CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Benzyl alcohol, m - hydroxy - alpha - ( (methylamino) methyl) - , ( - ) -

RTECS #: DO7175000

CAS #: 59-42-7

UPDATE: February 2009 MW: 167.23 MF: C9H13NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. ( - ) - Phenylephrine
  2. ( - ) - m - Hydroxy - alpha - (methylaminomethyl) benzyl alcohol
  3. ( - ) - m - Oxedrine
  4. Benzenemethanol, 3 - hydroxy - alpha - ( (methylamino) methyl) - , (R) - (9CI)
  5. Isophrin
  6. Mesaton
  7. Mesatone
  8. Metaoxedrin
  9. Metaoxedrine
  10. Metasympatol
  11. Metasynephrine
  1. Mezaton
  2. Neosynephrine
  3. Phenylephrine
  4. R ( - ) - Phenylephrine
  5. Visadron
  6. l - (3 - Hydroxyphenyl) - N - methylethanolamine
  7. l - 1 - (m - Hydroxyphenyl) - 2 - methylaminoethanol
  8. l - alpha - Hydroxy - beta - methylamino - 3 - hydroxy - l - ethylbenzene
  9. l - m - Hydroxy - alpha - ( (methylamino) methyl) benzyl alcohol
  10. m - Methylaminoethanolphenol
  11. m - Oxedrine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
domestic animal 		lowest published toxic dose: 20 µg/kg (16 week pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina AJOGAH 143,170,1982
intravenous
domestic animal 		lowest published toxic dose: 40 µg/kg (16 week pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) AJOGAH 143,170,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraarterial
man 		lowest published toxic dose: 1.3 ng/kg Vascular: Regional or general arteriolar constriction

Vascular: Measurement of regional blood flow 		CEXPB9 27,25,2000
intraarterial
rat 		lowest published toxic dose: 267 µg/kg Vascular: Measurement of regional blood flow JAPTO* 25,479,2005
intraduodenal
rat 		lethal dose (50 percent kill): 65 mg/kg N/R AIPTAK 180,155,1969
intramuscular
mouse 		lowest published toxic dose: 0.1 mg/kg Biochemical: Metabolism (intermediary): Other carbohydrates FATOAO 55,44,1992
intramuscular
mouse 		lowest published toxic dose: 1 mg/kg Endocrine: Hyperglycemia FATOAO 55,44,1992
intramuscular
rabbit 		lowest published toxic dose: 0.1 mg/kg Biochemical: Metabolism (intermediary): Other carbohydrates FATOAO 55,44,1992
intraperitoneal
mouse 		lowest published lethal dose: 60 mg/kg Cardiac: Other changes JPETAB 160,22,1968
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation JPETAB 313,310,2005
intrarenal
rat 		lowest published toxic dose: 1 µg/kg Vascular: Measurement of regional blood flow

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney 		ETPAEK 59,253,2007
intravenous
dog 		lowest published toxic dose: 8 µg/kg Autonomic Nervous System: Sympathomimetic

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Structural or functional change in ureter 		JPETAB 300,495,2002
intravenous
dog 		lowest published toxic dose: 50 µg/kg Cardiac: EKG changes not diagnostic of above

Vascular: BP elevation not characterized in autonomic section 		CEXPB9 32,805,2005
intravenous
man 		lowest published toxic dose: 6.4 ng/kg/5 minute Vascular: Regional or general arteriolar constriction

Vascular: Measurement of regional blood flow 		CEXPB9 27,25,2000
intravenous
monkey 		lowest published toxic dose: 3 µg/kg Cardiac: Pulse rate decreased with fall in BP

Vascular: BP elevation not characterized in autonomic section 		JPETAB 297,299,2001
intravenous
mouse 		lethal dose (50 percent kill): 38 mg/kg Behavioral: Change in motor activity (specific assay)

Cardiac: Pulse rate increased without fall in BP

Skin and Appendages: Other: Hair 		APTOA6 38,474,1976
intravenous
mouse 		lowest published toxic dose: 1 µg/kg Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section 		TOXIA6 45,93,2005
intravenous
mouse 		lowest published toxic dose: 10 µg/kg Vascular: BP elevation not characterized in autonomic section BJPCBM 150,29,2007
intravenous
pig 		lowest published toxic dose: 2.5 µg/kg Vascular: BP elevation not characterized in autonomic section

Vascular: Measurement of regional blood flow 		EJPHAZ 418,95,2001
intravenous
rat 		lowest published toxic dose: 100 µg/kg Eye: Mydriasis (pupilliary dilation) FATOAO 51,36,1988
intravenous
rat 		lowest published toxic dose: 1 µg/kg Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section 		TOXIA6 45,93,2005
intravenous
rat 		lowest published toxic dose: 10 µg/kg Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney JPETAB 313,1289,2005
intravenous
rat 		lowest published toxic dose: 1 µg/kg Vascular: BP elevation not characterized in autonomic section JPETAB 316,95,2006
intravenous
rat 		lowest published toxic dose: 10 µg/kg Kidney, Ureter, and Bladder: Other changes EJPHAZ 545,185,2006
intravenous
rat 		lowest published toxic dose: 0.5 µg/kg Cardiac: Change in rate

Cardiac: Cardiac output

Vascular: BP elevation not characterized in autonomic section 		CEXPB9 32,911,2005
intravenous
rabbit 		lowest published toxic dose: 30 µg/kg Eye: Mydriasis (pupilliary dilation)

Kidney, Ureter, and Bladder: Structural or functional change in ureter 		AEPPAE 372,346,2006
ocular
child 		lowest published toxic dose: 10 pph Vascular: BP elevation not characterized in autonomic section

Lung, Thorax, or Respiration: Acute pulmonary edema 		AJOPAA 134,624,2002
ocular
human 		lowest published toxic dose: 10 pph Brain and Coverings: Changes in circulation

Spinal Cord: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold 		AJOPAA 134,624,2002
ocular
human 		lowest published toxic dose: 10 pph Behavioral: Headache

Cardiac: Arrythmias (indlucing changes in conduction)

Vascular: BP elevation not characterized in autonomic section 		AJOPAA 134,624,2002
ocular
infant 		lowest published toxic dose: 5,500 µg/kg Vascular: BP elevation not characterized in autonomic section ANESAV 36,187,1972
ocular
woman 		lowest published toxic dose: 188 µg/kg Vascular: BP elevation not characterized in autonomic section ANESAV 36,187,1972
oral
rat 		lethal dose (50 percent kill): 350 mg/kg N/R AIPTAK 180,155,1969
subcutaneous
mouse 		lethal dose (50 percent kill): 875 mg/kg N/R FATOAO 28,46,1965
subcutaneous
mouse 		lowest published toxic dose: 10 mg/kg Liver: Other changes TOXID9 78,324,2004
subcutaneous
rat 		lethal dose (50 percent kill): 28 mg/kg N/R JPETAB 85,119,1945
subcutaneous
rat 		lowest published toxic dose: 12.5 mg/kg Reproductive: Maternal effects: Uterus, cervix, vagina TOXID9 66,24,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TPHSDY 24,5,2003
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
AJEMEN 22,404,2004
TOXICOLOGY REVIEW
APHRER 41,381,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80598;
Number of Industries 2;
Total Number of Facilities 97;
Number of Occupations 3;
Total Number of Employees Exposed 183
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80598;
Number of Industries 1;
Total Number of Facilities 147;
Number of Occupations 5;
Total Number of Employees Exposed 6,641;
Total Number of Female Employees Exposed 5,606


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us