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Benzyl alcohol, 3,5 - dihydroxy - alpha - ( (isopropylamino) methyl) - , sulfate (2:1) (salt)

RTECS #: DO2275000

CAS #: 5874-97-5

UPDATE: June 1996 MW: 520.66 MF: C22H34N2O6•H2O4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. REFERENCES:

SYNONYMS:

  1. 1,3 - Benzenediol, 5 - (1 - hydroxy - 2 - ( (1 - methylethyl) amino) ethyl) - , sulfate (2:1) salt
  2. 1 - (3,5 - Dihydroxyphenyl) - 1 - hydroxy - 2 - isopropylaminoethane sulfate
  3. 1 - (3,5 - Dihydroxyphenyl) - 2 - (isopropylamino) ethanol sulfate
  4. 3,5 - Dihydroxy - alpha - ( (isopropylamino) methyl) benzyl alcohol sulfate
  5. Alotec
  6. Alupent
  1. Metaprel
  2. Metaproterenol sulfate
  3. Novasmasol
  4. Orciprenaline sulfate
  5. TH - 152


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TJADAB 38,15,1988
oral
mouse 		lowest published toxic dose: 5 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 38,15,1988
oral
mouse 		lowest published toxic dose: 150 mg/kg (11-13 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TJADAB 38,15,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraduodenal
rat 		lethal dose (50 percent kill): 2,230 mg/kg N/R AIPTAK 180,155,1969
intravenous
mouse 		lethal dose (50 percent kill): 114 mg/kg Eye: Other eye effects

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands 		ARZNAD 11,521,1961
oral
mouse 		lethal dose (50 percent kill): 4,800 mg/kg Eye: Other eye effects

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands 		ARZNAD 11,521,1961
oral
rat 		lethal dose (50 percent kill): 5,538 mg/kg N/R TXAPA9 18,185,1971
subcutaneous
mouse 		lethal dose (50 percent kill): 290 mg/kg Eye: Other eye effects

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands 		ARZNAD 11,521,1961
subcutaneous
rat 		lethal dose (50 percent kill): >4 gm/kg N/R AIPTAK 180,155,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3133;
Number of Industries 1;
Total Number of Facilities 1,204;
Number of Occupations 7;
Total Number of Employees Exposed 23,118;
Total Number of Female Employees Exposed 9,688


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a beta-adrenoceptor stimulant

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector

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