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Butanedioic acid, mono (3,4 - dihydro - 2,5,7,8 - tetramethyl - 2 - (4,8,12 - trimethyltridecyl) - 2H - 1 - benzopyran - 6 - yl) ester, (2R - (2R* (4R*,8R*) ) ) -

RTECS #: EJ9984000

CAS #: 4345-03-3

UPDATE: May 2009 MW: 530.87 MF: C33H54O5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. (+) - alpha - Tocopheryl succinate
  2. D - alpha - Tocopheryl succinate
  3. Succinic acid, mono (2,5,7,8 - tetramethyl - 2 - (4,8,12 - trimethyltridecyl) - 6 - chromanyl) ester, (+) -
  4. Vitamin E succinate
  5. alpha - Tocopherol hemisuccinate
  1. alpha - Tocopherol, succinate (6CI)
  2. alpha - Tocopheryl acid succinate
  3. alpha - Tocopheryl succinate
  4. d - alpha - Tocopherol acid succinate
  5. d - alpha - Tocopheryl acid succinate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 117 mg/kg Behavioral: Ataxia FCTOD7 46,508,2008
oral
rat 		lethal dose (50 percent kill): >7 gm/kg N/R IJTOFN 21,51,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 1,053 mg/kg/27 day- intermittent Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response 		FCTOD7 46,508,2008
intraperitoneal
mouse 		lowest published toxic dose: 480 mg/kg/8 day- intermittent Tumorigenic: Active as anti-cancer agent CNREA8 66,9374,2006
oral
rat 		lowest published toxic dose: 4.2 gm/kg/42 day- continuous Tumorigenic: Protects against induction of experimental tumors TOXID9 72,213,2003
oral
rat 		lowest published toxic dose: 3,600 mg/kg/90 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		JTEHF8 69,381,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
IJTOFN 21,51,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1129;
Number of Industries 1;
Total Number of Facilities 19;
Number of Occupations 9;
Total Number of Employees Exposed 934;
Total Number of Female Employees Exposed 506


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

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