RTECS:DK1750000 The Registry of Toxic Effects of Chemical Substances

2H - Benzo (a) quinolizine, 3 - ethyl - 1,3,4,6,7,11b - hexahydro - 9,10 - dimethoxy - 2 - ( (1,2,3,4 - tetrahydro - 6,7 - dimethoxy - 1 - isoquinolyl) methyl) -

RTECS #: DK1750000

CAS #: 483-18-1

UPDATE: August 2007 MW: 480.71 MF: C₂₉H₄₀N₂O₄

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

MUTATION DATA:

ACUTE TOXICITY DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

( - ) - Emetine

6',7',10,11 - Tetramethoxyemetan

Cephaeline methyl ether

Emetan, 6',7',10,11 - tetramethoxy -

Emetine

NSC - 33669

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
rabbit 2,000 ppm severe AJOPAA 31,837,1948
skin
rabbit 5 mg/24 hour rinse severe TXCYAC 14,117,1979
skin
rabbit 1 pph/24 hour moderate NTIS PB274-082

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
DNA inhibition intraperitoneal
mouse 25 mg/kg JNCIAM 60,1049,1978
mutation in microorganisms other microorganisms 1,250 mg/L (-enzymatic activation step) MUREAV 21,44,1973

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 12 mg/kg N/R JPETAB 104,421,1952
intraperitoneal
rat lethal dose (50 percent kill): 12 mg/kg N/R JPETAB 104,421,1952
intravenous
cat lowest published lethal dose: 10 mg/kg N/R HBAMAK 4,1289,1935
intravenous
guinea pig lowest published lethal dose: 7 mg/kg N/R HBAMAK 4,1289,1935
intravenous
rabbit lowest published lethal dose: 2 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
cat lowest published lethal dose: 8 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
guinea pig lowest published lethal dose: 70 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
man lowest published toxic dose: 10 mg/kg/10 day Behavioral: Muscle weakness

Cardiac: Arrythmias (indlucing changes in conduction)

Gastrointestinal: Other changes CCROBU 57,423,1973
subcutaneous
rabbit lowest published lethal dose: 30 mg/kg N/R HBAMAK 4,1289,1935
unreported route
man lowest published lethal dose: 2,941 痢/kg N/R 85DCAI 2,73,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE**

TOXICOLOGY REVIEW
CRTXB2 2,159,1973
TOXICOLOGY REVIEW
DIMON* 39,678,1993

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4638;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 103;
Total Number of Female Employees Exposed 52

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

NCI Carcinogenesis Studies (ipr);inadequate studies:mouse,rat NCITR* NCI-TR-43,1977

REFERENCES:
CODEN
REFERENCE

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
CCROBU Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO.
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as an antiamebic agent

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data
   Natural Product
   Primary Irritant

ALT CAS #: 602-59-5
ALT CAS #: 24377-67-1
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SYNONYMS:
( - ) - Emetine 6',7',10,11 - Tetramethoxyemetan Cephaeline methyl ether	Emetan, 6',7',10,11 - tetramethoxy - Emetine NSC - 33669

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye rabbit	2,000 ppm	severe	AJOPAA 31,837,1948
skin rabbit	5 mg/24 hour rinse	severe	TXCYAC 14,117,1979
skin rabbit	1 pph/24 hour	moderate	NTIS** PB274-082

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
DNA inhibition	intraperitoneal mouse	25 mg/kg	JNCIAM 60,1049,1978
mutation in microorganisms	other microorganisms	1,250 mg/L (-enzymatic activation step)	MUREAV 21,44,1973

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 12 mg/kg	N/R	JPETAB 104,421,1952
intraperitoneal rat	lethal dose (50 percent kill): 12 mg/kg	N/R	JPETAB 104,421,1952
intravenous cat	lowest published lethal dose: 10 mg/kg	N/R	HBAMAK 4,1289,1935
intravenous guinea pig	lowest published lethal dose: 7 mg/kg	N/R	HBAMAK 4,1289,1935
intravenous rabbit	lowest published lethal dose: 2 mg/kg	N/R	HBAMAK 4,1289,1935
subcutaneous cat	lowest published lethal dose: 8 mg/kg	N/R	HBAMAK 4,1289,1935
subcutaneous guinea pig	lowest published lethal dose: 70 mg/kg	N/R	HBAMAK 4,1289,1935
subcutaneous man	lowest published toxic dose: 10 mg/kg/10 day	Behavioral: Muscle weakness Cardiac: Arrythmias (indlucing changes in conduction) Gastrointestinal: Other changes	CCROBU 57,423,1973
subcutaneous rabbit	lowest published lethal dose: 30 mg/kg	N/R	HBAMAK 4,1289,1935
unreported route man	lowest published lethal dose: 2,941 痢/kg	N/R	85DCAI 2,73,1970

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		CRTXB2 2,159,1973
TOXICOLOGY REVIEW		DIMON* 39,678,1993

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X4638; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 103; Total Number of Female Employees Exposed 52

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
NCI Carcinogenesis Studies (ipr);inadequate studies:mouse,rat	NCITR* NCI-TR-43,1977

REFERENCES:
CODEN	REFERENCE
85DCAI	"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AJOPAA	American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
CCROBU	Cancer Chemotherapy Reports, Part 1. (Washington, DC) V.52(6)-59, 1968-75. For publisher information, see CTRRDO.
CRTXB2	CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DIMON*	Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
HBAMAK	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
JNCIAM	Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JPETAB	Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR*	National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXCYAC	Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-