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| UPDATE: February 2009 | MW: 100.09 | MF: CO3•Ca |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
eye | rabbit
750 µg/24 hour
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severe
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28ZPAK -,267,1972
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skin | rabbit
500 mg/24 hour
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moderate
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28ZPAK -,267,1972
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
N/R
|
N/R
|
N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
oral | rat
lethal dose (50 percent kill): 6,450 mg/kg
|
N/R
|
28ZPAK -,267,1972
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oral | rat
lowest published toxic dose: 60 gm/kg
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Gastrointestinal: Hypermotility, diarrhea | Gastrointestinal: Other changes
EPASR* #86940001000,1994
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oral | rat
lowest published toxic dose: 10 mg/kg
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Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
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INJPD2 38,397,2006
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
oral | woman
lowest published toxic dose: 4.08 gm/kg/30 day- intermittent
|
Vascular: BP elevation not characterized in autonomic section | Gastrointestinal: Changes in structure or function of exocrine pancreas Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
MJAUAJ 182,350,2005
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REVIEWS:
ORGANIZATION
|
STANDARD
|
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
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REFERENCE
Occupational Exposure Limit - BELGIUM
|
time-weighted average 0.01 mg(Ag)/m3, MAR2002
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Occupational Exposure Limit - FRANCE
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VME 10 mg/m3, FEB2006
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Occupational Exposure Limit - JAPAN
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Occupational Exposure Limit 0.01 mg(Ag)/m3, APR2007
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 10 mg/m3, 2003
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
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REFERENCE
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: M0841; | Number of Industries 17; Total Number of Facilities 1,433; Number of Occupations 12; Total Number of Employees Exposed 18,263
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 15705; | Number of Industries 338; Total Number of Facilities 80,902; Number of Occupations 189; Total Number of Employees Exposed 1,002,651
National Occupational Exposure Survey 1983
|
National Occupational Exposure Survey 1983: Hazard Code: X6785 | Number of Industries 7; Total Number of Facilities 1,255; Number of Occupations 16; Total Number of Employees Exposed 20,008; Total Number of Female Employees Exposed 656
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: X9060 | Number of Industries 4; Total Number of Facilities 292; Number of Occupations 4; Total Number of Employees Exposed 6,239; Total Number of Female Employees Exposed 2,955
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 15705 |
Number of Industries 392; Total Number of Facilities 131,230; Number of Occupations 237; Total Number of Employees Exposed 2,341,639; Total Number of Female Employees Exposed 392,183 | |||||||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NIOSH Analytical Method, 1994: Calcium and compounds, 7020
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REFERENCES:
CODEN
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REFERENCE
28ZPAK
|
"Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro
Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
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EPASR*
|
United States Environmental Protection Agency, Office of Pesticides and Toxic Substances.
(U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
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INJPD2
|
Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221
005, India) V.1- 1968(?)-
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MJAUAJ
|
Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe,
N.S.W., Australia) V.1- 1914-
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