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Benzyl alcohol, alpha - (aminomethyl) - 3,4 - dihydroxy - , ( - ) -

RTECS #: DN5950000

CAS #: 51-41-2

UPDATE: May 2009 MW: 169.20 MF: C8H11NO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. ( - ) - Noradrec
  2. ( - ) - Noradrenaline
  3. ( - ) - Norepinephrine
  4. ( - ) - alpha - (Aminomethyl) protocatechuyl alcohol
  5. (R) - 4 - (2 - Amino - 1 - hydroxyethyl) - 1,2 - benzenediol
  6. 1,2 - Benzenediol, 4 - (2 - amino - 1 - hydroxyethyl) - , (R) - (9CI)
  7. Adrenor
  8. Aktamin
  9. Arterenol
  10. D - ( - ) - Noradrenaline
  11. Levarterenol
  12. Levoarterenol
  13. Levonoradrenaline
  14. Levonorepinephrine
  15. Levophed
  1. Noradrenalin
  2. Noradrenalina (Italian)
  3. Noradrenaline
  4. Noradrenline
  5. Norartrinal
  6. Norepinephrine
  7. Norepirenamine
  8. Sympathin E
  9. l - 1 - (3,4 - Dihydroxyphenyl) - 2 - aminoethanol
  10. l - 2 - Amino - 1 - (3,4 - dihydroxyphenyl) ethanol
  11. l - 3,4 - Dihydroxyphenylethanolamine
  12. l - Arterenol
  13. l - Noradrenaline
  14. l - Norepinephrine
  15. l - alpha - (Aminomethyl) - 3,4 - dihydroxybenzyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis parenteral
silkworm 		10 mmol/L ENZYAS 41,183,1971
DNA damage human lymphocyte 10 µmol/L/30 minute TCMUD8 23(Suppl 2),69,2003
DNA damage human sperm 10 µmol/L/1 hour MUTAEX 19,325,2004
DNA damage rat lung 25 µmol/L ABCHA6 39,795,1975
DNA inhibition human other cell types 5,800 nmol/L CNREA8 40,1414,1980
DNA inhibition mouse other cell types 5,800 nmol/L CNREA8 40,1414,1980
mutation in microorganisms Escherichia coli 1 mg/plate (-enzymatic activation step) MUREAV 467,41,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 8 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Behavioral JCPPAV 58,309,1964
intravenous
guinea pig 		lowest published toxic dose: 10 µg/kg (63 day pregnant) Reproductive: Other effects on female

Vascular: Measurement of regional blood flow

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) 		JRPFA4 66,23,1982
intravenous
rat 		lowest published toxic dose: 60 µg/kg (8 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina DPTHDL 7(Suppl 1),72,1984
intravenous
rat 		lowest published toxic dose: 1 µg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 124,887,2002
subcutaneous
hamster 		lowest published toxic dose: 2 mg/kg (7-10 day pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system TJADAB 9,A19,1974
subcutaneous
hamster 		lowest published toxic dose: 2 mg/kg (7-10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 23,287,1981
subcutaneous
mouse 		lowest published toxic dose: 16 mg/kg (7-10 day pregnant) Reproductive: Effects on fertility: Other measures of fertility JOENAK 45(Suppl),viii,1969


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraarterial
rabbit 		lowest published toxic dose: 30 ng/kg Vascular: Measurement of regional blood flow

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney 		CEXPB9 29,873,2002
intraarterial
rabbit 		lowest published toxic dose: 60 ng/kg Vascular: Measurement of regional blood flow

Kidney, Ureter, and Bladder: Other changes 		CEXPB9 30,812,2003
intracerebral
rat 		lowest published toxic dose: 27 µg/kg/1 minute Behavioral: Food intake (animal) JPETAB 317,562,2006
intraperitoneal
mouse 		lethal dose (50 percent kill): 6 mg/kg N/R NIIRDN 6,567,1982
intraperitoneal
rat 		lowest published toxic dose: 0.25 mg/kg Cardiac: Other changes FATOAO 50,41,1987
intraperitoneal
rat 		lowest published toxic dose: 60 µg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) JPETAB 305,225,2003
intrarenal
dog 		lowest published toxic dose: 50 ng/kg Vascular: Measurement of regional blood flow JPETAB 303,117,2002
intrarenal
rat 		lowest published toxic dose: 100 ng/kg Vascular: Measurement of regional blood flow

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney 		ETPAEK 59,253,2007
intravenous
cat 		lowest published toxic dose: 3 µg/kg Vascular: BP elevation not characterized in autonomic section FATOAO 51,45,1988
intravenous
man 		lowest published toxic dose: 171.4 ng/kg/6 minute Vascular: Regional or general arteriolar constriction EJCPAS (),A51,1999
intravenous
monkey 		lowest published toxic dose: 7.5 mL/kg/2 hour Cardiac: Cardiomyopathy including infarction

