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2H - 1 - Benzopyran - 6 - ol, 3,4 - dihydro - 2,5,7,8 - tetramethyl - 2 - (4,8,12 - trimethyltridecyl) - , (2R - (2R* (4R*,8R*) ) ) -

RTECS #: DJ2900000

CAS #: 59-02-9

UPDATE: May 2009 MW: 430.79 MF: C29H50O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (2R,4'R,8'R) - alpha - Tocopherol
  2. (R,R,R) - alpha - Tocopherol
  3. 5,7,8 - Trimethyltocol
  4. Almefrol
  5. Antisterility vitamin
  6. Covi - Ox
  7. Covitol F 1000
  8. Denamone
  9. Emipherol
  10. Endo E
  11. Eprolin
  12. Epsilan
  13. Esorb
  14. Etamican
  15. Etavit
  16. Evion
  1. Evitaminum
  2. Ilitia
  3. Phytogermine
  4. Profecundin
  5. Spavit E
  6. Syntopherol
  7. Tokopharm
  8. Vascuals
  9. Verrol
  10. Vitamin E
  11. Vitamin E alpha
  12. Vitaplex E
  13. Vitayonon
  14. Viteolin
  15. alpha - Tocopherol
  16. d - alpha - Tocopherol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct intravenous
rat 		27 nmol/kg EXPEAM 31,1023,1975
DNA inhibition rat liver 100 µmol/L CNREA8 45,337,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
human 		lowest published toxic dose: 346.6 mg/kg (1-13 week pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) REPTED 20,85,2005
oral
rat 		lowest published toxic dose: 7,500 mg/kg (1-20 day pregnant) Reproductive: Effects on fertility: Other measures of fertility NYKZAU 69,293,1973
oral
rat 		lowest published toxic dose: 25,000 mg/kg (1-10 day pregnant) Reproductive: Other effects to embryo or fetus BDERE* 76,483,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 500 mg/kg Brain and Coverings: Changes in surface EEG

Behavioral: Anticonvulsant 		NRTXDN 28,463,2007
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg Behavioral: Rigidity (includes catalepsy) PSCHDL 181,71,2005
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		FATOAO 55,34,1992
intraperitoneal
rat 		lowest published toxic dose: 600 mg/kg Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		JAPTO* 25,8,2005
intraperitoneal
rat 		lowest published toxic dose: 40 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TXCYAC 217,240,2006
intravenous
man 		lowest published toxic dose: 257 µg/kg Vascular: Other changes CLPTAT 67,22,2000
intravenous
rat 		lowest published toxic dose: 20 mg/kg Cardiac: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		CEXPB9 30,745,2003
oral
mouse 		lethal dose (50 percent kill): >25 mL/kg N/R IJTOFN 21,51,2002
oral
rat 		lowest published toxic dose: 50 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases FATOAO 53,33,1990
oral
rat 		lowest published toxic dose: 100 mg/kg Gastrointestinal: Other changes BPBLEO 29,675,2006
oral
rat 		lowest published toxic dose: 250 mg/kg Behavioral: Change in motor activity (specific assay)

Biochemical: Metabolism (intermediary): Lipids including transport 		FCLPH* 17,703,2003
unreported route
rat 		lowest published toxic dose: 50 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		EKFAE9 56,55,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Biochemical: Metabolism (intermediary): Other TOXID9 44,45,2005
intraperitoneal
mouse 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Behavioral: Convulsions or effect on seizure threshold TOXID9 66,90,2002
intraperitoneal
mouse 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TOXID9 90,102,2006
intraperitoneal
rat 		lowest published toxic dose: 20 mg/kg/2 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		EJPHAZ 494,213,2004
intraperitoneal
rat 		lowest published toxic dose: 560 mg/kg/28 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes 		BJMRDK 38,1043,2005
intraperitoneal
rat 		: 45 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		EJPHAZ 534,202,2006
intraperitoneal
rat 		lowest published toxic dose: 10,000 mg/kg/5 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Metabolism (intermediary): Other 		NRTXDN 28,161,2007
intravenous
rat 		lowest published toxic dose: 1,200 units/kg/6 week- intermittent Cardiac: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		BJMRDK 35,1379,2002
intravenous
rat 		lowest published toxic dose: 1,200 units/kg/6 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport 		TXCYAC 209,39,2005
oral
mouse 		lowest published toxic dose: 320 mg/kg/2 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Lipids including transport 		JOETD7 97,477,2005
oral
mouse 		lowest published toxic dose: 800 mg/kg/5 day- intermittent Behavioral: Alteration of classical conditioning JOETD7 97,477,2005
oral
mouse 		lowest published toxic dose: 3,500 mg/kg/10 week- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of operant conditioning

