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Biguanide, 1,1' - hexamethylenebis (5 - (p - chlorophenyl) - , diacetate

RTECS #: DU1930000

CAS #: 56-95-1

UPDATE: August 2003 MW: 625.64 MF: C22H30Cl2N10•2C2H4O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. 1,1' - Hexamethylenebis (5 - (p - chlorophenyl) biguanide) diacetate
  2. 1,6 - Bis (5 - (p - chlorophenyl) biguandino) hexane diacetate
  3. 1,6 - Di (4' - chlorophenyldiguanidino) hexane diacetate
  4. 10,040 Diacetate
  1. Chlorhexidine acetate
  2. Chlorhexidine diacetate
  3. Hibitane diacetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour mild JACTDZ 4(6),309,1985


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 38 mg/kg N/R BJPCAL 9,192,1954
intravenous
mouse 		lethal dose (50 percent kill): 25 mg/kg N/R BJPCAL 9,192,1954
oral
mouse 		lethal dose (50 percent kill): 2 gm/kg N/R BJPCAL 9,192,1954
subcutaneous
mouse 		lethal dose (50 percent kill): 325 mg/kg N/R BJPCAL 9,192,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,242,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81769;
Number of Industries 1;
Total Number of Facilities 232;
Number of Occupations 2;
Total Number of Employees Exposed 1,737
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81769;
Number of Industries 1;
Total Number of Facilities 76;
Number of Occupations 2;
Total Number of Employees Exposed 1,050;
Total Number of Female Employees Exposed 727


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

Used as an antimicrobial, disinfectant, and ophthalmic and urinary bladder irrigant

RTECS Compound Description:
   Drug
   Hormone
   Primary Irritant

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