RTECS:DV8750000 The Registry of Toxic Effects of Chemical Substances

3,3'4,4' - Biphenyltetramine

RTECS #: DV8750000

CAS #: 91-95-2

UPDATE: February 2008 MW: 214.30 MF: C₁₂H₁₄N₄

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

(1,1' - Biphenyl) - 3,3',4,4' - tetramine (9CI)

3,3',4,4' - Diphenyltetramine

3,3',4,4' - Tetraaminobiphenyl

3,3',4,4' - Tetraaminodiphenyl

3,3' - Diaminobenzidene

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis intraperitoneal
mouse 100 mg/kg MUREAV 319,19,1993
DNA adduct Escherichia coli 20 痠ol/L MUREAV 89,95,1981
DNA damage human lymphocyte 100 痠ol/L/2 hour TOSCF2 72,283,2003
unscheduled DNA synthesis rat liver 500 痠ol/L ENMUDM 3,11,1981
mutation in microorganisms Salmonella typhimurium 25 痢/plate (-enzymatic activation step) MUREAV 158,19,1985
mutation in microorganisms Salmonella typhimurium 3 痢/plate (+enzymatic activation step) TOSCF2 56,351,2000
mutation in microorganisms Saccharomyes cerevisiae 140 痠ol/L (-enzymatic activation step) MGGEAE 174,39,1979
other mutation test systems intraperitoneal
mouse 100 mg/kg MUREAV 319,19,1993

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 9,000 mg/kg/27 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors CNREA8 28,924,1968

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published lethal concentration: 260 mg/m³/4 hour Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Cyanosis

Kidney, Ureter, and Bladder: Other changes in urine composition NTIS OTS0537196
oral
mouse lethal dose (50 percent kill): 1,834 mg/kg N/R GISAAA 46(1),94,1981
oral
rat lowest published lethal dose: 3 gm/kg N/R CNREA8 26,619,1966

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TCMUD8 23(Suppl 1),187,2003
TOXICOLOGY REVIEW
MUREAV 612,58,2006

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - SWITZERLAND MAK- week 0.003 ppm (0.03 mg/m³), DEC2006

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5448;
Number of Industries 1;
Total Number of Facilities 38;
Number of Occupations 2;
Total Number of Employees Exposed 135;
Total Number of Female Employees Exposed 95

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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SYNONYMS:
(1,1' - Biphenyl) - 3,3',4,4' - tetramine (9CI) 3,3',4,4' - Diphenyltetramine 3,3',4,4' - Tetraaminobiphenyl	3,3',4,4' - Tetraaminodiphenyl 3,3' - Diaminobenzidene

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	intraperitoneal mouse	100 mg/kg	MUREAV 319,19,1993
DNA adduct	Escherichia coli	20 痠ol/L	MUREAV 89,95,1981
DNA damage	human lymphocyte	100 痠ol/L/2 hour	TOSCF2 72,283,2003
unscheduled DNA synthesis	rat liver	500 痠ol/L	ENMUDM 3,11,1981
mutation in microorganisms	Salmonella typhimurium	25 痢/plate (-enzymatic activation step)	MUREAV 158,19,1985
mutation in microorganisms	Salmonella typhimurium	3 痢/plate (+enzymatic activation step)	TOSCF2 56,351,2000
mutation in microorganisms	Saccharomyes cerevisiae	140 痠ol/L (-enzymatic activation step)	MGGEAE 174,39,1979
other mutation test systems	intraperitoneal mouse	100 mg/kg	MUREAV 319,19,1993

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 9,000 mg/kg/27 day- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors	CNREA8 28,924,1968

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published lethal concentration: 260 mg/m³/4 hour	Behavioral: Muscle weakness Lung, Thorax, or Respiration: Cyanosis Kidney, Ureter, and Bladder: Other changes in urine composition	NTIS** OTS0537196
oral mouse	lethal dose (50 percent kill): 1,834 mg/kg	N/R	GISAAA 46(1),94,1981
oral rat	lowest published lethal dose: 3 gm/kg	N/R	CNREA8 26,619,1966

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		TCMUD8 23(Suppl 1),187,2003
TOXICOLOGY REVIEW		MUREAV 612,58,2006

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - SWITZERLAND	MAK- week 0.003 ppm (0.03 mg/m³), DEC2006

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X5448; Number of Industries 1; Total Number of Facilities 38; Number of Occupations 2; Total Number of Employees Exposed 135; Total Number of Female Employees Exposed 95

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
CNREA8	Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
ENMUDM	Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GISAAA	Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MGGEAE	Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TCMUD8	Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOSCF2	Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-