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Camphene

RTECS #: EX1055000

CAS #: 79-92-5

UPDATE: July 2002 MW: 136.26 MF: C10H16


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 3,3 - Dimethyl - 2 - methylenenorcamphene
  1. Bicyclo (2.2.1) heptane, 2,2 - dimethyl - 3 - methylene - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium 		2,500 mg/kg NUCADQ 1,10,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 17,100 mg/m3/4 hour Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea 		VCVPS* -,298,1998
inhalation
rat 		lethal concentration (50 percent kill): 17,100 mg/m3/5 minute Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Behavioral: Alteration of classical conditioning 		VCVPS* -,298,1998
inhalation
rat 		lethal concentration (50 percent kill): 17,100 mg/m3/1 hour Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia

Behavioral: Irritability 		VCVPS* -,298,1998
intraperitoneal
mouse 		lethal dose : >500 mg/kg N/R CBCCT* 4,376,1952
oral
rat 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 13,735,1975
skin
rabbit 		lethal dose (50 percent kill): >2,500 mg/kg N/R FCTXAV 13,735,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 3.6 mg/m3/24 hour/90 day- continuous Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Respiratory stimulation

Lung, Thorax, or Respiration: Other changes 		VCVPS* -,298,1998
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 32.2 mg/m3/24 hour/90 day- continuous Liver: Fatty liver degeneration

Liver: Other changes

Blood: Hemorrhage 		VCVPS* -,298,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4188;
Number of Industries 1;
Total Number of Facilities 25;
Number of Occupations 4;
Total Number of Employees Exposed 2,675
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4188;
Number of Industries 81;
Total Number of Facilities 6,181;
Number of Occupations 83;
Total Number of Employees Exposed 114,605;
Total Number of Female Employees Exposed 29,452


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
NUCADQ Nutrition and Cancer. (Franklin Institute Press, POB 2266, Phildelphia, PA 19103) V.1- 1978-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.

RTECS Compound Description:
   Mutagen
   Natural Product

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