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Benzyl alcohol, alpha - ( (tert - butylamino) methyl) - 3,5 - dihydroxy - , sulfate (2:1)

RTECS #: DN9000000

CAS #: 23031-32-5

UPDATE: November 2008 MW: 512.68 MF: C12H19NO3•1/2H2O4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. 1,3 - Benzenediol, 5 - (2 - ( (1,1 - dimethylethyl) amino) - 1 - hydroxyethyl) - , sulfate (2:1) (salt)
  2. 1 - (3,5 - Dihydroxyphenyl) - 2 - tert - butylaminoethanol sulphate
  3. Brethine
  4. Bricanyl
  1. Terbutaline sulfate
  2. Terbutaline sulphate
  3. alpha - ( (tert - Butylamino) methyl) - 3,5 - dihydroxybenzyl alcohol sulfate (2:1) (salt)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 3 gm/kg (7-12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		KSRNAM 6,757,1972
oral
woman 		lowest published toxic dose: 1 mg/kg (26 week pregnant) Reproductive: Other effects on female AEMED3 26,107,1995
subcutaneous
guinea pig 		lowest published toxic dose: 20 gm/kg (11-20 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system AJOGAH 161,509,1989
subcutaneous
mouse 		lowest published toxic dose: 192 mg/kg (7-12 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		KSRNAM 6,757,1972
subcutaneous
mouse 		lowest published toxic dose: 24 mg/kg (7-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) KSRNAM 6,757,1972
subcutaneous
rat 		lowest published toxic dose: 30 mg/kg (17-19 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system LIFSAK 47,2051,1990
subcutaneous
rat 		lowest published toxic dose: 120 mg/kg (30 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands KSRNAM 6,757,1972
subcutaneous
rat 		lowest published toxic dose: 30 mg/kg (17-19 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical 		PEREBL 26,554,1989
subcutaneous
rat 		lowest published toxic dose: 30 mg/kg (17-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Respiratory system 		JDPHDH 14,307,1990
subcutaneous
woman 		lowest published toxic dose: 2,500 ng/kg (39 week pregnant) Reproductive: Other effects on female

Vascular: BP lowering not characterized in autonomic section 		AJEMEN 4,218,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 130 mg/kg N/R NIIRDN 6,500,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 220 mg/kg N/R IYKEDH 5,106,1974
intravenous
dog 		lethal dose (50 percent kill): 116 mg/kg N/R KSRNAM 6,757,1972
intravenous
mouse 		lethal dose (50 percent kill): 36 mg/kg N/R IYKEDH 5,106,1974
intravenous
rat 		lethal dose (50 percent kill): 69 mg/kg N/R IYKEDH 5,106,1974
intravenous
rat 		lowest published toxic dose: 11.4 µg/kg Cardiac: Pulse rate decreased with fall in BP

Vascular: BP lowering not characterized in autonomic section

Reproductive: Maternal effects: Uterus, cervix, vagina 		JPETAB 297,666,2001
intravenous
rabbit 		lethal dose (50 percent kill): 110 mg/kg N/R KSRNAM 6,757,1972
oral
dog 		lethal dose (50 percent kill): 1,520 mg/kg N/R KSRNAM 6,757,1972
oral
mouse 		lethal dose (50 percent kill): 205 mg/kg Autonomic Nervous System: Sympathomimetic APTOA6 31,49,1972
oral
rat 		lethal dose (50 percent kill): 8,700 mg/kg N/R IYKEDH 5,106,1974
oral
rabbit 		lethal dose (50 percent kill): >8 gm/kg N/R KSRNAM 6,757,1972
oral
woman 		lowest published toxic dose: 10 mg/kg Behavioral: Tremor

Cardiac: Pulse rate increased without fall in BP

Gastrointestinal: Nausea or vomiting 		HUTODJ 6,525,1987
subcutaneous
mouse 		lethal dose (50 percent kill): 260 mg/kg N/R IYKEDH 5,106,1974
subcutaneous
rat 		lethal dose (50 percent kill): 130 mg/kg N/R NIIRDN 6,500,1982
subcutaneous
woman 		lowest published toxic dose: 50 µg/kg Cardiac: EKG changes not diagnostic of above NEJMAG 296,821,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 262.5 mg/kg/6 week- intermittent Cardiac: Pulse rate decreased with fall in BP

Vascular: BP lowering not characterized in autonomic section 		JCPCBR 16,361,1976
oral
rat 		lowest published toxic dose: 4,650 mg/kg/31 day- intermittent Cardiac: Changes in heart weight

Lung, Thorax, or Respiration: Changes in lung weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		OYYAA2 13,469,1977
oral
rat 		lowest published toxic dose: 312 gm/kg/26 week- intermittent Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		KSRNAM 6,757,1972
subcutaneous
rat 		lowest published toxic dose: 6,500 mg/kg/30 day- intermittent Cardiac: Changes in heart weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count 		KSRNAM 6,757,1972
subcutaneous
rat 		lowest published toxic dose: 40 mg/kg/4 day- intermittent Brain and Coverings: Other degenerative changes

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Metabolism (intermediary): Other proteins 		TXAPA9 203,132,2005
subcutaneous
rat 		lowest published toxic dose: 40 mg/kg/4 day- intermittent Cardiac: Other changes BDERB* 68,449,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4190;
Number of Industries 1;
Total Number of Facilities 189;
Number of Occupations 5;
Total Number of Employees Exposed 3,489;
Total Number of Female Employees Exposed 1,836


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
BDERB*
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JCPCBR Journal of Clinical Pharmacology. (Hall Assoc., PO Box 482, Stamford, CT 06904) V.13- 1973-
JDPHDH Journal of Developmental Physiology. (Oxford University Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1967-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used a beta-adrenergic receptor agonist

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

ALT CAS #: 98225-49-1
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