RTECS:CU6125000 The Registry of Toxic Effects of Chemical Substances

Benzaldehyde, 3 - ethoxy - 4 - hydroxy -

RTECS #: CU6125000

CAS #: 121-32-4

UPDATE: February 2003 MW: 166.19 MF: C₉H₁₀O₃

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

MUTATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

3 - Ethoxy - 4 - hydroxybenzaldehyde

4 - Hydroxy - 3 - ethoxybenzaldehyde

Bourbonal

Ethavan

Ethovan

Ethyl vanillin

Ethylprotal

Protocatechuic aldehyde ethyl ether

Quantrovanil

Vanillal

Vanillin, ethyl -

Vanirom

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
human 10 mg/48 hour mild FCTXAV 13,103,1975

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis hamster fibroblast 250 mg/L FCTOD7 22,623,1984
sister chromatid exchange human lymphocyte 1 mmol/L MUREAV 206,17,1988

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
guinea pig lethal dose (50 percent kill): 1,140 mg/kg N/R COREAF 238,2576,1954
intraperitoneal
mouse lethal dose (50 percent kill): 750 mg/kg N/R CTOXAO 10,61,1977
intravenous
dog lowest published lethal dose: 760 mg/kg N/R COREAF 238,2576,1954
oral
rat lethal dose (50 percent kill): 1,590 mg/kg N/R FAONAU 44A,39,1967
oral
rabbit lowest published lethal dose: 3 gm/kg N/R JAPMA8 29,425,1940
subcutaneous
rat lowest published lethal dose: 1,800 mg/kg N/R JAPMA8 29,425,1940
skin
rabbit lethal dose (50 percent kill): >7,940 mg/kg N/R NTIS OTS0534355

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 4,480 mg/kg/70 day- intermittent Cardiac: Other changes

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPMA8 29,425,1940
oral
rat lowest published toxic dose: 28 gm/kg/2 week- intermittent Behavioral: Food intake (animal)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS OTS0540113
oral
rat lowest published toxic dose: 182 gm/kg/13 week- continuous Liver: Liver function tests impaired

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) NTIS** OTS0540703
oral
rat lowest published toxic dose: 4,480 mg/kg/70 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGK* -,399,1994

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4743;
Number of Industries 2;
Total Number of Facilities 26;
Number of Occupations 17;
Total Number of Employees Exposed 2,343
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4743;
Number of Industries 20;
Total Number of Facilities 2,917;
Number of Occupations 42;
Total Number of Employees Exposed 53,949;
Total Number of Female Employees Exposed 31,080

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as flavor and fragrance chemical
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as flavor and fragrance chemical

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

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SYNONYMS:
3 - Ethoxy - 4 - hydroxybenzaldehyde 4 - Hydroxy - 3 - ethoxybenzaldehyde Bourbonal Ethavan Ethovan Ethyl vanillin	Ethylprotal Protocatechuic aldehyde ethyl ether Quantrovanil Vanillal Vanillin, ethyl - Vanirom

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
skin human	10 mg/48 hour	mild	FCTXAV 13,103,1975

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	hamster fibroblast	250 mg/L	FCTOD7 22,623,1984
sister chromatid exchange	human lymphocyte	1 mmol/L	MUREAV 206,17,1988

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal guinea pig	lethal dose (50 percent kill): 1,140 mg/kg	N/R	COREAF 238,2576,1954
intraperitoneal mouse	lethal dose (50 percent kill): 750 mg/kg	N/R	CTOXAO 10,61,1977
intravenous dog	lowest published lethal dose: 760 mg/kg	N/R	COREAF 238,2576,1954
oral rat	lethal dose (50 percent kill): 1,590 mg/kg	N/R	FAONAU 44A,39,1967
oral rabbit	lowest published lethal dose: 3 gm/kg	N/R	JAPMA8 29,425,1940
subcutaneous rat	lowest published lethal dose: 1,800 mg/kg	N/R	JAPMA8 29,425,1940
skin rabbit	lethal dose (50 percent kill): >7,940 mg/kg	N/R	NTIS** OTS0534355

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 4,480 mg/kg/70 day- intermittent	Cardiac: Other changes Blood: Changes in spleen Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JAPMA8 29,425,1940
oral rat	lowest published toxic dose: 28 gm/kg/2 week- intermittent	Behavioral: Food intake (animal) Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0540113
oral rat	lowest published toxic dose: 182 gm/kg/13 week- continuous	Liver: Liver function tests impaired Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	NTIS** OTS0540703
oral rat	lowest published toxic dose: 4,480 mg/kg/70 day- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,399,1994

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: M4743; Number of Industries 2; Total Number of Facilities 26; Number of Occupations 17; Total Number of Employees Exposed 2,343
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: M4743; Number of Industries 20; Total Number of Facilities 2,917; Number of Occupations 42; Total Number of Employees Exposed 53,949; Total Number of Female Employees Exposed 31,080

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as flavor and fragrance chemical
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN	REFERENCE
COREAF	Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CTOXAO	Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
FAONAU	FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTOD7	Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV	Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JAPMA8	Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.