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Choline acetate (ester) , chloride

RTECS #: FZ9800000

CAS #: 60-31-1

UPDATE: May 2008 MW: 181.69 MF: C7H16NO2•Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. (2 - Hydroxyethyl) trimethylammonium chloride acetate
  2. 2 - (Acetyloxy) - N,N,N - trimethylethanaminium chloride
  3. 2 - Acetoxyethyltrimethylammonium chloride
  4. ACH chloride
  5. Acecholin
  6. Acecoline
  7. Acetylcholine chloride
  8. Acetylcholine hydrochloride
  9. Acetylcholinium chloride
  1. Ammonium, (2 - hydroxyethyl) trimethyl - , chloride, acetate
  2. Arterocoline
  3. Choline, chloride acetate
  4. Ethanaminium, 2 - (acetyloxy) - N,N,N - trimethyl - , chloride
  5. Miochol
  6. O - Acetylcholine chloride
  7. Ovisot
  8. TL 1505


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraarterial
dog 		lowest published toxic dose: 0.6 µg/kg Vascular: Measurement of regional blood flow EJPHAZ 543,68,2006
intraarterial
dog 		lowest published toxic dose: 100 ng/kg Vascular: Measurement of regional blood flow

Blood: Changes in spleen 		CEXPB9 33,81,2006
intracerebral
mouse 		lowest published lethal dose: 5,440 µg/kg Behavioral: Convulsions or effect on seizure threshold JPETAB 306,1159,2003
intraperitoneal
mouse 		lethal dose (50 percent kill): 15,300 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		FATOAO 20(4),32,1957
intravenous
guinea pig 		lethal dose (50 percent kill): 7,700 µg/kg N/R AIPTAK 170,461,1967
intravenous
mouse 		lethal dose (50 percent kill): 10 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change JPETAB 119,541,1957
intravenous
rat 		lethal dose (50 percent kill): 22 mg/kg N/R JPETAB 58,337,1936
intravenous
rat 		lowest published toxic dose: 1 µg/kg Vascular: BP lowering not characterized in autonomic section FCLPH* 20,57,2006
oral
mouse 		lethal dose (50 percent kill): 3 gm/kg N/R JPETAB 58,337,1936
oral
rat 		lethal dose (50 percent kill): 2,500 mg/kg N/R JPETAB 58,337,1936
parenteral
frog 		lowest published lethal dose: 200 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Stiffness

Cardiac: Other changes 		AEPPAE 166,437,1932
subcutaneous
mouse 		lethal dose (50 percent kill): 170 mg/kg N/R JPETAB 58,337,1936
subcutaneous
rat 		lethal dose (50 percent kill): 250 mg/kg N/R JPETAB 58,337,1936
unreported route
frog 		lowest published lethal dose: 500 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Altered sleep time (including change in righting reflex) 		AEPPAE 164,346,1932


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3203;
Number of Industries 2;
Total Number of Facilities 121;
Number of Occupations 5;
Total Number of Employees Exposed 2,698;
Total Number of Female Employees Exposed 1,846


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

Used as a cholinergic agent

FDA-proprietary drug

RTECS Compound Description:
   Drug

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