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2 - H - 1,4 - Benzodiazepin - 2 - one, 5 - (o - chlorophenyl) - 1,3 - dihydro - 7 - nitro -

RTECS #: DF2100000

CAS #: 1622-61-3

UPDATE: May 2009 MW: 315.73 MF: C15H10ClN3O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,3 - Dihydro - 7 - nitro - 5 - (2 - chlorophenyl) - 2H - 1,4.benzodiazepin - 2 - one
  2. 5 - (2 - Chlorophenyl) - 1,3 - dihydro - 7 - nitro - 2H - 1,4 - benzodiazepin - 2 - one
  3. 5 - (o - Chlorophenyl) - 1,3 - dihydro - 7 - nitro - 2H - 1,4 - benzodiazepin - 2 - one
  4. 5 - (o - Chlorophenyl) - 7 - nitro - 1H - 1,4 - benzodiazepin - 2 (3H) - one
  5. Antelepsin
  6. Antilepsin
  7. Clonazepam
  1. Clonopin
  2. Iktorivil
  3. Klonopin
  4. Landsen
  5. Rivotril
  6. Ro 5 - 4023


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 3,300 µg/kg (6-16 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TXAPA9 40,365,1977
oral
rabbit 		lowest published toxic dose: 24 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		YACHDS 5,2457,1977
subcutaneous
mouse 		lowest published toxic dose: 8 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system 		DGDFA5 22,61,1980
subcutaneous
rat 		lowest published toxic dose: 1,750 µg/kg (14-20 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic LIFSAK 44,493,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 13,300 mg/kg N/R IYKEDH 11,811,1980
intraperitoneal
mouse 		lowest published toxic dose: 0.2 mg/kg Behavioral: Anticonvulsant EURNE* 14,77,2003
intraperitoneal
mouse 		lowest published toxic dose: 11.3 mg/kg Behavioral: Change in psychophysiological tests EURNE* 14,77,2003
intraperitoneal
mouse 		lowest published toxic dose: 0.11 mg/kg Brain and Coverings: Other degenerative changes JPETAB 316,1378,2006
intraperitoneal
mouse 		lowest published toxic dose: 0.8 mg/kg Behavioral: Convulsions or effect on seizure threshold JPETAB 316,1378,2006
intraperitoneal
mouse 		lowest published toxic dose: 0.28 mg/kg Behavioral: Anticonvulsant

Behavioral: Ataxia 		PHREP* 57,458,2005
intraperitoneal
rat 		lethal dose (50 percent kill): 14,200 mg/kg N/R IYKEDH 11,811,1980
intraperitoneal
rat 		lowest published toxic dose: 1 mg/kg Brain and Coverings: Recordings from specific areas of CNS EJPHAZ 466,255,2003
intraperitoneal
rat 		lowest published toxic dose: 0.5 mg/kg Behavioral: Anticonvulsant EURNE* 12,225,2002
intraperitoneal
rat 		lowest published toxic dose: 0.25 mg/kg Endocrine: Hyperglycemia BJMRDK 34,57,2001
intravenous
man 		lowest published toxic dose: 0.143 mg/kg Behavioral: Somnolence (general depressed activity)

Endocrine: Hyperglycemia 		BMCCP* 4,3,2004
intravenous
mouse 		lethal dose (50 percent kill): >18 mg/kg N/R IYKEDH 11,811,1980
oral
man 		lowest published toxic dose: 21 mg/kg/26 week- intermittent Peripheral Nerve and Sensation: Fasciculations PGMJAO 63,311,1987
oral
man 		lowest published toxic dose: 1,329 µg/kg/31 day- intermittent Liver: Liver function tests impaired AJGAAR 83,576,1988
oral
monkey 		lowest published toxic dose: 0.5 mg/kg Behavioral: Antianxiety JPETAB 303,777,2002
oral
mouse 		lethal dose (50 percent kill): 2 gm/kg N/R PJPPAA 35,77,1983
oral
mouse 		lowest published toxic dose: 0.1 mg/kg N/R JOETD7 76,145,2001
oral
mouse 		lowest published toxic dose: 0.1 mg/kg Behavioral: Anticonvulsant JOETD7 76,145,2001
oral
rat 		lethal dose (50 percent kill): >15 gm/kg N/R NIIRDN 6,235,1982
oral
rat 		lowest published toxic dose: 0.2 mg/kg Endocrine: Change in GH PHTOEH 71,75,1992
oral
rat 		lowest published toxic dose: 1 mg/kg Endocrine: Change in LH PHTOEH 71,75,1992
subcutaneous
mouse 		lethal dose (50 percent kill): >10 gm/kg N/R NIIRDN 6,235,1982
subcutaneous
rat 		lethal dose (50 percent kill): >10 gm/kg N/R NIIRDN 6,235,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
human 		lowest published toxic dose: 15.6 mg/kg/78 week- intermittent Behavioral: Antipsychotic

Behavioral: Change in psychophysiological tests 		EURNE* 13,129,2003
oral
human 		lowest published toxic dose: 0.3 mg/kg/3 week- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Gastrointestinal: Nausea or vomiting 		APHRER 38,1395,2004
oral
rat 		lowest published toxic dose: 7,280 mg/kg/26 week- intermittent Brain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in thyroid weight 		YACHDS 4,1441,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TPHSDY 24,542,2003
TOXICOLOGY REVIEW
AJEMEN 22,404,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5401;
Number of Industries 1;
Total Number of Facilities 46;
Number of Occupations 3;
Total Number of Employees Exposed 998;
Total Number of Female Employees Exposed 546


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Body fluid assay; Host-mediated assay


REFERENCES:

CODEN
REFERENCE
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AJGAAR American Journal of Gastroenterology. (American College of Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21- 1954-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
BMCCP*
DGDFA5 Development, Growth & Differentiation. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.11- 1969-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EURNE* European Neuropsychopharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Nov.1990-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
PHREP*
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information, see PJPAE3
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-

Used as an anticonvulsant

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 106955-87-7
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