The Registry of Toxic Effects of Chemical Substances

Chromic acid, disodium salt, tetrahydrate

RTECS #: GB2958300

CAS #: 10034-82-9

UPDATE: May 2008 MW: 303.03 MF: CrO4•2Na•4H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Sodium chromate tetrahydrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage hamster ovary 400 µmol/L MUREAV 299,95,1993
DNA damage human fibroblast 6 µmol/L/3 hour MUREAV 610,21,2006
mutation in microorganisms Salmonella typhimurium 33 µg/plate (+enzymatic activation step) ENMUDM 7,185,1985
morphological transform hamster embryo 500 µg/L CNREA8 39,1008,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		lethal dose (50 percent kill): 101 mg/kg Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Other changes

Skin: After systemic exposure: Dermatitis, other 		NTIS** OTS0535789


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(Cr)/m3 DTLVS* 3,35,1971
Occupational Exposure Limit - AUSTRIA TRK 0.05 mg(Cr)/m3, JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.1 mg(Cr)/m3 (production), JAN 2006
Occupational Exposure Limit - AUSTRIA TRK 0.1 mg(Cr)/m3 (welding fumes), JAN 2006
Occupational Exposure Limit - DENMARK time-weighted average 0.005 mg(Cr)/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 0.05 mg(Cr)/m3, FEB2006
Occupational Exposure Limit - SWEDEN time-weighted average 0.005 mg(Cr)/m3;
short term exposure limit 0.015 mg(Cr)/m3, Carcinogen, Sen, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7185;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 62


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay


REFERENCES:

CODEN
REFERENCE
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Mutagen

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