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Biguanide, 1,1' - hexamethylenebis (5 - (p - chlorophenyl) -

RTECS #: DU1925000

CAS #: 55-56-1

UPDATE: August 2007 MW: 505.52 MF: C22H30Cl2N10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,1' - Hexamethylenebis (5 - (p - chlorophenyl) biguanide)
  2. 1,6 - Bis (5 - (p - chlorophenyl) biguandino) hexane
  3. 1,6 - Bis (p - chlorophenyldiguanido) hexane
  4. 1,6 - Di (4' - chlorophenyldiguanido) hexane
  5. 2,4,11,13 - Tetraazatetradecanediimidamide, N,N'' - bis (4 - chlorophenyl) - 3,12 - diimino -
  6. Chlorhexidin (Czech)
  7. Chlorhexidine
  1. Fimeil
  2. Hexadol
  3. Nolvasan
  4. Rotersept
  5. Soretol
  6. Sterilon
  7. Tubulicid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		1,500 µg/3 day- intermittent mild 85DKA8 -,127,1977
skin
man 		0.2% AANEAB 45,1290,2001


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Escherichia coli 7 µmol/disc CBINA8 28,249,1979
mutation in microorganisms Salmonella typhimurium 14,300 pmol/plate (+/-enzymatic activation step) CBINA8 28,249,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1,680 mg/kg (7 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) MEXPAG 10,361,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 44 mg/kg N/R VTYMAC 72,1330,1977
intraperitoneal
rat 		lethal dose (50 percent kill): 60 mg/kg N/R VTYMAC 72,1330,1977
intravenous
mouse 		lethal dose (50 percent kill): 24 mg/kg N/R JCPEDZ 4(5),66,1977
intravenous
rat 		lethal dose (50 percent kill): 21 mg/kg Behavioral: Convulsions or effect on seizure threshold RMISDU 23,45,1980
intravenous
rabbit 		lethal dose : >8 mg/kg N/R VTYMAC 72,1330,1977
oral
mouse 		lethal dose (50 percent kill): 2,515 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema RMISDU 23,45,1980
oral
rat 		lethal dose (50 percent kill): 9,200 µL/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Ulceration or bleeding from stomach 		YACHDS 6,2599,1978
subcutaneous
mouse 		lethal dose (50 percent kill): 632 mg/kg N/R JCPEDZ 4(5),66,1977
subcutaneous
rat 		lethal dose (50 percent kill): >1 gm/kg Gastrointestinal: Changes in structure or function of salivary glands JCPEDZ 4(5),66,1977
skin
man 		lowest published toxic dose: 0.5 pph Immunological Including Allergic: Anaphylaxis (multiple organ involvement) AANEAB 45,1290,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 150 µL/kg/30 day- intermittent Blood: Changes in leukocyte (WBC) count

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins 		YACHDS 6,2599,1978


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
AJINC* 34,627,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84812;
Number of Industries 1;
Total Number of Facilities 8;
Number of Occupations 1;
Total Number of Employees Exposed 32;
Total Number of Female Employees Exposed 32


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
AJINC* American Journal of Infection Control (St. Louis, Mosby) V.8- 1980-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
JCPEDZ Journal of Clinical Periodontology. (Munksgaard International Publishers, POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1974-
MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO.
RMISDU International Congress and Symposium Series - Royal Society of Medicine Services Limited. (Royal Society of Medicine Services Ltd., 7E. 60th St., New York, NY 10022) No.1- 1978-
VTYMAC VM/SAC, Veterinary Medicine and Small Animal Clinician. (Veterinary Medicine Publishing Co., 690 S. 4th St., POB 13265, Edwardsville, KS 66113) V.59- 1964-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-

Used as an antibacterial and antifungal

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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