The Registry of Toxic Effects of Chemical Substances

Benzophenone

RTECS #: DI9950000

CAS #: 119-61-9

UPDATE: August 2008 MW: 182.23 MF: C13H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Benzene, benzoyl -
  2. Benzoylbenzene
  3. Diphenyl ketone
  4. Diphenylmethanone
  1. Ketone, diphenyl
  2. Phenyl ketone
  3. alpha - Oxodiphenylmethane
  4. alpha - Oxoditane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage human Ascites tumor 10 mg/L/2 hour FCTOD7 42,1323,2004


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 4,200 mg/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTPTR* TER-98005
oral
rat 		lowest published toxic dose: 1,400 mg/kg (6-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system NTPTR* TER-98005
oral
rabbit 		lowest published toxic dose: 600 mg/kg (6-29 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Abortion 		NTPTR* TER-99001
oral
rabbit 		lowest published toxic dose: 1,080 mg/kg (6-29 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTPTR* TER-99001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 727 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes 		EJTXAZ 9,99,1976
oral
mouse 		lethal dose (50 percent kill): 2,895 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes 		EJTXAZ 9,99,1976
oral
rat 		lethal dose (50 percent kill): >10 gm/kg N/R FCTXAV 11,873,1973
skin
rabbit 		lethal dose (50 percent kill): 3,535 mg/kg N/R FCTXAV 11,873,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic dose: 75 mg/kg/15 day- intermittent Liver: Other changes

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) 		BECTA6 50,282,1993
intraperitoneal
rat 		lowest published toxic dose: 150 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXAPA9 193,66,2003
intraperitoneal
rat 		lowest published toxic dose: 900 mg/kg/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight 		TXAPA9 203,9,2005
oral
mouse 		lowest published toxic dose: 109 gm/kg/13 week- continuous Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 14,221,1994
oral
mouse 		lowest published toxic dose: 19,600 mg/kg/14 week- continuous Liver: Other changes

Liver: Changes in liver weight 		NTPTR* NIH-00-3943
oral
mouse 		: 38,850 mg/kg/37 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-533
oral
mouse 		: 21,070 mg/kg/86 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-533
oral
mouse 		: 58,800 mg/kg/105 week- intermittent Liver: Tumors NTPTR* NTP-TR-533
oral
mouse 		: 51,450 mg/kg/105 week- intermittent Liver: Tumors

Blood: Tumors 		NTPTR* NTP-TR-533
oral
mouse 		: 25,725 mg/kg/105 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen 		NTPTR* NTP-TR-533
oral
mouse 		: 29,400 mg/kg/105 week- intermittent Liver: Other changes

Blood: Changes in spleen 		NTPTR* NTP-TR-533
oral
mouse 		: 110,250 mg/kg/105 week- intermittent Eye: Other eye effects NTPTR* NTP-TR-533
oral
mouse 		lowest published toxic dose: 29,400 mg/kg/105 week- continuous Liver: Tumors

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen 		FCTOD7 45,843,2007
oral
mouse 		lowest published toxic dose: 58,800 mg/kg/105 week- continuous Liver: Hepatitis (hepatocellular necrosis), zonal FCTOD7 45,843,2007
oral
mouse 		lowest published toxic dose: 117,600 mg/kg/105 week- continuous Olfaction: Other olfaction effects

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		FCTOD7 45,843,2007
oral
mouse 		lowest published toxic dose: 25,725 mg/kg/105 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen 		FCTOD7 45,843,2007
oral
mouse 		lowest published toxic dose: 110,250 mg/kg/105 week- continuous Olfaction: Other olfaction effects FCTOD7 45,843,2007
oral
rat 		lowest published toxic dose: 14 gm/kg/28 day- continuous Blood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count 		FCTOD7 29,741,1971
oral
rat 		lowest published toxic dose: 91 gm/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 14,221,1994
oral
rat 		lowest published toxic dose: 7,350 mg/kg/14 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		NTPTR* NIH-00-3943
oral
rat 		lowest published toxic dose: 1,200 mg/kg/3 day- intermittent Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight 		ARTODN 76,727,2002
oral
rat 		lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Behavioral: Sleep

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		NTPTR* TER-98005
oral
rat 		lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Skin and Appendages: Other: Hair NTPTR* TER-98005
oral
rat 		lowest published toxic dose: 400 mg/kg/4 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* TER-98005
oral
rat 		lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Behavioral: Fluid intake NTPTR* TER-98005
oral
rat 		: 44,100 mg/kg/105 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-533
oral
rat 		: 26,040 mg/kg/62 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-533
oral
rat 		: 36,120 mg/kg/86 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-533
oral
rat 		: 2,100 mg/kg/10 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-533
oral
rat 		: 29,400 mg/kg/70 week- intermittent Behavioral: Food intake (animal) NTPTR* NTP-TR-533
oral
rat 		: 11,025 mg/kg/105 week- intermittent Kidney, Ureter, and Bladder: Bladder tumors

Kidney, Ureter, and Bladder: Kidney tumors

Blood: Leukemia 		NTPTR* NTP-TR-533
oral
rat 		: 11,025 mg/kg/105 week- intermittent Liver: Other changes NTPTR* NTP-TR-533
oral
rat 		: 11,025 mg/kg/105 week- intermittent Kidney, Ureter, and Bladder: Other changes

Liver: Change in gall bladder structure or function

Liver: Other changes 		NTPTR* NTP-TR-533
oral
rat 		: 22,050 mg/kg/105 week- intermittent Blood: Leukemia NTPTR* NTP-TR-533
oral
rat 		: 47,775 mg/kg/105 week- intermittent Blood: Tumors NTPTR* NTP-TR-533
oral
rat 		lowest published toxic dose: 22,050 mg/kg/105 week- continuous Kidney, Ureter, and Bladder: Kidney tumors FCTOD7 45,843,2007
oral
rat 		lowest published toxic dose: 11,035 mg/kg/105 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Leukemia 		FCTOD7 45,843,2007
oral
rat 		lowest published toxic dose: 44,100 mg/kg/105 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field FCTOD7 45,843,2007
oral
rat 		lowest published toxic dose: 22,050 mg/kg/105 week- continuous Kidney, Ureter, and Bladder: Kidney tumors

Blood: Leukemia 		FCTOD7 45,843,2007
oral
rat 		lowest published toxic dose: 11,035 mg/kg/105 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		FCTOD7 45,843,2007
oral
rabbit 		lowest published toxic dose: 600 mg/kg/24 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* TER-99001
oral
rabbit 		lowest published toxic dose: 400 mg/kg/16 day- intermittent Behavioral: Food intake (animal) NTPTR* TER-99001
oral
rabbit 		lowest published toxic dose: 450 mg/kg/10 day- intermittent Behavioral: Food intake (animal) NTPTR* TER-99001
oral
rabbit 		lowest published toxic dose: 720 mg/kg/16 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* TER-99001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
REPTED 25,192,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83170;
Number of Industries 8;
Total Number of Facilities 1,495;
Number of Occupations 11;
Total Number of Employees Exposed 6,944
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83170;
Number of Industries 27;
Total Number of Facilities 1,809;
Number of Occupations 50;
Total Number of Employees Exposed 41,516;
Total Number of Female Employees Exposed 18,162


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in UV curing of inks and coatings and as intermediate, also used in fragrances
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in UV curing of inks and coatings and as intermediate, also used in fragrances

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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