RTECS:ED7350000 The Registry of Toxic Effects of Chemical Substances

Boron

RTECS #: ED7350000

CAS #: 7440-42-8

UPDATE: August 2007 MW: 10.81 MF: B

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:
N/R N/R

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 4.95 mg/kg (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death VCVN1* -,195,1988

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 11 gm/kg N/R GTPZAB 35(2),42,1991
intraperitoneal
rat lethal dose (50 percent kill): 7 gm/kg N/R GTPZAB 35(2),42,1991
oral
cat lethal dose (50 percent kill): 250 mg/kg N/R GISAAA 35(11),11,1970
oral
dog lethal dose (50 percent kill): 310 mg/kg N/R GISAAA 35(11),11,1970
oral
guinea pig lethal dose (50 percent kill): 310 mg/kg N/R GISAAA 35(11),11,1970
oral
mammal (species unspecified) lethal dose (50 percent kill): 300 mg/kg N/R GISAAA 40(9),49,1975
oral
mouse lethal dose (50 percent kill): 560 mg/kg N/R GISAAA 35(11),11,1970
oral
rat lethal dose (50 percent kill): 650 mg/kg N/R GISAAA 35(11),11,1970
oral
rabbit lethal dose (50 percent kill): 310 mg/kg N/R GISAAA 35(11),11,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 10,560 痢/m³/4 hour/17 week- intermittent Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain GTPZAB 35(2),42,1991
oral
rat lowest published toxic dose: 32 gm/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Other changes

Liver: Liver function tests impaired GTPZAB 35(2),42,1991
oral
rabbit lowest published toxic dose: 2,821 mg/kg/13 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases GISAAA 35(11),11,1970

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
CLCHAU 19,361,1973
TOXICOLOGY REVIEW
ENTOX* -,331,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80251;
Number of Industries 35;
Total Number of Facilities 995;
Number of Occupations 31;
Total Number of Employees Exposed 6,536
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4244;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 65
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80251;
Number of Industries 48;
Total Number of Facilities 2,277;
Number of Occupations 74;
Total Number of Employees Exposed 41,637;
Total Number of Female Employees Exposed 4,576

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS PB/93/110674/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE**

CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

NIOSH PROFILE (BORON and ITS COMPOUNDS), SRC, 10/77

RTECS Compound Description:
Reproductive Effector

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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 4.95 mg/kg (1-22 day pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death	VCVN1* -,195,1988

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 11 gm/kg	N/R	GTPZAB 35(2),42,1991
intraperitoneal rat	lethal dose (50 percent kill): 7 gm/kg	N/R	GTPZAB 35(2),42,1991
oral cat	lethal dose (50 percent kill): 250 mg/kg	N/R	GISAAA 35(11),11,1970
oral dog	lethal dose (50 percent kill): 310 mg/kg	N/R	GISAAA 35(11),11,1970
oral guinea pig	lethal dose (50 percent kill): 310 mg/kg	N/R	GISAAA 35(11),11,1970
oral mammal (species unspecified)	lethal dose (50 percent kill): 300 mg/kg	N/R	GISAAA 40(9),49,1975
oral mouse	lethal dose (50 percent kill): 560 mg/kg	N/R	GISAAA 35(11),11,1970
oral rat	lethal dose (50 percent kill): 650 mg/kg	N/R	GISAAA 35(11),11,1970
oral rabbit	lethal dose (50 percent kill): 310 mg/kg	N/R	GISAAA 35(11),11,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 10,560 痢/m³/4 hour/17 week- intermittent	Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	GTPZAB 35(2),42,1991
oral rat	lowest published toxic dose: 32 gm/kg/30 day- intermittent	Brain and Coverings: Other degenerative changes Cardiac: Other changes Liver: Liver function tests impaired	GTPZAB 35(2),42,1991
oral rabbit	lowest published toxic dose: 2,821 mg/kg/13 week- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	GISAAA 35(11),11,1970

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		KOTTAM 11,1300,1975
TOXICOLOGY REVIEW		CLCHAU 19,361,1973
TOXICOLOGY REVIEW		ENTOX* -,331,2005

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 80251; Number of Industries 35; Total Number of Facilities 995; Number of Occupations 31; Total Number of Employees Exposed 6,536
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X4244; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 65
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 80251; Number of Industries 48; Total Number of Facilities 2,277; Number of Occupations 74; Total Number of Employees Exposed 41,637; Total Number of Female Employees Exposed 4,576

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110674/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
CLCHAU	Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GISAAA	Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
KOTTAM	Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
VCVN1*	"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.