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2H - 1,4 - Benzodiazepin - 2 - one, 1,3 - dihydro - 7 - chloro - 1 - (cyclopropylmethyl) - 5 - phenyl -

RTECS #: DF2368000

CAS #: 2955-38-6

UPDATE: May 2009 MW: 324.83 MF: C19H17ClN2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. 7 - Chloro - 1 - (cyclopropylmethyl) - 1,3 - dihydro - 5 - phenyl - 2H - 1,4 - benzodiazepin - 2 - one
  2. 7 - Chloro - 1 - cyclopropylmethyl - 5 - phenyl - 1H - 1,4 - benzodiazepin - 2 (3H) - one
  3. Demetrin
  4. K - 373
  1. Lysanxia
  2. Prazepam
  3. Verstran
  4. W 4020


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 624 mg/kg (26 day prior to copulation) Reproductive: Maternal effects: Parturition RCOCB8 11,155,1975
oral
mouse 		lowest published toxic dose: 1,656 mg/kg (5 day male/3 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		PLRCAT 9,187,1977
oral
mouse 		lowest published toxic dose: 800 mg/kg (5 day male/15 day prior to copulation) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) RCOCB8 13,601,1976
oral
mouse 		lowest published toxic dose: 504 mg/kg (1-21 day pregnant) Reproductive: Effects on newborn: Behavioral PLRCAT 9,325,1977
oral
rat 		lowest published toxic dose: 21 gm/kg (14 day prior to copulation/1-7 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) OYYAA2 15,813,1978
oral
rat 		lowest published toxic dose: 250 mg/kg (8-17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) OYYAA2 15,797,1978
oral
rat 		lowest published toxic dose: 2,500 mg/kg (8-17 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on newborn: Stillbirth 		OYYAA2 15,797,1978
oral
rat 		lowest published toxic dose: 10 gm/kg (8-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Homeostasis 		OYYAA2 15,797,1978
oral
rat 		lowest published toxic dose: 135 mg/kg (17-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Behavioral OYYAA2 17,833,1979
oral
rabbit 		lowest published toxic dose: 650 mg/kg (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system OYYAA2 17,673,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 14 gm/kg/80 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease 		TXAPA9 57,39,1981
oral
rat 		lowest published toxic dose: 5,284 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors 		TXAPA9 57,39,1981
oral
rat 		toxic dose : 55 gm/kg/2 year- continuous Tumorigenic: Active as anti-cancer agent

Skin and Appendages: Tumors 		TXAPA9 57,39,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,020 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		OYYAA2 15,241,1978
intraperitoneal
rat 		lethal dose (50 percent kill): >2 gm/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		OYYAA2 15,241,1978
oral
dog 		lethal dose (50 percent kill): >4 gm/kg Behavioral: Food intake (animal)

Behavioral: Ataxia

Nutritional and Gross Metabolic: Body temperature decrease 		OYYAA2 15,759,1978
oral
mouse 		lethal dose (50 percent kill): 2,300 mg/kg N/R JKXXAF #79-92631
oral
rat 		lethal dose (50 percent kill): >4 gm/kg Eye: Lacrimation

Behavioral: Ataxia

Nutritional and Gross Metabolic: Body temperature decrease 		OYYAA2 15,241,1978
subcutaneous
mouse 		lethal dose (50 percent kill): >2 gm/kg Behavioral: Somnolence (general depressed activity) OYYAA2 15,241,1978
subcutaneous
rat 		lethal dose (50 percent kill): >2 gm/kg Behavioral: Somnolence (general depressed activity) OYYAA2 15,241,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 1,200 mg/kg/30 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Changes in prostate weight 		OYYAA2 15,759,1978
oral
rat 		lowest published toxic dose: 35 gm/kg/35 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Changes in testicular weight 		OYYAA2 15,247,1978
oral
rat 		lowest published toxic dose: 930 mg/kg/31 week- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Changes in prostate weight 		OYYAA2 15,777,1978
oral
rat 		lowest published toxic dose: 40,500 mg/kg/27 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		OYYAA2 15,269,1978


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 66,143,1996
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 66,143,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 66,143,1996
TOXICOLOGY REVIEW
HUTOX* -,281,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5481;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 1;
Total Number of Employees Exposed 94;
Total Number of Female Employees Exposed 62


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969-
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a minor tranquilizer and muscle relaxant

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Reproductive Effector

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