaldehyde

RTECS #: GD6475000

CAS #: 104-55-2

UPDATE: May 2009 MW: 132.17 MF: C9H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Propenal, 3 - phenyl - (9CI)
  2. 3 - Fenylpropenal (Czech)
  3. 3 - Phenylpropenal
  4. 3 - Phenyl - 2 - propenal
  5. 3 - Phenylacrolein
  6. 3 - Phenylacrylaldehyde
  7. Abion CA
  8. Acrolein, 3 - phenyl -
  9. Aldehyd skoricovy (Czech)
  1. Benzylideneacetaldehyde
  2. Cassia aldehyde
  3. Cinnamal
  4. Cinnamic aldehyde
  5. Cinnamyl aldehyde
  6. NCI - C56111
  7. Phenylacrolein
  8. Zimtaldehyde
  9. beta - Phenylcrolein


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		40 mg/48 hour severe FCTXAV 17,253,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 15 mg/L FCTOD7 22,623,1984
DNA damage human other cell types 7.5 mmol/L/4 hour MUREAV 577S,1,2005
DNA inhibition mouse leukocyte 31,500 µg/L DCTODJ 6,521,1983
DNA repair Bacillus subtilis 10,480 µg/disc OIGZDE 34,267,1985
mutation in microorganisms Salmonella typhimurium 500 µg/plate (-enzymatic activation step) FCTOD7 22,623,1984
morphological transform hamster embryo 50 µmol/L ENMUDM 8,515,1986
other mutation test systems mouse leukocyte 31,500 µg/L DCTODJ 6,521,1983
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster 		2 pph ENMUDM 7,677,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 55 mg/kg (7-17 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) FCTOD7 27,781,1989
oral
rat 		lowest published toxic dose: 275 mg/kg (7-17 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FCTOD7 27,781,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R FAONAU 44A,16,1967
intravenous
mouse 		lethal dose (50 percent kill): 75 mg/kg N/R CSLNX* NX#07571
oral
guinea pig 		lethal dose (50 percent kill): 1,160 mg/kg Behavioral: Coma FCTXAV 2,327,1964
oral
mouse 		lethal dose (50 percent kill): 2,225 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		YKKZAJ 92,135,1972
oral
rat 		lethal dose (50 percent kill): 2,220 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea 		FCTXAV 2,327,1964
parenteral
mouse 		lowest published lethal dose: 200 mg/kg N/R CBCCT* 7,687,1955


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 4,368 mg/kg/26 week- intermittent Lung, Thorax, or Respiration: Tumors

Tumorigenic: Protects against induction of experimental tumors 		CALEDQ 175,9,2002
oral
rat 		lowest published toxic dose: 35 mg/kg/24 week- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		BECTA6 49,306,1992
oral
rat 		lowest published toxic dose: 8,092 mg/kg/17 week- intermittent Liver: Liver function tests impaired VPITAR 33(5),48,1974
skin
human 		lowest published toxic concentration: 1 pph/48 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,177,2002
skin
mouse 		lowest published toxic dose: 750 mg/kg/3 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 45,89,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
DPIRDU 1(5),5,1981
TOXICOLOGY REVIEW
MUREAV 566,49,2004
TOXICOLOGY REVIEW
HUTOX* -,259,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83182;
Number of Industries 14;
Total Number of Facilities 372;
Number of Occupations 38;
Total Number of Employees Exposed 13,984
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83182;
Number of Industries 58;
Total Number of Facilities 6,159;
Number of Occupations 76;
Total Number of Employees Exposed 111,108;
Total Number of Female Employees Exposed 43,381


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the flavor and perfume industries
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HUTOX*
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975-
VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952-
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

Used in the flavor and perfume industries

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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