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Benzyl alcohol, 3,5 - di - tert - butyl - 4 - hydroxy -

RTECS #: DO0750000

CAS #: 88-26-6

UPDATE: February 2004 MW: 236.39 MF: C15H24O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2,6 - Di - tert - butyl - 4 - hydroxymethylphenol
  2. 3,5 - Di - tert - butyl - 4 - hydroxybenzyl alcohol
  3. AO 754
  4. Antioxidant 754
  1. Benzenemethanol, 3,5 - bis (1,1 - dimethylethyl) - 4 - hydroxy -
  2. Ionox 100
  3. Ionox 100 antioxidant


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition human lymphocyte 25 µmol/L BBRCA9 80,963,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published lethal dose: 7 gm/kg N/R TXAPA9 17,669,1970
oral
rat 		lowest published lethal dose: 7 gm/kg N/R TXAPA9 17,669,1970
oral
rat 		lethal dose (50 percent kill): 7,000 mg/kg N/R VCVGK* -,222,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 6,520 mg/kg/1 week- continuous Blood: Change in clotting factors TXAPA9 46,935,1982
oral
rat 		lowest published toxic dose: 127,750 mg/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGK* -,222,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1085;
Number of Industries 1;
Total Number of Facilities 45;
Number of Occupations 3;
Total Number of Employees Exposed 5,124;
Total Number of Female Employees Exposed 356


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Mutagen
   Human Data

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