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2H - 1,2,4 - Benzothiadiazine, 7 - chloro - 3 - methyl - , 1,1 - dioxide

RTECS #: DK8185000

CAS #: 364-98-7

UPDATE: May 2009 MW: 230.68 MF: C8H7ClN2O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. 7 - Chloro - 3 - methyl - 2H - 1,2,4 - benzothiadiazine 1,1 - dioxide
  2. 7 - Cloro - 3 - metil - 2H - 1,2,4 - benzotiodiazina - 1,1 - diossido (Italian)
  3. Diazossido (Italian)
  4. Diazoxide
  5. Dizoxide
  1. Hyperstat
  2. Mutabase
  3. Proglicem
  4. SRG 95213


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
domestic animal 		lowest published toxic dose: 65 mg/kg (110-114 day pregnant) Reproductive: Other effects to embryo or fetus JCNDBK 11,206,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lowest published toxic dose: 200 µg/kg Behavioral: Alteration of operant conditioning EJPHAZ 487,143,2004
intraperitoneal
mouse 		lethal dose (50 percent kill): 326 mg/kg Vascular: BP lowering not characterized in autonomic section JPETAB 136,344,1962
intraperitoneal
rat 		lethal dose (50 percent kill): 510 mg/kg N/R AIPTAK 143,446,1963
intraspinal
rat 		lowest published toxic dose: 66.7 µg/kg Behavioral: Analgesia EJPHAZ 531,87,2006
intravenous
mouse 		lethal dose (50 percent kill): 228 mg/kg Vascular: BP lowering not characterized in autonomic section JPETAB 136,344,1962
intravenous
rat 		lowest published toxic dose: 10 µg/kg Vascular: BP lowering not characterized in autonomic section

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney 		JPETAB 304,507,2003
oral
mouse 		lethal dose (50 percent kill): 444 mg/kg Vascular: BP lowering not characterized in autonomic section JPETAB 136,344,1962
oral
rat 		lethal dose (50 percent kill): 980 mg/kg N/R AIPTAK 143,446,1963
subcutaneous
rat 		lowest published toxic dose: 190 µg/kg Behavioral: Analgesia EJPHAZ 489,59,2004


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ENTOX* -,789,2005
TOXICOLOGY REVIEW
HUTOX* -,395,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7114;
Number of Industries 1;
Total Number of Facilities 63;
Number of Occupations 3;
Total Number of Employees Exposed 612;
Total Number of Female Employees Exposed 395


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HUTOX*
JCNDBK Journal of Clinical Pharmacology and New Drugs. (Stamford, CT) V.11-13, 1971-73. For publisher information, see JCPCBR.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

Used as a hypotensive drug

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector

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