RTECS:DJ0700000 The Registry of Toxic Effects of Chemical Substances

Benzophenone, 2,4 - dihydroxy -

RTECS #: DJ0700000

CAS #: 131-56-6

UPDATE: May 2006 MW: 214.23 MF: C₁₃H₁₀O₃

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2,4 - Dihydroxybenzofenon (Czech)

2,4 - Dihydroxybenzophenone

Eastman Inhibitor DHPB

Quinsorb 010

Syntase 100

UF 1

USAF DO - 28

USAF ND - 54

Uvinul 400

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
rabbit 100 mg/24 hour moderate 85JCAE -,652,1986

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
intravenous
mouse lethal dose (50 percent kill): 85 mg/kg N/R BJPCAL 22,221,1964
oral
mouse lethal dose (50 percent kill): 2,500 mg/kg Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) VCVGK* -,470,1994
oral
rat lethal dose (50 percent kill): 8,600 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea RPZHAW 19,179,1968
oral
rat lethal dose (50 percent kill): 8,600 mg/kg Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) VCVGK* -,470,1994
subcutaneous
rat lowest published toxic dose: 47.5 mg/kg Endocrine: Estrogenic JAFCAU 18,1108,1970
unreported route
rat lowest published toxic dose: 1,000 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGK* -,470,1994

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
rat lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight TXAPA9 203,9,2005
oral
mammal (species unspecified) lowest published toxic dose: 10,200 mg/kg/85 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGK* -,470,1994
oral
rat lowest published toxic dose: 54,600 mg/kg/91 day- intermittent Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count RPZHAW 19,179,1968
skin
mouse lowest published toxic dose: 9,900 mg/kg/35 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGK* -,470,1994

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5161;
Number of Industries 8;
Total Number of Facilities 1,090;
Number of Occupations 20;
Total Number of Employees Exposed 6,623;
Total Number of Female Employees Exposed 981

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as UV light absorber in outdoor paints, varnishes, filter for photographic film

RTECS Compound Description:
Primary Irritant

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SYNONYMS:
2,4 - Dihydroxybenzofenon (Czech) 2,4 - Dihydroxybenzophenone Eastman Inhibitor DHPB Quinsorb 010 Syntase 100	UF 1 USAF DO - 28 USAF ND - 54 Uvinul 400

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye rabbit	100 mg/24 hour	moderate	85JCAE -,652,1986

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 100 mg/kg	N/R	NTIS** AD277-689
intravenous mouse	lethal dose (50 percent kill): 85 mg/kg	N/R	BJPCAL 22,221,1964
oral mouse	lethal dose (50 percent kill): 2,500 mg/kg	Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	VCVGK* -,470,1994
oral rat	lethal dose (50 percent kill): 8,600 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) Gastrointestinal: Hypermotility, diarrhea	RPZHAW 19,179,1968
oral rat	lethal dose (50 percent kill): 8,600 mg/kg	Gastrointestinal: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	VCVGK* -,470,1994
subcutaneous rat	lowest published toxic dose: 47.5 mg/kg	Endocrine: Estrogenic	JAFCAU 18,1108,1970
unreported route rat	lowest published toxic dose: 1,000 mg/kg	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,470,1994

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal rat	lowest published toxic dose: 1,500 mg/kg/3 day- intermittent	Endocrine: Estrogenic Related to Chronic Data: Changes in uterine weight	TXAPA9 203,9,2005
oral mammal (species unspecified)	lowest published toxic dose: 10,200 mg/kg/85 day- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,470,1994
oral rat	lowest published toxic dose: 54,600 mg/kg/91 day- intermittent	Liver: Changes in liver weight Blood: Pigmented or nucleated red blood cells Blood: Changes in erythrocyte (RBC) count	RPZHAW 19,179,1968
skin mouse	lowest published toxic dose: 9,900 mg/kg/35 day- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,470,1994

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X5161; Number of Industries 8; Total Number of Facilities 1,090; Number of Occupations 20; Total Number of Employees Exposed 6,623; Total Number of Female Employees Exposed 981

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN	REFERENCE
85JCAE	"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BJPCAL	British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
JAFCAU	Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RPZHAW	Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.