RTECS:FK9625000 The Registry of Toxic Effects of Chemical Substances

Cesium chloride

RTECS #: FK9625000

CAS #: 7647-17-8

UPDATE: August 2006 MW: 168.36 MF: ClCs

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Cesium monochloride

Dicesium dichloride

Tricesium trichloride

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis oral
mouse 125 mg/kg MUREAV 244,295,1990
DNA damage oral
mouse 1,680 mg/kg/120 day MUREAV 577S,1,2005
DNA repair Bacillus subtilis 5 mole/L MUREAV 77,109,1980
micronucleus test oral
mouse 1,000 mg/kg MUREAV 497,147,2001
micronucleus test intraperitoneal
mouse 500 mg/kg MUREAV 497,147,2001
other mutation test systems oral
mouse 500 mg/kg MUREAV 244,295,1990
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 20 mmol/L MUTAEX 1,21,1986

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
mouse lowest published toxic dose: 262 gm/kg (1-21 day pregnant/21 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical PHBHA4 46,89,1989
oral
rat lowest published toxic dose: 706 mg/kg (1-21 day prior to copulation/21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical GEPHDP 25,395,1994

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 1,460 mg/kg N/R COREAF 256,1043,1963
intraperitoneal
mouse lowest published lethal dose: 1,329 mg(Cs)/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands PBBHAU 21,17,1984
intraperitoneal
mouse lowest published toxic dose: 359 mg(Cs)/kg Behavioral: Change in motor activity (specific assay) PBBHAU 21,17,1984
intraperitoneal
rat lethal dose (50 percent kill): 1,316 mg/kg N/R VCVN1* -,58,1998
intravenous
cat lethal dose (50 percent kill): 640 mg/kg Behavioral: Excitement

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression VCVN1* -,58,1998
intravenous
mouse lethal dose (50 percent kill): 910 mg/kg N/R NYKZAU 56(4),118S,1960
intravenous
rat lethal dose (50 percent kill): 1,075 mg/kg Behavioral: Convulsions or effect on seizure threshold

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Proteinuria STGNBT -,244,1999
intravenous
rat lethal dose (50 percent kill): 1,075 mg/kg Behavioral: Excitement

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression VCVN1* -,58,1998
intravenous
rabbit lowest published lethal dose: 1 gm/kg N/R NYKZAU 56(4),118S,1960
intravenous
rabbit lethal dose (50 percent kill): 200 mg(Cs)/kg N/R VCVN1* -,255,1988
oral
mouse lethal dose (50 percent kill): 2,306 mg/kg N/R VAMNAQ (8),10,1978
oral
rat lethal dose (50 percent kill): 2,004 mg/kg N/R VCVN1* -,58,1998
subcutaneous
mouse lethal dose (50 percent kill): 2,750 mg/kg Behavioral: Convulsions or effect on seizure threshold

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Proteinuria STGNBT -,244,1999
subcutaneous
mouse lethal dose (50 percent kill): 2,750 mg/kg N/R VCVN1* -,58,1998
subcutaneous
rat lethal dose (50 percent kill): 2,590 mg/kg Behavioral: Convulsions or effect on seizure threshold

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Proteinuria STGNBT -,244,1999
subcutaneous
rat lethal dose (50 percent kill): 2,590 mg/kg N/R VCVN1* -,58,1998

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published toxic dose: 4,652 mg(Cs)/kg/7 day- intermittent Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Alteration of classical conditioning PBBHAU 21,17,1984
intraperitoneal
mouse lowest published toxic dose: 2,791 mg(Cs)/kg/42 day- intermittent Tumorigenic: Protects against induction of experimental tumors PBBHAU 21,17,1984
intraperitoneal
mouse lowest published toxic dose: 3,456 mg(Cs)/kg/52 day- intermittent Tumorigenic: Protects against induction of experimental tumors PBBHAU 21,17,1984
intraperitoneal
rat lowest published toxic dose: 1,595 mg(Cs)/kg/4 day- intermittent Behavioral: Alteration of classical conditioning PBBHAU 21,17,1984
oral
man lowest published toxic dose: 3.1 gm/kg/36 day- intermittent Peripheral Nerve and Sensation: Paresthesia

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting PBBHAU 21,15,1984

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3874;
Number of Industries 3;
Total Number of Facilities 189;
Number of Occupations 6;
Total Number of Employees Exposed 3,353;
Total Number of Female Employees Exposed 1,792

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973-
PHBHA4 Physiology and Behavior. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1966-
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
VAMNAQ Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy of Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1946-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used in final evacuation of radio and television vacuum tubes, in X-ray fluoroescent screens

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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SYNONYMS:
Cesium monochloride Dicesium dichloride	Tricesium trichloride

