The Registry of Toxic Effects of Chemical Substances

D - Gluconic acid, compd. with N,N'' - bis (4 - chlorophenyl) - 3,12 - diimino - 2,4,11,13 - tetraazatetradecane diimidamide (2:1)

RTECS #: DU1950000

CAS #: 18472-51-0

UPDATE: February 2008 MW: 897.88 MF: C22H30Cl2N10•2C6H12O7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1' - Hexamethylenebis (5 - (p - chlorophenyl) biguanide) digluconate
  2. 1,6 - Bis (5 - (p - chlorophenyl) biguandino) hexane digluconate
  3. Abacil
  4. Arlacide G
  5. Bacticlens
  6. Biguanide, 1,1' - hexamethylenebis (5 - (p - chlorophenyl) - , digluconate
  7. Caswell No. 481G
  8. Chlorhexidine digluconate
  9. Chlorhexidine di - D - gluconate
  10. Chlorhexidine gluconate
  11. Chlorhexidin glukonatu (Czech)
  12. Corsodyl
  13. Disteryl
  1. Gluconic acid, compd. with 1,1' - hexamethylene bis (5 - (p - chlorophenyl) biguanide) (2:1) , D - (8CI)
  2. Hibiclens
  3. Hibidil
  4. Hibiscrub
  5. Hibitane 5
  6. Orahexal
  7. Peridex
  8. Peridex (antiseptic)
  9. Plac out
  10. Plurexid
  11. Septeal
  12. Unisept


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 1 mg/L ESKGA2 32,171,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 200 mg/m3 Lung, Thorax, or Respiration: Other changes TOVEFN (2),36,2001
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 120 mg/m3 Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression 		TOVEFN (2),36,2001
inhalation
mouse 		lowest published toxic concentration: 120 mg/m3/4 hour Behavioral: Somnolence (general depressed activity) TOVEFN (2),36,2001
inhalation
rat 		lowest published toxic concentration: 120 mg/m3/4 hour Behavioral: Somnolence (general depressed activity) TOVEFN (2),36,2001
intratracheal
rat 		lowest published toxic dose: 300 µg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage 		DCTODJ 1,1,2006
intravenous
man 		lowest published toxic dose: 13 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory depression 		JTCTDW 39,77,2001
intravenous
man 		lowest published toxic dose: 13 mg/kg Lung, Thorax, or Respiration: Respiratory obstruction CTOXAO 39,77,2001
intravenous
mouse 		lethal dose (50 percent kill): 12,900 µg/kg N/R NIIRDN 6,255,1982
intravenous
rat 		lethal dose (50 percent kill): 24,200 µg/kg N/R NIIRDN 6,255,1982
ocular
mammal (species unspecified) 		lowest published toxic dose: 100 pph Eye: Other eye effects TOVEFN (2),36,2001
oral
mouse 		lethal dose (50 percent kill): 1,260 mg/kg N/R NIIRDN 6,255,1982
oral
mouse 		lethal dose (50 percent kill): 2,215 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression 		TOVEFN (2),36,2001
oral
rat 		lethal dose (50 percent kill): 2 gm/kg N/R NIIRDN 6,255,1982
oral
rat 		lethal dose (50 percent kill): 2,430 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression 		TOVEFN (2),36,2001
subcutaneous
mouse 		lethal dose (50 percent kill): 1,140 mg/kg N/R NIIRDN 6,255,1982
subcutaneous
rat 		lethal dose (50 percent kill): 3,320 mg/kg N/R NIIRDN 6,255,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 566,209,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,242,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3093;
Number of Industries 5;
Total Number of Facilities 4,592;
Number of Occupations 36;
Total Number of Employees Exposed 643,404;
Total Number of Female Employees Exposed 561,783


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown

RTECS Compound Description:
   Drug
   Mutagen
   Human Data

ALT CAS #: 14007-07-9
ALT CAS #: 60042-57-1
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