RTECS:DD6625350 The Registry of Toxic Effects of Chemical Substances

Benzene, 1,1' - oxybis - , pentabromo deriv.

RTECS #: DD6625350

CAS #: 32534-81-9

UPDATE: August 2008 MW: 564.72 MF: C₁₂H₅Br₅O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Bromkal G1

DE60FTM

Pentabromodiphenyl ether

Pentabromodiphenyl ether (DE - 71)

Pentabromodiphenyl oxide

Planelon PB 501

Saytex 125

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
rabbit 500 無/24 hour mild NTIS OTS0522196
skin
rabbit 100 無/24 hour moderate NTIS OTS0522196

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lethal concentration : >200 gm/m³/1 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands NTIS OTS0540414
inhalation
rat lethal concentration (50 percent kill): 200 gm/m³/1 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea EVHPAZ 109,49,2001
oral
mouse lowest published toxic dose: 0.8 mg/kg Endocrine: Evidence of thyroid hypofunction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TXCYAC 86,49,1994
oral
rat lethal dose (50 percent kill): 5 gm/kg Behavioral: Tremor

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS OTS0522287
oral
rat lethal dose (50 percent kill): 7.4 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea EVHPAZ 109,49,2001
skin
rat lowest published lethal dose: 5,500 mg/kg Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair NTIS OTS0522196
skin
rabbit lethal dose : >2 gm/kg N/R NTIS OTS0540414
skin
rabbit lethal dose (50 percent kill): 2 gm/kg/24 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea EVHPAZ 109,49,2001

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
mammal (species unspecified) lowest published toxic dose: 790.6 mg/kg/2 week- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) VCVGK* -,315,1994
oral
mouse lowest published toxic dose: 14,000 mg/kg/14 day- intermittent Endocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TXCYAC 86,49,1994
oral
rat lowest published toxic dose: 39,040 mg/kg/122 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,315,1994
oral
rat lowest published toxic dose: 280 mg/kg/28 day- continuous Liver: Other changes

Liver: Changes in liver weight EVHPAZ 109,49,2001
oral
rat lowest published toxic dose: 420 mg/kg/14 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins TOXID9 90,160,2006

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
ENTOX* -,507,2005
TOXICOLOGY REVIEW
JTEHF8 69,21,2006

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as brominated lame retardants and a fire-extinguishing agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as brominated lame retardants and a fire-extinguishing agent

RTECS Compound Description:
Primary Irritant

ALT CAS #: 132405-96-0
ALT CAS #: 134206-43-2
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SYNONYMS:
Bromkal G1 DE60FTM Pentabromodiphenyl ether Pentabromodiphenyl ether (DE - 71)	Pentabromodiphenyl oxide Planelon PB 501 Saytex 125

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
skin rabbit	500 無/24 hour	mild	NTIS** OTS0522196
skin rabbit	100 無/24 hour	moderate	NTIS** OTS0522196

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lethal concentration : >200 gm/m³/1 hour	Eye: Lacrimation Lung, Thorax, or Respiration: Respiratory stimulation Gastrointestinal: Changes in structure or function of salivary glands	NTIS** OTS0540414
inhalation rat	lethal concentration (50 percent kill): 200 gm/m³/1 hour	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea	EVHPAZ 109,49,2001
oral mouse	lowest published toxic dose: 0.8 mg/kg	Endocrine: Evidence of thyroid hypofunction Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TXCYAC 86,49,1994
oral rat	lethal dose (50 percent kill): 5 gm/kg	Behavioral: Tremor Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0522287
oral rat	lethal dose (50 percent kill): 7.4 gm/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea	EVHPAZ 109,49,2001
skin rat	lowest published lethal dose: 5,500 mg/kg	Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea Skin and Appendages: Other: Hair	NTIS** OTS0522196
skin rabbit	lethal dose : >2 gm/kg	N/R	NTIS** OTS0540414
skin rabbit	lethal dose (50 percent kill): 2 gm/kg/24 hour	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea	EVHPAZ 109,49,2001

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral mammal (species unspecified)	lowest published toxic dose: 790.6 mg/kg/2 week- intermittent	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	VCVGK* -,315,1994
oral mouse	lowest published toxic dose: 14,000 mg/kg/14 day- intermittent	Endocrine: Changes in thymus weight Immunological Including Allergic: Decreased immune response Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TXCYAC 86,49,1994
oral rat	lowest published toxic dose: 39,040 mg/kg/122 day- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,315,1994
oral rat	lowest published toxic dose: 280 mg/kg/28 day- continuous	Liver: Other changes Liver: Changes in liver weight	EVHPAZ 109,49,2001
oral rat	lowest published toxic dose: 420 mg/kg/14 day- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Other proteins	TOXID9 90,160,2006

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		TOLED5 127,111,2002
TOXICOLOGY REVIEW		ENTOX* -,507,2005
TOXICOLOGY REVIEW		JTEHF8 69,21,2006

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
N/R	N/R	N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as brominated lame retardants and a fire-extinguishing agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ	EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
JTEHF8	Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9	Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC	Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.