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Benzoic acid, 2 - hydroxy - , 2 - carboxyphenyl ester

RTECS #: DH2080000

CAS #: 552-94-3

UPDATE: August 2008 MW: 258.24 MF: C14H10O5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Diacesal
  2. Diplosal
  3. Disalcid
  4. Disalicylic acid
  5. Disalyl
  6. NSC - 49171
  7. Nobacid
  8. SAA
  9. Salical
  10. Salicylic acid, bimolecular ester
  11. Salicyloylsalicylic acid
  1. Salicylsalicylic acid
  2. Salina
  3. Saloxium
  4. Salsalate
  5. Salysal
  6. Sasapirin
  7. Sasapyrin
  8. Sasapyrine
  9. Sasapyrinum
  10. o - Salicylsalicylic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 665 mg/kg (17 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other effects to embryo or fetus

Reproductive: Other developmental abnormalities 		APTOA6 29,250,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
man 		lowest published toxic dose: 2,229 mg/kg/2 year- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) AIMEAS 107,116,1987
subcutaneous
mouse 		lethal dose (50 percent kill): 1,020 mg/kg N/R YAKUD5 22,1101,1980
unreported route
dog 		lowest published lethal dose: 1,200 mg/kg N/R HBAMAK 4,1289,1935
unreported route
guinea pig 		lowest published lethal dose: 2 gm/kg N/R HBAMAK 4,1289,1935


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
APHRER 38,1159,2004
TOXICOLOGY REVIEW
AJEMEN 22,404,2004
TOXICOLOGY REVIEW
APHRER 40,1924,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80509;
Number of Industries 2;
Total Number of Facilities 105;
Number of Occupations 7;
Total Number of Employees Exposed 3,179
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80509;
Number of Industries 1;
Total Number of Facilities 34;
Number of Occupations 2;
Total Number of Employees Exposed 629;
Total Number of Female Employees Exposed 291


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

FDA-over the counter drug

RTECS Compound Description:
   Reproductive Effector
   Human Data

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