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Carbamic acid, ethylenebis (dithio - , disodium salt

RTECS #: FA6825000

CAS #: 142-59-6

UPDATE: May 2009 MW: 256.34 MF: C4H6N2S4•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,2 - Ethanediylbiscarbamodithioic acid disodium salt
  2. Carbamodithioic acid, 1,2 - ethanediylbis - , disodium salt (9CI)
  3. Chem BAM
  4. DSE
  5. Di - natrium - aethylenbisdithiocarbamat (German)
  6. Dinatrium - (N,N' - aethylen - bis (dithiocarbamat) ) (German)
  7. Dinatrium - (N,N' - ethyleen - bis (dithiocarbamaat) ) (Dutch)
  8. Disodium ethylenebis (dithiocarbamate)
  9. Disodium ethylene - 1,2 - bisdithiocarbamate
  10. Dithane A - 40
  11. Dithane D - 14
  12. Ethylen - bis - dithiokarbaman sodny (Czech)
  1. Ethylenebis (dithiocarbamate) , disodium salt
  2. Ethylenebis (dithiocarbamic acid) disodium salt
  3. N,N' - Ethylene bis (dithiocarbamate de sodium) (French)
  4. N,N' - Etilen - bis (ditiocarbammato) di sodio (Italian)
  5. Nabam
  6. Nabame (French)
  7. Nabasan
  8. Nafun IPO
  9. Parzate
  10. Parzate liquid
  11. Spring - bak


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms other microorganisms 1,000 ppm (-enzymatic activation step) MMAPAP 50,233,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 194 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** PB223-160
subcutaneous
mouse 		lowest published toxic dose: 418 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 500 mg/kg N/R 85DPAN -,-,1971/1976
oral
mouse 		lethal dose (50 percent kill): 580 mg/kg N/R PCOC** -,777,1966
oral
rat 		lethal dose (50 percent kill): 395 mg/kg N/R FEPRA7 11,391,1952


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 4,725 mg/kg/7 day- intermittent Endocrine: Changes in spleen weight JTEHD6 37,559,1992
oral
rat 		lowest published toxic dose: 235 mg/kg/28 day- continuous Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		ATSUDG 9,339,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
HUTOX* -,561,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,135,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84470;
Number of Industries 4;
Total Number of Facilities 111;
Number of Occupations 6;
Total Number of Employees Exposed 798
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84470;
Number of Industries 14;
Total Number of Facilities 500;
Number of Occupations 11;
Total Number of Employees Exposed 7,277;
Total Number of Female Employees Exposed 33


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as raw material for pesticide manufacture
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HUTOX*
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MMAPAP Mycopathologia et Mycologia Applicata. (The Hague, Netherlands) V.5-54(4), 1950-74. For publisher information, see MYCPAH.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as raw material for pesticide manufacture

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

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