RTECS:DF2368050 The Registry of Toxic Effects of Chemical Substances

2H - 1,4 - Benzodiazepin - 2 - one, 1,3 - dihydro - 7 - chloro - 1 - (2 - (diethylamino) ethyl) - 5 - (o - fluorophenyl) -

RTECS #: DF2368050

CAS #: 17617-23-1

UPDATE: December 1998 MW: 387.92 MF: C₂₁H₂₃ClFN₃O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

2H - 1,4 - Benzodiazepin - 2 - one, 7 - chloro - 1 - (2 - (diethylamino) ethyl) - 5 - (2 - fluorophenyl) - 1,3 - dihydro -

7 - Chloro - 1 - (2 - (diethylamino) ethyl) - 5 - (2 - fluorophenyl) - 1H - 1,4 - benzodiazepin - 2 (3H) - one

Flurazepam

Ro - 5 - 6901/3

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
mouse lowest published toxic dose: 504 mg/kg (1-21 day pregnant) Reproductive: Effects on newborn: Behavioral PLRCAT 9,325,1977

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 540 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory stimulation OYYAA2 14,637,1977
intraperitoneal
rat lethal dose (50 percent kill): 600 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory stimulation OYYAA2 14,637,1977
intravenous
mouse lethal dose (50 percent kill): 59,100 痢/kg N/R IYKEDH 6,530,1975
intravenous
rat lethal dose (50 percent kill): 38,700 痢/kg N/R IYKEDH 6,530,1975
oral
cat lowest published lethal dose: 250 mg/kg N/R DRFUD4 9,152,1984
oral
human lowest published toxic dose: 380 痢/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes AJMEAZ 73,239,1982
oral
mouse lethal dose (50 percent kill): 500 mg/kg N/R THERAP 26,439,1971
oral
rat lethal dose (50 percent kill): 980 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory stimulation OYYAA2 14,637,1977
subcutaneous
mouse lethal dose (50 percent kill): 3,844 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory stimulation OYYAA2 14,637,1977
subcutaneous
rat lethal dose (50 percent kill): >3,844 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory stimulation OYYAA2 14,637,1977

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 12 gm/kg/30 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases OYYAA2 14,637,1977

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6124;
Number of Industries 1;
Total Number of Facilities 25;
Number of Occupations 2;
Total Number of Employees Exposed 3,703;
Total Number of Female Employees Exposed 3,592

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969-
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946-

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

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SYNONYMS:
2H - 1,4 - Benzodiazepin - 2 - one, 7 - chloro - 1 - (2 - (diethylamino) ethyl) - 5 - (2 - fluorophenyl) - 1,3 - dihydro - 7 - Chloro - 1 - (2 - (diethylamino) ethyl) - 5 - (2 - fluorophenyl) - 1H - 1,4 - benzodiazepin - 2 (3H) - one	Flurazepam Ro - 5 - 6901/3

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral mouse	lowest published toxic dose: 504 mg/kg (1-21 day pregnant)	Reproductive: Effects on newborn: Behavioral	PLRCAT 9,325,1977

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 540 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Respiratory stimulation	OYYAA2 14,637,1977
intraperitoneal rat	lethal dose (50 percent kill): 600 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Respiratory stimulation	OYYAA2 14,637,1977
intravenous mouse	lethal dose (50 percent kill): 59,100 痢/kg	N/R	IYKEDH 6,530,1975
intravenous rat	lethal dose (50 percent kill): 38,700 痢/kg	N/R	IYKEDH 6,530,1975
oral cat	lowest published lethal dose: 250 mg/kg	N/R	DRFUD4 9,152,1984
oral human	lowest published toxic dose: 380 痢/kg	Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes	AJMEAZ 73,239,1982
oral mouse	lethal dose (50 percent kill): 500 mg/kg	N/R	THERAP 26,439,1971
oral rat	lethal dose (50 percent kill): 980 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Respiratory stimulation	OYYAA2 14,637,1977
subcutaneous mouse	lethal dose (50 percent kill): 3,844 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Respiratory stimulation	OYYAA2 14,637,1977
subcutaneous rat	lethal dose (50 percent kill): >3,844 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Lung, Thorax, or Respiration: Respiratory stimulation	OYYAA2 14,637,1977

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 12 gm/kg/30 day- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	OYYAA2 14,637,1977

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X6124; Number of Industries 1; Total Number of Facilities 25; Number of Occupations 2; Total Number of Employees Exposed 3,703; Total Number of Female Employees Exposed 3,592

REFERENCES:
CODEN	REFERENCE
AJMEAZ	American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
DRFUD4	Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76-
IYKEDH	Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
OYYAA2	Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PLRCAT	Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969-
THERAP	Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946-