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Benzoic acid, 3 - amino - 4 - propoxy - , 2 - (diethylamino) ethyl ester, hydrochloride

RTECS #: DG3065000

CAS #: 5875-06-9

UPDATE: April 1999 MW: 330.90 MF: C16H26N2O3•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. REFERENCES:

SYNONYMS:

  1. 2 - Diethylaminoethyl 3 - amino - 4 - propoxybenzoate hydrochloride
  2. 3 - Amino - 4 - propoxybenzoic acid 2 - (diethylamino) ethyl ester hydrochloride
  3. Alcaine
  4. Chibro - Heracaine
  5. Keracaine
  1. Ophthain
  2. Ophthaine hydrochloride
  3. Ophthetic
  4. Proparacaine hydrochloride
  5. beta - (Diethylamino) ethyl 3 - amino - 4 - n - propoxybenzoate hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 3,371 µg/kg Behavioral: Convulsions or effect on seizure threshold

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes 		JPETAB 123,269,1958
subcutaneous
mouse 		lethal dose (50 percent kill): 64 mg/kg N/R APFRAD 40,133,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3223;
Number of Industries 2;
Total Number of Facilities 412;
Number of Occupations 7;
Total Number of Employees Exposed 3,442;
Total Number of Female Employees Exposed 2,127


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-

RTECS Compound Description:
   Drug

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