Cardiac: EKG changes not diagnostic of above

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOXID9 72(Suppl 1),243,2003
intravenous
mouse 		lethal dose (50 percent kill): 550 µg/kg N/R AEPPAE 226,493,1955
intravenous
mouse 		lowest published toxic dose: 0.3 µg/kg Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section 		BJPCBM 150,29,2007
intravenous
rat 		lethal dose (50 percent kill): 100 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea 		JPETAB 95,502,1949
intravenous
rat 		lowest published toxic dose: 2.03 µg/kg Vascular: BP elevation not characterized in autonomic section

Vascular: Measurement of regional blood flow 		EJPHAZ 418,95,2001
intravenous
rat 		lowest published toxic dose: 20 µg/kg/10 minute Vascular: BP elevation not characterized in autonomic section

Vascular: Other changes 		EJPHAZ 455,143,2002
intravenous
rat 		lowest published toxic dose: 1 µg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct

Vascular: BP elevation not characterized in autonomic section 		JRPFA4 124,887,2002
intravenous
rat 		lowest published toxic dose: 20 µg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct REPRD* 124,887,2002
intravenous
rat 		lowest published toxic dose: 0.5 mg/kg/30 minute Vascular: Measurement of regional blood flow BJCAAI 90,549,2004
intravenous
rat 		lowest published toxic dose: 0.25 µg/kg Vascular: BP elevation not characterized in autonomic section JOETD7 97,503,2005
intravenous
rat 		lowest published toxic dose: 90 µg/kg/30 minute Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) JPETAB 305,225,2003
intravenous
rat 		lowest published toxic dose: 40 µg/kg Cardiac: Pulse rate increased without fall in BP

Vascular: BP elevation not characterized in autonomic section 		EJPHAZ 510,107,2005
intravenous
rat 		lowest published toxic dose: 16,750.8 ng/kg Cardiac: Pulse rate increased without fall in BP

Cardiac: Change in force of contraction

Vascular: BP elevation not characterized in autonomic section 		EJPHAZ 528,132,2005
intravenous
rat 		lowest published toxic dose: 40 µg/kg/10 minute Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section

Vascular: Other changes 		AEPPAE 373,376,2006
intravenous
rat 		lowest published toxic dose: 2 µg/kg Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section

Vascular: Measurement of regional blood flow 		PHMCAA 68,17,2003
intravenous
rat 		lowest published toxic dose: 63.33 µg/kg/100 minute Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section

Vascular: BP lowering not characterized in autonomic section 		PHMCAA 72,213,2004
intravenous
rat 		lowest published toxic dose: 10 µg/kg Vascular: BP elevation not characterized in autonomic section

Vascular: Other changes 		PHREP* 58,540,2006
intravenous
rat 		lowest published toxic dose: 10 µg/kg Vascular: BP elevation not characterized in autonomic section

Blood: Other changes 		PHREP* 58,908,2006
intravenous
rabbit 		lowest published lethal dose: 250 µg/kg N/R AIPTAK 41,365,1931
intravenous
rabbit 		lowest published toxic dose: 1.5 µg/kg/15 minute Vascular: BP elevation not characterized in autonomic section

Vascular: Measurement of regional blood flow

Reproductive: Maternal effects: Uterus, cervix, vagina 		JPETAB 310,141,2004
oral
mouse 		lethal dose (50 percent kill): 20 mg/kg N/R APTOA6 31,49,1972
subcutaneous
mouse 		lethal dose (50 percent kill): 5 mg/kg N/R NATWAY 56,615,1969
unreported route
rat 		lowest published toxic dose: 169.2 ng/kg Vascular: BP elevation not characterized in autonomic section NSAPCC 369(Suppl 1),R25,2004


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 22.5 mg/kg/15 day- intermittent Cardiac: Changes in heart weight CYLPDN 21,850,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TPHSDY 23,83,2002
TOXICOLOGY REVIEW
TPHSDY 24,199,2003
TOXICOLOGY REVIEW
JOPSEQ 20,708,2006
TOXICOLOGY REVIEW
JOPSEQ 20,602,2006
TOXICOLOGY REVIEW
JOPSEQ 20,194,2006
TOXICOLOGY REVIEW
AINCM* 5,132,2004
TOXICOLOGY REVIEW
EJPHAZ 545,22,2006
TOXICOLOGY REVIEW
HUTOX* -,335,1996
TOXICOLOGY REVIEW
MUREAV 681,3,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1103;
Number of Industries 1;
Total Number of Facilities 43;
Number of Occupations 2;
Total Number of Employees Exposed 85
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1103;
Number of Industries 2;
Total Number of Facilities 68;
Number of Occupations 3;
Total Number of Employees Exposed 613;
Total Number of Female Employees Exposed 175


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AINCM* Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980-
EJCPAS European Journal of Clinical Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENZYAS Enzymologia. (The Hague, Netherlands) V.1-43, 1936-72.
ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
HUTOX*
JCPPAV Journal of Comparative and Physiological Psychology. (Washington, DC) V.40-96, 1947-82.
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972-
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959-
PHREP*
REPRD* Reproduction: the official journal of the Society for the Study of Fertility (Cambridge, England: Society for Reproduction and Fertility) V.121- 2001-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-

Used as a sympathomimetic vasopressor

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

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