RTECS:CZ9370000 The Registry of Toxic Effects of Chemical Substances

Benzene, divinyl -

RTECS #: CZ9370000

CAS #: 1321-74-0

UPDATE: May 2009 MW: 130.20 MF: C₁₀H₁₀

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Benzene, diethenyl - (9CI)

Diethenylbenzene

Divinyl benzene

Divinyl benzene (ACGIH)

Divinylbenzene

Vinylstyrene

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis inhalation
mouse 53 ppm/6 hour/3 day- continuous MUREAV 370,107,1996
micronucleus test inhalation
mouse 53 ppm/6 hour/3 day- continuous MUREAV 370,107,1996
sister chromatid exchange inhalation
mouse 53 ppm/6 hour/3 day- continuous MUREAV 370,107,1996

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published lethal dose: 10 mL/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage AMIHAB 19,403,1959
oral
rat lethal dose (50 percent kill): 5 mL/kg N/R VCVGH* -,189,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse : 200 ppm/6 hour/2 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-534
inhalation
mouse : 100 ppm/6 hour/17 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-534
inhalation
mouse : 25 ppm/6 hour/17 day- intermittent Olfaction: Other olfaction effects

Endocrine: Changes in thymus weight NTPTR* NTP-TR-534
inhalation
mouse : 25 ppm/6 hour/17 day- intermittent Olfaction: Other olfaction effects

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight NTPTR* NTP-TR-534
inhalation
mouse : 200 ppm/6 hour/17 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Multiple effects

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) NTPTR* NTP-TR-534
inhalation
mouse : 200 ppm/6 hour/14 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-534
inhalation
mouse : 25 ppm/6 hour/14 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-534
inhalation
mouse : 100 ppm/6 hour/14 week- intermittent Behavioral: Sleep

Behavioral: Somnolence (general depressed activity) NTPTR* NTP-TR-534
inhalation
mouse : 100 ppm/6 hour/105 week- intermittent Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-534
inhalation
mouse : 30 ppm/6 hour/105 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-534
inhalation
mouse : 10 ppm/6 hour/105 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma NTPTR* NTP-TR-534
inhalation
mouse : 10 ppm/6 hour/105 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes NTPTR* NTP-TR-534
inhalation
rat : 400 ppm/6 hour/16 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-534
inhalation
rat : 50 ppm/6 hour/16 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight NTPTR* NTP-TR-534
inhalation
rat : 200 ppm/6 hour/16 day- intermittent Liver: Changes in liver weight NTPTR* NTP-TR-534
inhalation
rat : 100 ppm/6 hour/16 day- intermittent Olfaction: Other olfaction effects

Eye: Other eye effects NTPTR* NTP-TR-534
inhalation
rat : 50 ppm/6 hour/14 week- intermittent Olfaction: Other olfaction effects

Eye: Other eye effects NTPTR* NTP-TR-534
inhalation
rat : 25 ppm/6 hour/14 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight NTPTR* NTP-TR-534
inhalation
rat : 200 ppm/6 hour/14 week- intermittent Cardiac: Changes in heart weight

Related to Chronic Data: Changes in testicular weight NTPTR* NTP-TR-534
inhalation
rat : 100 ppm/6 hour/14 week- intermittent Olfaction: Other olfaction effects NTPTR* NTP-TR-534
inhalation
rat : 400 ppm/6 hour/105 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-534
inhalation
rat : 400 ppm/6 hour/53 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-534
inhalation
rat : 400 ppm/6 hour/105 week- intermittent Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Kidney tumors

Skin and Appendages: Tumors NTPTR* NTP-TR-534
inhalation
rat : 400 ppm/6 hour/105 week- intermittent Lung, Thorax, or Respiration: Other changes NTPTR* NTP-TR-534
inhalation
rat : 200 ppm/6 hour/105 week- intermittent Kidney, Ureter, and Bladder: Kidney tumors NTPTR* NTP-TR-534
inhalation
rat : 100 ppm/6 hour/105 week- intermittent Brain and Coverings: Tumors NTPTR* NTP-TR-534
inhalation
rat : 100 ppm/6 hour/105 week- intermittent Olfaction: Other olfaction effects NTPTR* NTP-TR-534

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2007

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (53 mg/m³), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (54 mg/m³), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (50 mg/m³), OCT 2002
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (50 mg/m³), 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (53 mg/m³), JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (50 mg/m³), DEC2006

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIVINYL BENZENE-air 10 hour time-weighted average 10 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83286;
Number of Industries 5;
Total Number of Facilities 164;
Number of Occupations 14;
Total Number of Employees Exposed 12,271
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83286;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 11

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000

REFERENCES:
CODEN
REFERENCE

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
Tumorigen
Mutagen

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SYNONYMS:
Benzene, diethenyl - (9CI) Diethenylbenzene Divinyl benzene	Divinyl benzene (ACGIH) Divinylbenzene Vinylstyrene

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	inhalation mouse	53 ppm/6 hour/3 day- continuous	MUREAV 370,107,1996
micronucleus test	inhalation mouse	53 ppm/6 hour/3 day- continuous	MUREAV 370,107,1996
sister chromatid exchange	inhalation mouse	53 ppm/6 hour/3 day- continuous	MUREAV 370,107,1996

