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Benzoic acid, 3,5 - diacetamido - 2,4,6 - triiodo - , monosodium salt

RTECS #: DG6125000

CAS #: 737-31-5

UPDATE: May 2008 MW: 635.90 MF: C11H8I3N2O4•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 3,5 - Diacetamido - 2,4,6 - triiodobenzoic acid, sodium salt
  2. 3,5 - Diacetylamino - 2,4,6 - trijodbenzosaeure natrium (German)
  3. Diatrizoate sodium salt
  4. Hypaque
  5. Hypaque 50
  6. Hypaque sodium
  7. Sodium amidotrizoate
  1. Sodium 3,5 - diacetamido - 2,4,6 - triiodobenzoate
  2. Sodium diacetyldiaminetriiodobenzoate
  3. Sodium diatrizoate
  4. Triombrin
  5. Triombrine
  6. WIN 8308 - 3


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 2,000 ppm RADLAX 129,199,1978
micronucleus test human lymphocyte 40 mg/L RADLAX 129,199,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lethal dose (50 percent kill): 20,349 mg/kg N/R JPETAB 117,307,1956
intraperitoneal
mouse 		lethal dose (50 percent kill): >5 gm/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		TOVEFN (3),46,1994
intraperitoneal
rat 		lethal dose (50 percent kill): >5 gm/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		TOVEFN (3),46,1994
intraperitoneal
rat 		lowest published toxic dose: 600 µg( intermittent)/kg Endocrine: Evidence of thyroid hypofunction FATOAO 45,96,1982
intravenous
cat 		lethal dose (50 percent kill): 11,300 mg/kg N/R CLDND*
intravenous
dog 		lethal dose (50 percent kill): 13,200 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting 		JPETAB 116,394,1956
intravenous
mouse 		lethal dose (50 percent kill): 14 gm/kg N/R JPETAB 116,394,1956
intravenous
rat 		lethal dose (50 percent kill): 11,400 mg/kg N/R JPETAB 116,394,1956
intravenous
rabbit 		lethal dose (50 percent kill): 12,200 mg/kg N/R JPETAB 116,394,1956
oral
mouse 		lethal dose (50 percent kill): >7 gm/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		TOVEFN (3),46,1994
oral
rat 		lethal dose (50 percent kill): >7 gm/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis 		TOVEFN (3),46,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
LANCAO 359,1037,2002
TOXICOLOGY REVIEW
TOLED5 144,383,2003
TOXICOLOGY REVIEW
FCLPH* 19,263,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0840;
Number of Industries 2;
Total Number of Facilities 305;
Number of Occupations 2;
Total Number of Employees Exposed 2,285
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0840;
Number of Industries 1;
Total Number of Facilities 941;
Number of Occupations 8;
Total Number of Employees Exposed 22,494;
Total Number of Female Employees Exposed 15,852


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
RADLAX Radiology. (Radiological Soc. of North America, 20th & Northampton Sts., Easton, PA 18042) V.1- 1923-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown

Used as a diagnostic aid (radiopaque medium)

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Human Data

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