RTECS:DJ1892000 The Registry of Toxic Effects of Chemical Substances

Benzophenone, 2,2',4,4' - tetrahydroxy -

RTECS #: DJ1892000

CAS #: 131-55-5

UPDATE: February 2009 MW: 246.23 MF: C₁₃H₁₀O₅

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

MUTATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2,2',4,4' - Tetrahydroxy - benzophenone

2,4,2',4' - Tetrahydroxybenzophenone

Benzophenone - 2

Bis (2,4 - dihydroxyphenyl) methanone

Methanone, bis (2,4 - dihydroxyphenyl) - (9CI)

Uvinul D - 50

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
rabbit 100 mg moderate JACTDZ 2(5),35,1983

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis mouse lymphocyte 200 痢/plate JACTDZ 2(5),35,1983
mutation in microorganisms Salmonella typhimurium 100 痢/plate (-enzymatic activation step) FCTOD7 20,427,1982
sister chromatid exchange mouse lymphocyte 200 痢/plate JACTDZ 2(5),35,1983

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lethal dose (50 percent kill): 1,220 mg/kg N/R JACTDZ 2(5),35,1983

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
multiple
non-mammalian species lowest published toxic concentration: 1.2 gm/m³/15 day- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 225,255,2007
multiple
non-mammalian species lowest published toxic concentration: 1.2 gm/m³/15 day- continuous Reproductive: Maternal effects: Oogenesis TXAPA9 225,255,2007
oral
rat lowest published toxic dose: 15,540 mg/kg/12 week- intermittent Endocrine: Estrogenic

Musculoskeletal: Other changes

Related to Chronic Data: Changes in uterine weight TXCYAC 205,103,2004
oral
rat lowest published toxic dose: 750 mg/kg/5 day- intermittent Endocrine: Estrogenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight TXCYAC 205,87,2004
oral
rat lowest published toxic dose: 12,852 mg/kg/12 week- intermittent Endocrine: Change in LH

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Lipids including transport TXCYAC 213,13,2005
oral
rat lowest published toxic dose: 500 mg/kg/5 day- intermittent Endocrine: Estrogenic

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Changes in uterine weight ARTODN 80,656,2006
oral
rat lowest published toxic dose: 1,665 mg/kg/5 day- intermittent Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport ARTODN 80,656,2006
oral
rat lowest published toxic dose: 5,000 mg/kg/5 day- intermittent Liver: Other changes

Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight ARTODN 80,656,2006
oral
rat lowest published toxic dose: 500 mg/kg/5 day- intermittent Related to Chronic Data: Changes in uterine weight TXCYAC 245,11,2008
subcutaneous
rat lowest published toxic dose: 600 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight TOLED5 142,119,2003

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7078;
Number of Industries 1;
Total Number of Facilities 9;
Number of Occupations 2;
Total Number of Employees Exposed 869;
Total Number of Female Employees Exposed 617

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a pigment stabilizer in cosmetic preparations with fragrances

RTECS Compound Description:
Mutagen
Primary Irritant

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SYNONYMS:
2,2',4,4' - Tetrahydroxy - benzophenone 2,4,2',4' - Tetrahydroxybenzophenone Benzophenone - 2	Bis (2,4 - dihydroxyphenyl) methanone Methanone, bis (2,4 - dihydroxyphenyl) - (9CI) Uvinul D - 50

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye rabbit	100 mg	moderate	JACTDZ 2(5),35,1983

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	mouse lymphocyte	200 痢/plate	JACTDZ 2(5),35,1983
mutation in microorganisms	Salmonella typhimurium	100 痢/plate (-enzymatic activation step)	FCTOD7 20,427,1982
sister chromatid exchange	mouse lymphocyte	200 痢/plate	JACTDZ 2(5),35,1983

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lethal dose (50 percent kill): 1,220 mg/kg	N/R	JACTDZ 2(5),35,1983

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
multiple non-mammalian species	lowest published toxic concentration: 1.2 gm/m³/15 day- continuous	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXAPA9 225,255,2007
multiple non-mammalian species	lowest published toxic concentration: 1.2 gm/m³/15 day- continuous	Reproductive: Maternal effects: Oogenesis	TXAPA9 225,255,2007
oral rat	lowest published toxic dose: 15,540 mg/kg/12 week- intermittent	Endocrine: Estrogenic Musculoskeletal: Other changes Related to Chronic Data: Changes in uterine weight	TXCYAC 205,103,2004
oral rat	lowest published toxic dose: 750 mg/kg/5 day- intermittent	Endocrine: Estrogenic Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in uterine weight	TXCYAC 205,87,2004
oral rat	lowest published toxic dose: 12,852 mg/kg/12 week- intermittent	Endocrine: Change in LH Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Lipids including transport	TXCYAC 213,13,2005
oral rat	lowest published toxic dose: 500 mg/kg/5 day- intermittent	Endocrine: Estrogenic Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data: Changes in uterine weight	ARTODN 80,656,2006
oral rat	lowest published toxic dose: 1,665 mg/kg/5 day- intermittent	Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport	ARTODN 80,656,2006
oral rat	lowest published toxic dose: 5,000 mg/kg/5 day- intermittent	Liver: Other changes Endocrine: Estrogenic Related to Chronic Data: Changes in uterine weight	ARTODN 80,656,2006
oral rat	lowest published toxic dose: 500 mg/kg/5 day- intermittent	Related to Chronic Data: Changes in uterine weight	TXCYAC 245,11,2008
subcutaneous rat	lowest published toxic dose: 600 mg/kg/3 day- intermittent	Related to Chronic Data: Changes in uterine weight	TOLED5 142,119,2003

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X7078; Number of Industries 1; Total Number of Facilities 9; Number of Occupations 2; Total Number of Employees Exposed 869; Total Number of Female Employees Exposed 617

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN	REFERENCE
ARTODN	Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
FCTOD7	Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
JACTDZ	Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9	Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC	Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-