Immunological Including Allergic: Increase in cellular immune response 		ACPSI* 24,230,2003
oral
mouse 		lowest published toxic dose: 4,200 mg/kg/12 week- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of operant conditioning

Immunological Including Allergic: Increase in cellular immune response 		ACPSI* 24,230,2003
oral
mouse 		lowest published toxic dose: 350 units/kg/10 week- intermittent Cardiac: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		INHTE5 15,513,2003
oral
rat 		lowest published toxic dose: 39.7 gm/kg/13 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects FCTOD7 39,799,2001
oral
rat 		lowest published toxic dose: 39.7 gm/kg/13 week- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Changes in: Ca

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		FCTOD7 39,799,2001
oral
rat 		lowest published toxic dose: 1,500 mg/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) 		FCTOD7 42,1563,2004
oral
rat 		lowest published toxic dose: 2,400 mg/kg/6 week- intermittent Cardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXCYAC 202,227,2004
oral
rat 		lowest published toxic dose: 9.24 units/kg/4 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		TOXID9 1,48,2001
oral
rat 		: 500 mg/kg/5 day- intermittent Vascular: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		ACPSI* 25,1633,2004
oral
rat 		: 2,016 mg/kg/4 week- continuous Biochemical: Metabolism (intermediary): Lipids including transport BPBLEO 27,338,2004
oral
rat 		: 6,048 mg/kg/12 week- continuous Eye: Other eye effects BPBLEO 27,338,2004
oral
rat 		lowest published toxic dose: 1,000 mg/kg/8 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes 		TXCYAC 218,237,2006
oral
rat 		lowest published toxic dose: 10,500 mg/kg/21 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXCYAC 219,197,2006
oral
rat 		lowest published toxic dose: 2,700 mg/kg/45 day- intermittent Cardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXCYAC 224,128,2006
oral
rat 		lowest published toxic dose: 1,500 mg/kg/30 day- intermittent Endocrine: Change in LH

Endocrine: Change in gonadotropins

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		TXCYAC 232,170,2007
oral
rat 		lowest published toxic dose: 2,500 mg/kg/20 day- intermittent Biochemical: Metabolism (intermediary): Other NRTXDN 27,1024,2006
oral
rat 		lowest published toxic dose: 150 mg/kg/30 day- intermittent Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		TXCYAC 241,99,2007
oral
rat 		lowest published toxic dose: 1,400 mg/kg/2 week- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		IRJPH* 6,63,2007
oral
rat 		lowest published toxic dose: 1,181.1 mg/kg/31 week- intermittent Tumorigenic: Protects against induction of experimental tumors JTPAE7 18,53,2005
oral
rat 		lowest published toxic dose: 2,100 mg/kg/2 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport 		SIMEJ* 46,78,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ARPTDI 43,97,2003
TOXICOLOGY REVIEW
IJTOFN 21,51,2002
TOXICOLOGY REVIEW
TPHSDY 23,426,2002
TOXICOLOGY REVIEW
APHRER 39,2073,2005
TOXICOLOGY REVIEW
PHTOEH 93,105,2003
TOXICOLOGY REVIEW
ENTOX* -,449,2005
TOXICOLOGY REVIEW
FEREAC 73,9214,2008
TOXICOLOGY REVIEW
FEREAC 73,9214,2008
TOXICOLOGY REVIEW
FEREAC 73,9214,2008
TOXICOLOGY REVIEW
FEREAC 73,9214,2008
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5582;
Number of Industries 4;
Total Number of Facilities 279;
Number of Occupations 8;
Total Number of Employees Exposed 6,957;
Total Number of Female Employees Exposed 3,599


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HTOPA*
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
IRJPH*
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SIMEJ*
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as antioxidant

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

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