RTECS:EK5425000 The Registry of Toxic Effects of Chemical Substances

Butane, 1,1' - oxybis -

RTECS #: EK5425000

CAS #: 142-96-1

UPDATE: August 2007 MW: 130.26 MF: C₈H₁₈O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

1,1' - Oxybis (butane)

1 - Butoxybutane

Butyl ether

Di - n - butyl ether

Dibutyl ether

Dibutyl oxide

Ether butylique (French)

n - Butyl ether

n - Dibutyl ether

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
human 200 ppm/15 minute N/R JIHTAB 28,262,1946
skin
rabbit 380 mg open irritation test mild UCDS 7/8/1971

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE**
inhalation
human lowest published toxic concentration: 200 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation JIHTAB 28,262,1946
inhalation
human lowest published toxic concentration: 1,000 mg/m³/3 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough VCVGK* -,269,1994
inhalation
mouse lethal concentration (50 percent kill): 169 gm/m³/15 minute Behavioral: General anesthetic ANESAV 11,455,1950
inhalation
mouse lowest published lethal concentration: 60,000 mg/m³/2 hour Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration VCVGK* -,269,1994
inhalation
mouse lowest published toxic concentration: 10,000 mg/m³/30 minute Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration VCVGK* -,269,1994
inhalation
mouse lowest published toxic concentration: 10,000 mg/m³/75 minute Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration VCVGK* -,269,1994
inhalation
rat lowest published lethal concentration: 4,000 ppm/4 hour N/R AMIHBC 10,61,1954
inhalation
rat lowest published lethal concentration: 20,200 mg/m³/4 hour Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration VCVGK* -,269,1994
inhalation
rat lethal concentration (50 percent kill): 4,000 ppm/4 hour N/R ENTOX* -,358,2005
intravenous
mouse lowest published lethal dose: 258 mg/kg Behavioral: Altered sleep time (including change in righting reflex) APTOA6 37,56,1975
oral
mouse lethal dose (50 percent kill): 567 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration VCVGK* -,269,1994
oral
mouse lowest published toxic dose: 455 mg/kg Behavioral: Irritability

Liver: Fatty liver degeneration VCVGK* -,269,1994
oral
rat lethal dose (50 percent kill): 3,200 mg/kg N/R ENTOX* -,358,2005
skin
rabbit lethal dose (50 percent kill): 10 mL/kg N/R VCVGK* -,269,1994
skin
rabbit lethal dose (50 percent kill): 10,000 mg/kg N/R ENTOX* -,358,2005

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 0.4 gm/kg/4 week- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins TXCYAC 214,99,2005
oral
rat lowest published toxic dose: 4 gm/kg/4 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins TXCYAC 214,99,2005

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ENTOX* -,358,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 20 mg/m³, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84736;
Number of Industries 3;
Total Number of Facilities 97;
Number of Occupations 5;
Total Number of Employees Exposed 1,004
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84736;
Number of Industries 4;
Total Number of Facilities 468;
Number of Occupations 18;
Total Number of Employees Exposed 6,292;
Total Number of Female Employees Exposed 235

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
Human Data
Primary Irritant

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SYNONYMS:
1,1' - Oxybis (butane) 1 - Butoxybutane Butyl ether Di - n - butyl ether Dibutyl ether	Dibutyl oxide Ether butylique (French) n - Butyl ether n - Dibutyl ether

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye human	200 ppm/15 minute	N/R	JIHTAB 28,262,1946
skin rabbit	380 mg open irritation test	mild	UCDS** 7/8/1971

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation human	lowest published toxic concentration: 200 ppm	Olfaction: Other olfaction effects Eye: Conjunctiva irritation	JIHTAB 28,262,1946
inhalation human	lowest published toxic concentration: 1,000 mg/m³/3 minute	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,269,1994
inhalation mouse	lethal concentration (50 percent kill): 169 gm/m³/15 minute	Behavioral: General anesthetic	ANESAV 11,455,1950
inhalation mouse	lowest published lethal concentration: 60,000 mg/m³/2 hour	Lung, Thorax, or Respiration: Other changes Liver: Fatty liver degeneration	VCVGK* -,269,1994
inhalation mouse	lowest published toxic concentration: 10,000 mg/m³/30 minute	Behavioral: Ataxia Lung, Thorax, or Respiration: Other changes Liver: Fatty liver degeneration	VCVGK* -,269,1994
inhalation mouse	lowest published toxic concentration: 10,000 mg/m³/75 minute	Behavioral: General anesthetic Lung, Thorax, or Respiration: Other changes Liver: Fatty liver degeneration	VCVGK* -,269,1994
inhalation rat	lowest published lethal concentration: 4,000 ppm/4 hour	N/R	AMIHBC 10,61,1954
inhalation rat	lowest published lethal concentration: 20,200 mg/m³/4 hour	Lung, Thorax, or Respiration: Other changes Liver: Fatty liver degeneration	VCVGK* -,269,1994
inhalation rat	lethal concentration (50 percent kill): 4,000 ppm/4 hour	N/R	ENTOX* -,358,2005
intravenous mouse	lowest published lethal dose: 258 mg/kg	Behavioral: Altered sleep time (including change in righting reflex)	APTOA6 37,56,1975
oral mouse	lethal dose (50 percent kill): 567 mg/kg	Lung, Thorax, or Respiration: Other changes Liver: Fatty liver degeneration	VCVGK* -,269,1994
oral mouse	lowest published toxic dose: 455 mg/kg	Behavioral: Irritability Liver: Fatty liver degeneration	VCVGK* -,269,1994
oral rat	lethal dose (50 percent kill): 3,200 mg/kg	N/R	ENTOX* -,358,2005
skin rabbit	lethal dose (50 percent kill): 10 mL/kg	N/R	VCVGK* -,269,1994
skin rabbit	lethal dose (50 percent kill): 10,000 mg/kg	N/R	ENTOX* -,358,2005

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 0.4 gm/kg/4 week- intermittent	Liver: Other changes Biochemical: Metabolism (intermediary): Other proteins	TXCYAC 214,99,2005
oral rat	lowest published toxic dose: 4 gm/kg/4 week- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other proteins	TXCYAC 214,99,2005

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		ENTOX* -,358,2005

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - RUSSIA	short term exposure limit 20 mg/m³, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 84736; Number of Industries 3; Total Number of Facilities 97; Number of Occupations 5; Total Number of Employees Exposed 1,004
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 84736; Number of Industries 4; Total Number of Facilities 468; Number of Occupations 18; Total Number of Employees Exposed 6,292; Total Number of Female Employees Exposed 235

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
AMIHBC	AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ANESAV	Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
APTOA6	Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
JIHTAB	Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
TXCYAC	Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS**	Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.