CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Benzene, 1 - (1,1 - dimethylethyl) - 3,5 - dimethyl - 2,4,6 - trinitro -

RTECS #: CZ7210000

CAS #: 81-15-2

UPDATE: February 2008 MW: 297.30 MF: C12H15N3O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - (1,1 - Dimethylethyl) - 3,5 - dimethyl - 2,4,6 - trinitrobenzene
  2. 2,4,6 - Trinitro - 1,3 - dimethyl - 5 - tert - butylbenzene
  3. 2,4,6 - Trinitro - 3,5 - dimethyl - 1 - tert - butylbenzene
  4. 5 - tert - Butyl - 2,4,6 - trinitroxylene
  5. Benzene, 1 - tert - butyl - 3,5 - dimethyl - 2,4,6 - trinitro -
  1. Musk Xylene
  2. Musk xylol
  3. Xylene musk
  4. m - Xylene, 5 - tert - butyl - 2,4,6 - trinitro -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		5 mg/48 hour mild FCTXAV 13,881,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 660 mg/kg (7-17 day pregnant) Reproductive: Other effects on female TOLED5 111,169,1999
oral
rat 		lowest published toxic dose: 352 mg/kg (10 week male/10 week prior to copulation-2 week after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOLED5 115,73,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 36 gm/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Tumors 		FCTOD7 28,581,1990


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): >4 gm/kg N/R FCTOD7 28,581,1990
oral
rat 		lethal dose (50 percent kill): >10 gm/kg N/R BECTA6 26,656,1981
skin
rabbit 		lethal dose (50 percent kill): >15 gm/kg N/R BECTA6 26,656,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 5,040 mg/kg/14 day- continuous Behavioral: Tremor

Gastrointestinal: Ulceration or bleeding from stomach

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		ESKHA5 (108),89,1990
oral
mouse 		lowest published toxic dose: 21,420 mg/kg/17 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field ESKHA5 (108),89,1990
oral
mouse 		lowest published toxic dose: 140 mg/kg/7 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		TXAPA9 142,169,1997
oral
mouse 		lowest published toxic dose: 350 mg/kg/7 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXAPA9 142,169,1997
oral
rat 		lowest published toxic dose: 350 mg/kg/7 day- intermittent Liver: Changes in liver weight TOLED5 111,105,1999
oral
rat 		lowest published toxic dose: 490 mg/kg/10 week- continuous Liver: Other changes TOLED5 115,73,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 65,477,1996
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 65,477,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 65,477,1996
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83002;
Number of Industries 7;
Total Number of Facilities 463;
Number of Occupations 29;
Total Number of Employees Exposed 89,788
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83002;
Number of Industries 81;
Total Number of Facilities 9,459;
Number of Occupations 86;
Total Number of Employees Exposed 134,413;
Total Number of Female Employees Exposed 48,955


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a fixative for fragrance formulations

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Human Data
   Primary Irritant

 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us