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Chymotrypsin

RTECS #: GC3050000

CAS #: 9004-07-3

UPDATE: January 1997 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. Alpha chymar
  2. Alpha - chymar ophth
  3. Avazyme
  4. Chymar
  5. Chymotest
  6. Chymotrypsin A
  7. Chymotrypsin B
  1. E.C. 3.4.4.5
  2. E.C. 3.4.4.6
  3. E.C. 3.4.21.1
  4. Enzeon
  5. Quimar
  6. Quimotrase
  7. alpha - Chymotrypsin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lethal dose (50 percent kill): 104 mg/kg N/R NIIRDN 6,202,1982
intramuscular
rat 		lethal dose (50 percent kill): 116 mg/kg N/R NIIRDN 6,202,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 65,100 µg/kg Skin: After systemic exposure: Dermatitis, other JAPMA8 39,42,1950
intravenous
guinea pig 		lowest published lethal dose: 50,000 units/kg Olfaction: Other olfaction effects

Cardiac: Other changes

Blood: Hemorrhage 		AIPTAK 106,164,1956
intravenous
mouse 		lethal dose (50 percent kill): 89 mg/kg N/R NIIRDN 6,202,1982
intravenous
rat 		lethal dose (50 percent kill): 84 mg/kg N/R NIIRDN 6,202,1982
intravenous
rabbit 		lethal dose (50 percent kill): 24,000 units/kg Gastrointestinal: Other changes

Blood: Hemorrhage

Skin: After systemic exposure: Dermatitis, other 		AIPTAK 106,164,1956
oral
mouse 		lethal dose (50 percent kill): >6 gm/kg N/R NIIRDN 6,202,1982
oral
rat 		lethal dose (50 percent kill): >4 gm/kg N/R NIIRDN 6,202,1982
subcutaneous
mouse 		lethal dose (50 percent kill): 185 mg/kg N/R NIIRDN 6,202,1982
subcutaneous
rat 		lethal dose (50 percent kill): 250 mg/kg N/R NIIRDN 6,202,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1606;
Number of Industries 1;
Total Number of Facilities 30;
Number of Occupations 4;
Total Number of Employees Exposed 992;
Total Number of Female Employees Exposed 931


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)

FDA-proprietary drug

RTECS Compound Description:
   Drug

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