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2 - Benzothiazolesulfenamide, N - cyclohexyl -

RTECS #: DL6250000

CAS #: 95-33-0

UPDATE: February 2008 MW: 264.43 MF: C13H16N2S2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Accelerator CZ
  2. Accicure HBS
  3. Benzothiazyl - 2 - cyclohexylsulfenamide
  4. CBS
  5. Conac A
  6. Conac S
  7. Curax
  8. Delac S
  9. Durax
  10. Ekagom CBS
  11. N - Cyclohexyl - 2 - benzothiazolesulfenamide
  12. N - Cyclohexyl - 2 - benzothiazylsulfenamide
  13. Nocceler CZ
  14. Pennac CBS
  15. Rhodifax 16
  16. Royal CBTS
  1. Sanceler CM - PO
  2. Santocure
  3. Santocure vulcanization accelerator
  4. Soxinol CZ
  5. Sulfenamide TS
  6. Sulfenax
  7. Sulfenax CB
  8. Sulfenax CB 30
  9. Sulfenax CB/K
  10. Thiohexam
  11. Vulcafor CBS
  12. Vulcafor HBS
  13. Vulkacit C
  14. Vulkacit CZ
  15. Vulkacit CZ/C
  16. Vulkacit CZ/K


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 6,065 mg/kg (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JJATDK 9,187,1989
oral
rat 		lowest published toxic dose: 4,500 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TCMUD8 16,1,1996
oral
rat 		lowest published toxic dose: 4,500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		TCMUD8 16,1,1996
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Urogenital system 		TCMUD8 16,1,1996
parenteral
rat 		lowest published toxic dose: 400 mg/kg (4-11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		BEXBAN 93,107,1982
parenteral
rat 		lowest published toxic dose: 800 mg/kg (2 day male/2 day prior to copulation) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		BEXBAN 93,107,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 76 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Blood: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratracheal
rat 		lowest published toxic dose: 250 mg/kg N/R TPKVAL 8,70,1966
intravenous
mouse 		lethal dose (50 percent kill): 32 mg/kg N/R CSLNX* NX#02243
oral
mouse 		lethal dose (50 percent kill): >8 gm/kg N/R SRTCAC 36(1-4),10,1989
oral
mouse 		lethal dose (50 percent kill): 400 mg/kg Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 12,137,1971
oral
rat 		lethal dose (50 percent kill): 5,300 mg/kg Eye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal) 		ATDAEI 1,105,1990
oral
rat 		lowest published lethal dose: 5,000 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance 		TPKVAL 8,70,1966
oral
rat 		lowest published toxic dose: 2,000 mg/kg Lung, Thorax, or Respiration: Fibrosing alveolitis

Liver: Other changes 		TPKVAL 8,70,1966
skin
rabbit 		lethal dose (50 percent kill): >7,940 mg/kg N/R ATDAEI 1,105,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 10,000 mg/kg/2 day- intermittent Blood: Other changes TPKVAL 8,70,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83305;
Number of Industries 2;
Total Number of Facilities 151;
Number of Occupations 21;
Total Number of Employees Exposed 4,465
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83305;
Number of Industries 4;
Total Number of Facilities 745;
Number of Occupations 13;
Total Number of Employees Exposed 23,173;
Total Number of Female Employees Exposed 5,215


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as accelerator for rubber
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as accelerator for rubber

NIOSH PROFILE (MERCAPTOBENZOTHIAZOLES), SRC, 3/78

RTECS Compound Description:
   Tumorigen
   Reproductive Effector

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