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Cholic acid, sodium salt

RTECS #: FZ9600000

CAS #: 361-09-1

UPDATE: December 2000 MW: 430.62 MF: C24H39O5•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Cholan - 24 - oic acid, 3,7,12 - trihydroxy - , monosodium salt, (3 - alpha,5 - beta,7 - alpha,12 - alpha) -
  2. Cholic acid, monosodium salt
  3. DS - Na
  1. Sodium cholate
  2. Sodium cholic acid
  3. Trihydroxy 3 - 7 - 12 cholanate de Na (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 164 mg/kg Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Hypermotility, diarrhea 		ESKHA5 (103),29,1985
intravenous
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R AIPTAK 90,18,1952
intravenous
rabbit 		lowest published lethal dose: 50 mg/kg Behavioral: Convulsions or effect on seizure threshold ZGEMAZ 52,779,1926
oral
mouse 		lethal dose (50 percent kill): 2,400 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Ulceration or bleeding from small intestine 		ESKHA5 (103),29,1985
oral
rat 		lowest published lethal dose: 713 mg/kg Behavioral: Coma

Cardiac: EKG changes not diagnostic of above

Vascular: BP lowering not characterized in autonomic section 		JFASEO 91,743,1992


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 126 gm/kg/21 day- continuous Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		PSEBAA 120,48,1965


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1798;
Number of Industries 1;
Total Number of Facilities 82;
Number of Occupations 2;
Total Number of Employees Exposed 82
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1798;
Number of Industries 2;
Total Number of Facilities 585;
Number of Occupations 6;
Total Number of Employees Exposed 6,463;
Total Number of Female Employees Exposed 4,599


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
JFASEO Journal of the Formosan Medical Association. (Excerpta Medica Asia Ltd., 3/F, 13 Duddell St. Central, Hong Kong, Hong Kong) V. 90- 1991-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin, Fed. Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS.

RTECS Compound Description:
   Drug

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