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	oral mouse	125 mg/kg	MUREAV 244,295,1990
DNA damage	oral mouse	1,680 mg/kg/120 day	MUREAV 577S,1,2005
DNA repair	Bacillus subtilis	5 mole/L	MUREAV 77,109,1980
micronucleus test	oral mouse	1,000 mg/kg	MUREAV 497,147,2001
micronucleus test	intraperitoneal mouse	500 mg/kg	MUREAV 497,147,2001
other mutation test systems	oral mouse	500 mg/kg	MUREAV 244,295,1990
sex chromosome loss and nondisjunction	Saccharomyes cerevisiae	20 mmol/L	MUTAEX 1,21,1986

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral mouse	lowest published toxic dose: 262 gm/kg (1-21 day pregnant/21 day after birth)	Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Physical	PHBHA4 46,89,1989
oral rat	lowest published toxic dose: 706 mg/kg (1-21 day prior to copulation/21 day after birth)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Physical	GEPHDP 25,395,1994

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 1,460 mg/kg	N/R	COREAF 256,1043,1963
intraperitoneal mouse	lowest published lethal dose: 1,329 mg(Cs)/kg	Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands	PBBHAU 21,17,1984
intraperitoneal mouse	lowest published toxic dose: 359 mg(Cs)/kg	Behavioral: Change in motor activity (specific assay)	PBBHAU 21,17,1984
intraperitoneal rat	lethal dose (50 percent kill): 1,316 mg/kg	N/R	VCVN1* -,58,1998
intravenous cat	lethal dose (50 percent kill): 640 mg/kg	Behavioral: Excitement Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory depression	VCVN1* -,58,1998
intravenous mouse	lethal dose (50 percent kill): 910 mg/kg	N/R	NYKZAU 56(4),118S,1960
intravenous rat	lethal dose (50 percent kill): 1,075 mg/kg	Behavioral: Convulsions or effect on seizure threshold Vascular: BP elevation not characterized in autonomic section Kidney, Ureter, and Bladder: Proteinuria	STGNBT -,244,1999
intravenous rat	lethal dose (50 percent kill): 1,075 mg/kg	Behavioral: Excitement Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory depression	VCVN1* -,58,1998
intravenous rabbit	lowest published lethal dose: 1 gm/kg	N/R	NYKZAU 56(4),118S,1960
intravenous rabbit	lethal dose (50 percent kill): 200 mg(Cs)/kg	N/R	VCVN1* -,255,1988
oral mouse	lethal dose (50 percent kill): 2,306 mg/kg	N/R	VAMNAQ (8),10,1978
oral rat	lethal dose (50 percent kill): 2,004 mg/kg	N/R	VCVN1* -,58,1998
subcutaneous mouse	lethal dose (50 percent kill): 2,750 mg/kg	Behavioral: Convulsions or effect on seizure threshold Vascular: BP elevation not characterized in autonomic section Kidney, Ureter, and Bladder: Proteinuria	STGNBT -,244,1999
subcutaneous mouse	lethal dose (50 percent kill): 2,750 mg/kg	N/R	VCVN1* -,58,1998
subcutaneous rat	lethal dose (50 percent kill): 2,590 mg/kg	Behavioral: Convulsions or effect on seizure threshold Vascular: BP elevation not characterized in autonomic section Kidney, Ureter, and Bladder: Proteinuria	STGNBT -,244,1999
subcutaneous rat	lethal dose (50 percent kill): 2,590 mg/kg	N/R	VCVN1* -,58,1998

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lowest published toxic dose: 4,652 mg(Cs)/kg/7 day- intermittent	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Alteration of classical conditioning	PBBHAU 21,17,1984
intraperitoneal mouse	lowest published toxic dose: 2,791 mg(Cs)/kg/42 day- intermittent	Tumorigenic: Protects against induction of experimental tumors	PBBHAU 21,17,1984
intraperitoneal mouse	lowest published toxic dose: 3,456 mg(Cs)/kg/52 day- intermittent	Tumorigenic: Protects against induction of experimental tumors	PBBHAU 21,17,1984
intraperitoneal rat	lowest published toxic dose: 1,595 mg(Cs)/kg/4 day- intermittent	Behavioral: Alteration of classical conditioning	PBBHAU 21,17,1984
oral man	lowest published toxic dose: 3.1 gm/kg/36 day- intermittent	Peripheral Nerve and Sensation: Paresthesia Gastrointestinal: Hypermotility, diarrhea Gastrointestinal: Nausea or vomiting	PBBHAU 21,15,1984

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X3874; Number of Industries 3; Total Number of Facilities 189; Number of Occupations 6; Total Number of Employees Exposed 3,353; Total Number of Female Employees Exposed 1,792

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN	REFERENCE
COREAF	Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
GEPHDP	General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX	Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NYKZAU	Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PBBHAU	Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973-
PHBHA4	Physiology and Behavior. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1966-
STGNBT	"Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
VAMNAQ	Vestnik Akademii Meditsinskikh Nauk SSSR. Journal of the Academy of Medical Sciences of the USSR. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1946-
VCVN1*	"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.