The Registry of Toxic Effects of Chemical Substances

Benzyl alcohol, alpha - methyl -

RTECS #: DO9275000

CAS #: 98-85-1

UPDATE: November 2007 MW: 122.18 MF: C8H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Fenylethanol (Czech)
  2. 1 - Phenethyl alcohol
  3. 1 - Phenylethanol
  4. Benzenemethanol, alpha - methyl -
  5. Ethanol, 1 - phenyl -
  6. Fenyl - methylkarbinol (Czech)
  7. Methanol, methylphenyl -
  1. Methylphenylcarbinol
  2. NCI - C55685
  3. Phenylmethylcarbinol
  4. Styrallyl alcohol
  5. Styralyl alcohol
  6. alpha - Methylbenzenemethanol
  7. alpha - Phenethyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		2 mg severe AJOPAA 29,1363,1946
skin
rabbit 		10 mg/24 hour open irritation test severe JIHTAB 26,269,1944
skin
rabbit 		500 mg/24 hour moderate FCTXAV 12,995,1974


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 1 gm/L NTPTR* NTP-TR-369,1990
mutation in mammalian somatic cells mouse lymphocyte 250 mg/kg NTPTR* NTP-TR-369,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 386 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		NTPTR* NTP-TR-369,1990
oral
rat 		lowest published toxic dose: 386,250 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		NTIS** PB90-241092


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
dog 		lowest published lethal dose: 200 mg/kg N/R JPETAB 15,129,1920
oral
mouse 		lethal dose (50 percent kill): 558 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		GTPZAB 29(11),51,1985
oral
rat 		lethal dose (50 percent kill): 400 mg/kg N/R JIHTAB 26,269,1944
subcutaneous
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R AIPTAK 116,154,1958
skin
guinea pig 		lethal dose (50 percent kill): >15 mL/kg N/R 34ZIAG -,695,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 12 gm/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-369,1990
oral
rat 		lowest published toxic dose: 97,500 mg/kg/13 week- intermittent Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-369,1990
oral
rat 		lowest published toxic dose: 24 gm/kg/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-369,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
MUREAV 635,81,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9925;
Number of Industries 17;
Total Number of Facilities 653;
Number of Occupations 15;
Total Number of Employees Exposed 15,991;
Total Number of Female Employees Exposed 1,959


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a cosmetic and perfume ingredient
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-369,1990
NTP Carcinogenesis Studies (gavage);no evidence:mouse NTPTR* NTP-TR-369,1990


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

Used as a cosmetic and perfume ingredient

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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