RTECS:EL3854000 The Registry of Toxic Effects of Chemical Substances

1 - Butanol, 2,2' - (ethylenediimino) di - , dihydrochloride, (+) -

RTECS #: EL3854000

CAS #: 1070-11-7

UPDATE: August 2004 MW: 277.28 MF: C₁₀H₂₄N₂O₂•2ClH

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

1 - Butanol, 2,2' - (1,2 - ethanediyldiimino) bis - , dihydrochloride, (R - (R,R) ) - (9CI)

CL 40881

Dadibutol

Ethambutol dihydrochloride

Ethambutol hydrochloride

Myambutol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
micronucleus test oral
mouse 50 mg/kg IRLCDZ 10,135,1982
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 4,400 mg/L IMSCE2 14,745,1986
sperm morphology oral
mouse 12,500 µg/kg IRLCDZ 10,135,1982

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 1 gm/kg Peripheral Nerve and Sensation: Local anesthetic

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold YAKUD5 9,724,1967
intraperitoneal
rat lethal dose (50 percent kill): 1,200 mg/kg N/R OYYAA2 2,70,1968
intravenous
mouse lethal dose (50 percent kill): 230 mg/kg N/R OYYAA2 2,70,1968
intravenous
rat lethal dose (50 percent kill): 300 mg/kg N/R OYYAA2 2,70,1968
oral
man lowest published toxic dose: 45 mg/kg/3 day- intermittent Eye: Visual field changes

Eye: Other eye effects BJDCAT 80,288,1986
oral
man lowest published toxic dose: 46 mg/kg/3 day- intermittent Eye: Visual field changes PGMJAO 61,811,1985
oral
mouse lethal dose (50 percent kill): 8,900 mg/kg N/R OYYAA2 2,70,1968
oral
rat lethal dose (50 percent kill): 6,800 mg/kg N/R OYYAA2 2,70,1968
subcutaneous
mouse lethal dose (50 percent kill): 1,800 mg/kg N/R OYYAA2 2,70,1968
unreported route
woman lowest published toxic dose: 720 mg/kg/48 day Eye: Visual field changes ANOPB5 2,578,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
dog lowest published toxic dose: 31,200 mg/kg/22 week- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Cardiac: Other changes

Liver: Other changes TXAPA9 7,844,1965
subcutaneous
rat lowest published toxic dose: 14 gm/kg/4 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Eye: Other eye effects TXAPA9 189,134,2003

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5347;
Number of Industries 1;
Total Number of Facilities 93;
Number of Occupations 2;
Total Number of Employees Exposed 590;
Total Number of Female Employees Exposed 430

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

ANOPB5 Annals of Ophthalmology. (American Soc. of Contemporary Ophthalmology, POB 64025, Baltimore, MD 21264) V.1- 1969-
BJDCAT British Journal of Diseases of the Chest. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.53- 1959-
IMSCE2 IRCS Medical Science. (Lancaster, UK) V.12-14, 1984-86. For publisher information, see MSCREJ.
IRLCDZ IRCS Medical Science: Library Compendium. (Lancaster, UK) V.3-11, 1975-83. For publisher information, see IMSCE2.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

RTECS Compound Description:
   Drug
   Mutagen
   Human Data

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SYNONYMS:
1 - Butanol, 2,2' - (1,2 - ethanediyldiimino) bis - , dihydrochloride, (R - (R,R) ) - (9CI) CL 40881 Dadibutol	Ethambutol dihydrochloride Ethambutol hydrochloride Myambutol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
micronucleus test	oral mouse	50 mg/kg	IRLCDZ 10,135,1982
sex chromosome loss and nondisjunction	oral Drosophila melanogaster	4,400 mg/L	IMSCE2 14,745,1986
sperm morphology	oral mouse	12,500 µg/kg	IRLCDZ 10,135,1982

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 1 gm/kg	Peripheral Nerve and Sensation: Local anesthetic Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold	YAKUD5 9,724,1967
intraperitoneal rat	lethal dose (50 percent kill): 1,200 mg/kg	N/R	OYYAA2 2,70,1968
intravenous mouse	lethal dose (50 percent kill): 230 mg/kg	N/R	OYYAA2 2,70,1968
intravenous rat	lethal dose (50 percent kill): 300 mg/kg	N/R	OYYAA2 2,70,1968
oral man	lowest published toxic dose: 45 mg/kg/3 day- intermittent	Eye: Visual field changes Eye: Other eye effects	BJDCAT 80,288,1986
oral man	lowest published toxic dose: 46 mg/kg/3 day- intermittent	Eye: Visual field changes	PGMJAO 61,811,1985
oral mouse	lethal dose (50 percent kill): 8,900 mg/kg	N/R	OYYAA2 2,70,1968
oral rat	lethal dose (50 percent kill): 6,800 mg/kg	N/R	OYYAA2 2,70,1968
subcutaneous mouse	lethal dose (50 percent kill): 1,800 mg/kg	N/R	OYYAA2 2,70,1968
unreported route woman	lowest published toxic dose: 720 mg/kg/48 day	Eye: Visual field changes	ANOPB5 2,578,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral dog	lowest published toxic dose: 31,200 mg/kg/22 week- continuous	Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Cardiac: Other changes Liver: Other changes	TXAPA9 7,844,1965
subcutaneous rat	lowest published toxic dose: 14 gm/kg/4 week- intermittent	Brain and Coverings: Recordings from specific areas of CNS Eye: Other eye effects	TXAPA9 189,134,2003

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X5347; Number of Industries 1; Total Number of Facilities 93; Number of Occupations 2; Total Number of Employees Exposed 590; Total Number of Female Employees Exposed 430

REFERENCES:
CODEN	REFERENCE
ANOPB5	Annals of Ophthalmology. (American Soc. of Contemporary Ophthalmology, POB 64025, Baltimore, MD 21264) V.1- 1969-
BJDCAT	British Journal of Diseases of the Chest. (Bailliere Tindall, 33 The Avenue, Eastbourne BN21 3UN, UK) V.53- 1959-
IMSCE2	IRCS Medical Science. (Lancaster, UK) V.12-14, 1984-86. For publisher information, see MSCREJ.
IRLCDZ	IRCS Medical Science: Library Compendium. (Lancaster, UK) V.3-11, 1975-83. For publisher information, see IMSCE2.
OYYAA2	Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PGMJAO	Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YAKUD5	Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-