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| UPDATE: November 2008 | MW: 183.23 | MF: C9H13NO3 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
| |||
MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
mutation in microorganisms
|
Escherichia coli
|
500 µg/plate (-enzymatic activation step)
|
MUREAV 467,41,2000
|
| |||
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
| |||
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
| |||
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intraperitoneal | mouse
lethal dose (50 percent kill): 7,800 µg/kg
|
N/R
|
PSEBAA 68,501,1948
|
intraperitoneal | rat
lowest published toxic dose: 6 mg/kg
|
Gastrointestinal: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport
JPHPH* 58,105,2007
|
intravenous | mouse
lethal dose (50 percent kill): 3,400 µg/kg
|
Lung, Thorax, or Respiration: Acute pulmonary edema | Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder
JPETAB 95,502,1949
|
intravenous | rat
lethal dose (50 percent kill): 70 µg/kg
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Muscle weakness Lung, Thorax, or Respiration: Dyspnea
JPETAB 95,502,1949
|
intravenous | rat
lowest published toxic dose: 10 µg/kg
|
Vascular: BP elevation not characterized in autonomic section | Vascular: Other changes
PHREP* 57,623,2005
|
intravenous | rabbit
lowest published lethal dose: 250 µg/kg
|
N/R
|
85IXA4 -,57,1948
|
subcutaneous | mouse
lowest published lethal dose: 12 mg/kg
|
N/R
|
85IXA4 -,57,1948
|
| |||
OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
|
| |||
REVIEWS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
TOXICOLOGY REVIEW
|
|
CHREAY 9,389,1931
|
TOXICOLOGY REVIEW
|
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ADVPA3 4,263,1966
|
TOXICOLOGY REVIEW
|
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AINCM* 5,132,2004
|
| ||
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
N/R
|
N/R
|
N/R
|
| ||
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
|
REFERENCE
National Occupational Exposure Survey 1983
|
National Occupational Exposure Survey 1983: Hazard Code: X4149 |
 ;Number of Industries 1; Total Number of Facilities 399; Number of Occupations 5; Total Number of Employees Exposed 8,846; Total Number of Female Employees Exposed 6,257 | |||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
|
REFERENCE
N/R
|
| ||
REFERENCES:
CODEN
|
|
REFERENCE
85IXA4
|
"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet,
D., and F. Bovet-Nitti, New York, S. Karger, 1948
|
ADVPA3
|
Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see
AVPCAQ.
|
AINCM*
|
Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000-
|
CHREAY
|
Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End
Stn., Washington, DC 20037) V.1- 1924-
|
JPETAB
|
Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E.
Preston St., Baltimore, MD 21202) V.1- 1909/10-
|
JPHPH*
|
|
MUREAV
|
Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
|
PHREP*
|
|
PSEBAA
|
Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1903/04-
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