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published lethal dose: 10 mL/kg	Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage	AMIHAB 19,403,1959
oral rat	lethal dose (50 percent kill): 5 mL/kg	N/R	VCVGH* -,189,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mouse	: 200 ppm/6 hour/2 day- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-534
inhalation mouse	: 100 ppm/6 hour/17 day- intermittent	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTPTR* NTP-TR-534
inhalation mouse	: 25 ppm/6 hour/17 day- intermittent	Olfaction: Other olfaction effects Endocrine: Changes in thymus weight	NTPTR* NTP-TR-534
inhalation mouse	: 25 ppm/6 hour/17 day- intermittent	Olfaction: Other olfaction effects Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	NTPTR* NTP-TR-534
inhalation mouse	: 200 ppm/6 hour/17 day- intermittent	Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Multiple effects Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	NTPTR* NTP-TR-534
inhalation mouse	: 200 ppm/6 hour/14 week- intermittent	Liver: Hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-534
inhalation mouse	: 25 ppm/6 hour/14 week- intermittent	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTPTR* NTP-TR-534
inhalation mouse	: 100 ppm/6 hour/14 week- intermittent	Behavioral: Sleep Behavioral: Somnolence (general depressed activity)	NTPTR* NTP-TR-534
inhalation mouse	: 100 ppm/6 hour/105 week- intermittent	Lung, Thorax, or Respiration: Tumors Lung, Thorax, or Respiration: Bronchogenic carcinoma Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTPTR* NTP-TR-534
inhalation mouse	: 30 ppm/6 hour/105 week- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTPTR* NTP-TR-534
inhalation mouse	: 10 ppm/6 hour/105 week- intermittent	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Tumors Lung, Thorax, or Respiration: Bronchogenic carcinoma	NTPTR* NTP-TR-534
inhalation mouse	: 10 ppm/6 hour/105 week- intermittent	Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Other changes	NTPTR* NTP-TR-534
inhalation rat	: 400 ppm/6 hour/16 day- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTPTR* NTP-TR-534
inhalation rat	: 50 ppm/6 hour/16 day- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight	NTPTR* NTP-TR-534
inhalation rat	: 200 ppm/6 hour/16 day- intermittent	Liver: Changes in liver weight	NTPTR* NTP-TR-534
inhalation rat	: 100 ppm/6 hour/16 day- intermittent	Olfaction: Other olfaction effects Eye: Other eye effects	NTPTR* NTP-TR-534
inhalation rat	: 50 ppm/6 hour/14 week- intermittent	Olfaction: Other olfaction effects Eye: Other eye effects	NTPTR* NTP-TR-534
inhalation rat	: 25 ppm/6 hour/14 week- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	NTPTR* NTP-TR-534
inhalation rat	: 200 ppm/6 hour/14 week- intermittent	Cardiac: Changes in heart weight Related to Chronic Data: Changes in testicular weight	NTPTR* NTP-TR-534
inhalation rat	: 100 ppm/6 hour/14 week- intermittent	Olfaction: Other olfaction effects	NTPTR* NTP-TR-534
inhalation rat	: 400 ppm/6 hour/105 week- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-534
inhalation rat	: 400 ppm/6 hour/53 week- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTPTR* NTP-TR-534
inhalation rat	: 400 ppm/6 hour/105 week- intermittent	Kidney, Ureter, and Bladder: Other changes Kidney, Ureter, and Bladder: Kidney tumors Skin and Appendages: Tumors	NTPTR* NTP-TR-534
inhalation rat	: 400 ppm/6 hour/105 week- intermittent	Lung, Thorax, or Respiration: Other changes	NTPTR* NTP-TR-534
inhalation rat	: 200 ppm/6 hour/105 week- intermittent	Kidney, Ureter, and Bladder: Kidney tumors	NTPTR* NTP-TR-534
inhalation rat	: 100 ppm/6 hour/105 week- intermittent	Brain and Coverings: Tumors	NTPTR* NTP-TR-534
inhalation rat	: 100 ppm/6 hour/105 week- intermittent	Olfaction: Other olfaction effects	NTPTR* NTP-TR-534

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 10 ppm	DTLVS* TLV/BEI,2007

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - AUSTRALIA	time-weighted average 10 ppm (53 mg/m³), JUL2008
Occupational Exposure Limit - BELGIUM	time-weighted average 10 ppm (54 mg/m³), MAR2002
Occupational Exposure Limit - DENMARK	time-weighted average 10 ppm (50 mg/m³), OCT 2002
Occupational Exposure Limit - KOREA	time-weighted average 10 ppm (50 mg/m³), 2006
Occupational Exposure Limit - NEW ZEALAND	time-weighted average 10 ppm (53 mg/m³), JAN2002
Occupational Exposure Limit - SWITZERLAND	MAK- week 10 ppm (50 mg/m³), DEC2006

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIVINYL BENZENE-air	10 hour time-weighted average 10 ppm	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 83286; Number of Industries 5; Total Number of Facilities 164; Number of Occupations 14; Total Number of Employees Exposed 12,271
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 83286; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 11

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000

REFERENCES:
CODEN	REFERENCE
AMIHAB	AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTPTR*	National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
VCVGH*	"Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.