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Benzyl alcohol, alpha - (aminomethyl) - 3,4 - dihydroxy - , ( - ) - , tartrate (1:1)

RTECS #: DN6750000

CAS #: 51-40-1

UPDATE: May 2008 MW: 319.30 MF: C8H11NO3•C4H6O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. REFERENCES:

SYNONYMS:

  1. ( - ) - Noradrenaline acid tartrate
  2. ( - ) - Noradrenaline bitartrate
  3. ( - ) - Noradrenaline bitartrate monohydrate
  4. ( - ) - Noradrenaline tartrate
  5. ( - ) - Norepinephrine bitartrate
  6. ( - ) - Norepinephrine tartrate
  7. L - Noradrenaline bitartrate
  8. Levarterenol bitartrate
  9. Noradrenaline acid tartrate
  1. Noradrenaline bitartrate
  2. Noradrenaline hydrogen tartrate
  3. Noradrenaline tartrate
  4. Noradrenaline, tartrate (1:1)
  5. Norepinephrine bitartrate
  6. Norepinephrine tartrate
  7. l - Arterenol bitartrate
  8. l - Noradrenaline tartrate
  9. l - Norepinephrine bitartrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in mammalian somatic cells mouse lymphocyte 100 mg/L EMMUEG 11,523,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 26,800 µg/kg N/R DPHFAK 23,435,1971
intravenous
human 		lowest published toxic dose: 4.2 ng/kg Vascular: Measurement of regional blood flow CLPTAT 67,299,2000
intravenous
mouse 		lethal dose (50 percent kill): 1,025 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		EJPHAZ 9,289,1970
intravenous
rat 		lethal dose (50 percent kill): 210 µg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		YACHDS 7,627,1979
intravenous
rat 		lowest published toxic dose: 0.1 mg/kg Vascular: BP elevation not characterized in autonomic section BPBLEO 30,96,2007
intravenous
rat 		lowest published toxic dose: 0.1 mg/kg Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section 		BPBLEO 30,96,2007
intravenous
rat 		lowest published toxic dose: 3,193 ng/kg Cardiac: Change in rate FCLPH* 18,309,2004
subcutaneous
rat 		lowest published lethal dose: 3,987 µg/kg Behavioral: Excitement JPETAB 95,155,1949


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5302;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 628;
Total Number of Female Employees Exposed 314


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
DPHFAK Dissertationes Pharmaceuticae et Pharmacologicae. (Warsaw, Poland) V.18-24, 1966-72. For publisher information, see PJPPAA.
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-

RTECS Compound Description:
   Drug
   Mutagen
   Human Data

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