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Benzyl alcohol, alpha - (1 - aminoethyl) - 2,5 - dimethoxy - , hydrochloride

RTECS #: DN4025000

CAS #: 61-16-5

UPDATE: December 1996 MW: 247.75 MF: C11H17NO3•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. REFERENCES:

SYNONYMS:

  1. 1 - (2,5 - Dimethoxyphenyl) - 2 - aminopropanol
  2. 2 - Amino - 1 - (2,5 - dimethoxyphenyl) - 1 - propanol hydrochloride
  3. Methoxamine hydrochloride
  4. Pressomin hydrochloride
  5. Vasoxine
  1. Vasoxine hydrochloride
  2. Vasoxyl hydrochloride
  3. alpha - (1 - Aminoethyl) - 2,5 - dimethoxybenzyl alcohol hydrochloride
  4. beta - (2,5 - Dimethoxyphenyl) - beta - hydroxyisopropylamine hydrochloride
  5. beta - Hydroxy - beta - (2,5 - dimethoxyphenyl) - isopropylamine hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 400 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		JRPFA4 58,19,1980
intratesticular
rat 		lowest published toxic dose: 400 mg/kg (21 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		JRPFA4 58,19,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 92 mg/kg Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands 		JPETAB 92,283,1948
intravenous
mouse 		lethal dose (50 percent kill): 5,030 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		EJPHAZ 9,289,1970
oral
mouse 		lowest published lethal dose: 135 mg/kg N/R 27ZIAQ -,160,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5310;
Number of Industries 1;
Total Number of Facilities 23;
Number of Occupations 3;
Total Number of Employees Exposed 988;
Total Number of Female Employees Exposed 625


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-

Used as a sympathomimetic drug

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector

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