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Benzenesulfonic acid, 5 - (2H - naphtho (1,2 - d) triazol - 2 - yl) - 2 - (2 - phenylethenyl) - , sodium salt

RTECS #: DB7180000

CAS #: 6416-68-8

UPDATE: January 1997 MW: 449.48 MF: C24H16N3O3S•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2 - Stilbenesulfonic acid, 4 - (2H - naphtho (1,2 - d) triazol - 2 - yl) - , sodium salt
  2. 2H - Naphtho (1,2 - d) triazole, 2 - (4 - (2 - phenylethenyl) - 3 - sulfophenyl) - , sodium salt
  3. C.I. 40645
  4. C.I. Fluorescent Brightener 46
  5. C.I. Fluorescent Brightening Agent 46, sodium salt (8CI)
  1. Fluorescent brightener 46
  2. Sodium 4 - (2H - naphtho (1,2 - d) triazol - 2 - yl) stilbene - 2 - sulfonate
  3. Sodium 2 - (4 - styryl - 3 - sulfophenyl) - 2H - naphtho - (1,2 - d) - triazole
  4. Tinopal RBS
  5. Tinopal RBS 200


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg moderate TXAPA9 27,494,1974
eye
rabbit 		100 mg/2S rinse mild TXAPA9 27,494,1974
eye
rabbit 		100 mg mild MVCRB3 2,193,1973
skin
rabbit 		500 mg/24 hour mild MVCRB3 2,193,1973


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 4,500 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Other changes 		TXAPA9 27,494,1974
oral
mouse 		lethal dose (50 percent kill): >10 gm/kg N/R TXAPA9 5,176,1963
oral
rat 		lethal dose (50 percent kill): >21,500 mg/kg N/R TXAPA9 5,176,1963
skin
rabbit 		lethal dose (50 percent kill): >2 gm/kg N/R MVCRB3 2,193,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 4,500 mg/kg/90 day- intermittent Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Peritonitis

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 27,494,1974


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0955;
Number of Industries 2;
Total Number of Facilities 141;
Number of Occupations 3;
Total Number of Employees Exposed 949


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
MVCRB3 MVC-Report. (Stockholm, Sweden) No.1-2, 1972-73. Discontinued.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a fluorescent whitening agent

RTECS Compound Description:
   Mutagen
   Primary Irritant

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