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Barbituric acid, 5 - ethyl - 5 - (1 - methylbutyl) - 2 - thio - , sodium salt

RTECS #: CQ6475000

CAS #: 71-73-8

UPDATE: November 2007 MW: 265.36 MF: C11H18N2O2S•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. 4,6 (1H,5H) - Pyrimidinedione, 5 - ethyldihydro - 5 - (1 - methylbutyl) - 2 - thioxo - , monosodium salt
  2. 5 - Ethyl - 5 - (1 - methylbutyl) - 2 - thiobarbituric acid monosodium
  3. Farmotal
  4. Hypnostan
  5. Intraval sodium
  6. Leopental
  7. Monosodium 5 - ethyl - 5 - (1 - methylbutyl) thiobarbiturate
  8. Nesdonal sodium
  9. Penthiobarbital sodium
  10. Pentothal sodium
  11. Ravonal
  12. Sodium 5 - ethyl - 5 - (1 - methylbutyl) - 2 - thiobarbiturate
  13. Sodium penthiobarbital
  14. Sodium pentothal
  15. Sodium pentothiobarbital
  1. Sodium thiopental
  2. Sodium thiopentobarbital
  3. Sodium thiopentone
  4. Soluble thiopentone
  5. Thiomebumal sodium
  6. Thionembutal
  7. Thiopental sodium
  8. Thiopental sodium salt
  9. Thiopentone sodium
  10. Thiothal sodium
  11. Thipental sodium
  12. Tiopental sodium
  13. Trapanal
  14. Trapanal sodium


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 50 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		OFAJAE 43,219,1967
intraperitoneal
mouse 		lowest published toxic dose: 75 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death OFAJAE 43,219,1967
subcutaneous
mouse 		lowest published toxic dose: 432 mg/kg (3-6 day pregnant) Reproductive: Effects on fertility: Other measures of fertility JOENAK 43,225,1969


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraarterial
human 		lowest published toxic dose: 7 mg/kg Vascular: Acute arterial occulsion

Vascular: Thromobosis distant from injection site 		LANCAO 2,571,1943
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 57,500 µg/kg N/R ANESAV 8,589,1947
intraperitoneal
mouse 		lethal dose (50 percent kill): 115 mg/kg N/R NIIRDN 6,457,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 28,410 µg/kg N/R JAPMA8 29,509,1940
intraperitoneal
rat 		lowest published lethal dose: 75 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		TXCYAC 202,165,2004
intraperitoneal
rat 		lowest published lethal dose: 75 mg/kg Behavioral: Coma

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis

Nutritional and Gross Metabolic: Body temperature decrease 		TXCYAC 218,22,2006
intraperitoneal
rat 		lethal dose (50 percent kill): 75 mg/kg Behavioral: Coma

Gastrointestinal: Decreased motility or constipation 		TXCYAC 224,184,2006
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg Nutritional and Gross Metabolic: Body temperature decrease

Nutritional and Gross Metabolic: Other changes 		TXCYAC 224,184,2006
intraperitoneal
rabbit 		lethal dose (50 percent kill): 35 mg/kg N/R NIIRDN 6,457,1982
intraperitoneal
rabbit 		lowest published toxic dose: 30 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Sleep 		FATOAO 50,23,1987
intravenous
cat 		lethal dose (50 percent kill): 32,500 µg/kg N/R PSEBAA 82,212,1953
intravenous
dog 		lethal dose (50 percent kill): 36 mg/kg N/R CRAAA7 29,89,1950
intravenous
mouse 		lethal dose (50 percent kill): 57 mg/kg N/R AIPTAK 105,221,1956
intravenous
rat 		lethal dose (50 percent kill): 43,600 µg/kg Behavioral: General anesthetic JPETAB 116,317,1956
intravenous
rabbit 		lethal dose (50 percent kill): 31 mg/kg N/R CRAAA7 29,89,1950
oral
dog 		lowest published lethal dose: 150 mg/kg N/R JPETAB 60,125,1937
oral
mouse 		lethal dose (50 percent kill): 208 mg/kg Behavioral: General anesthetic JPETAB 115,432,1955
oral
rat 		lethal dose (50 percent kill): 117 mg/kg Behavioral: General anesthetic JPETAB 115,432,1955
oral
rat 		lowest published toxic dose: 75 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		TOVEFN (1),11,2002
oral
rat 		lowest published toxic dose: 75 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Metabolism (intermediary): Lipids including transport 		TOVEFN (1),11,2002
rectal
human 		lowest published toxic dose: 45 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease

Behavioral: General anesthetic 		AACRAT 46,395,1967
rectal
rat 		lethal dose (50 percent kill): 102 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease

Behavioral: General anesthetic 		AACRAT 46,395,1967
rectal
woman 		lowest published toxic dose: 107 mg/kg Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Acute pulmonary edema 		CTOXAO 2,75,1969
subcutaneous
mouse 		lethal dose (50 percent kill): 225 mg/kg N/R TXAPA9 27,70,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
dog 		lowest published toxic dose: 750 mg/kg/30 day- intermittent Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 116,317,1956


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1306;
Number of Industries 1;
Total Number of Facilities 158;
Number of Occupations 6;
Total Number of Employees Exposed 2,048
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1306;
Number of Industries 1;
Total Number of Facilities 335;
Number of Occupations 6;
Total Number of Employees Exposed 5,619;
Total Number of Female Employees Exposed 4,042


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940-
CRAAA7 Current Researches in Anesthesia and Analgesia. (Cleveland, OH) V.1-35, 1922-56. For publisher information, see AACRAT.
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
OFAJAE Okajimas Folia Anatomica Japonica. (Keio Univ., School of Medicine, Dept. of Anatomy, 35 Shinano-machi, Shinjuku-ku, Tokyo 160, Japan) V.14- 1936-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as an intravenous anesthetic

FDA-proprietary drug

RTECS Compound Description:
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   Reproductive Effector
   Human Data

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