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Barbituric acid, 5 - ethyl - 5 - (1 - methylbutyl) - , sodium salt

RTECS #: CQ6125000

CAS #: 57-33-0

UPDATE: February 2009 MW: 249.30 MF: C11H18N2O3•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2,4,6 (1H,3H,5H) - Pyrimidinetrione, 5 - ethyl - 5 - (1 - methylbutyl) - , monosodium salt
  2. 5 - Ethyl - 5 - (1 - methylbutyl) - 2,4,6 (1H,3H,5H) - pyrimidinetrione monosodium salt
  3. 5 - Ethyl - 5 - (1 - methylbutyl) barbituric acid sodium salt
  4. Auropan
  5. Barpental
  6. Biosedan
  7. Butylmethyl ethyl malonyl urea sodium
  8. Butylone
  9. Carbrital
  10. Continal
  11. Diabutal
  12. Embutal
  13. Etaminal sodium
  14. Ethaminal sodium
  15. Euthatal
  16. Isobarb
  17. Mebubarbital sodium
  18. Mebumal natrium
  19. Mebumal sodium
  20. Mintal
  21. Napental
  22. Nembutal sodium
  23. Pacifan
  24. Palapent
  25. Penbar
  26. Pentabarbital sodium
  27. Pental
  1. Pentobarbital sodium
  2. Pentobarbitone sodium
  3. Pentonal
  4. Pentone
  5. Pentyl
  6. Propylmethylcarbinylethyl barbituric acid sodium salt
  7. Rivadorn
  8. Sagatal
  9. Sodium 5 - ethyl - 5 - (1 - methylbutyl) barbiturate
  10. Sodium ethaminal
  11. Sodium nembutal
  12. Sodium pentabarbital
  13. Sodium pentabarbitone
  14. Sodium pentobarbital
  15. Sodium pentobarbitone
  16. Sodium pentobarbiturate
  17. Sodium phenobarbital
  18. Sodium - Pent
  19. Soluble pentobarbital
  20. Somnopentyl
  21. Sonistan
  22. Sontobarbital nabitone
  23. Sopental
  24. Sotyl
  25. V - Pento
  26. Vetbutal


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis subcutaneous
hamster 		100 mg/kg AEHLAU 36,316,1981
dominant lethal test subcutaneous
hamster 		100 mg/kg AEHLAU 36,316,1981
DNA inhibition mouse other cell types 500 µmol/L BCPCA6 22,229,1973
DNA inhibition unreported route
mouse 		60 mg/kg FEPRA7 39,518,1980
micronucleus test intraperitoneal
mouse 		64,800 µg/kg IMSCE2 14,832,1986
other mutation test systems unreported route
mouse 		60 mg/kg FEPRA7 39,518,1980
other mutation test systems mouse other cell types 500 µmol/L BCPCA6 22,229,1973
other mutation test systems mouse lymphocyte 1,500 µmol/L BCPCA6 22,229,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lowest published toxic dose: 30 mg/kg (63 day pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		NEURAI 8,776,1958
intraperitoneal
guinea pig 		lowest published toxic dose: 28 mg/kg (63 day pregnant) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical 		NEURAI 8,776,1958
intraperitoneal
hamster 		lowest published toxic dose: 2,320 mg/kg (8-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 25(2),48A,1982
intraperitoneal
hamster 		lowest published toxic dose: 920 mg/kg (8-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 25(2),48A,1982
intraperitoneal
rat 		lowest published toxic dose: 22 mg/kg (10 day pregnant) Reproductive: Other effects to embryo or fetus RCOCB8 4,7,1972
intraperitoneal
rat 		lowest published toxic dose: 20 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility ENDOAO 84,1456,1969
intraperitoneal
rat 		lowest published toxic dose: 80 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) ENDOAO 84,1456,1969
intraperitoneal
rat 		lowest published toxic dose: 94,500 µg/kg (2 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		BIREBV 21,491,1979
intravenous
rabbit 		lowest published toxic dose: 40 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 18,773,1971
subcutaneous
hamster 		lowest published toxic dose: 100 mg/kg (1 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Effects on embryo or fetus: Fetal death 		AEHLAU 36,316,1981
subcutaneous
rat 		lowest published toxic dose: 520 mg/kg (9-21 day pregnant) Reproductive: Effects on newborn: Behavioral TJADAB 25(2),60A,1982
unreported route
rat 		lowest published toxic dose: 30 mg/kg (19 day pregnant) Reproductive: Effects on newborn: Behavioral JCPPAV 45,146,1952


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lethal dose (50 percent kill): 6,500 µg/kg N/R JPETAB 197,479,1976
intracerebral
mouse 		lowest published toxic dose: 4 mg/kg Peripheral Nerve and Sensation: Sensory change involving segmental distribution JPETAB 299,659,2001
intraduodenal
rat 		lethal dose (50 percent kill): 39 mg/kg N/R AIPTAK 180,155,1969
intramuscular
guinea pig 		lethal dose (50 percent kill): 70,300 µg/kg Behavioral: Sleep CANJAE 2,109,1955
intramuscular
mouse 		lethal dose (50 percent kill): 124 mg/kg N/R JPETAB 102,138,1951
intramuscular
pigeon 		lowest published toxic dose: 13 mg/kg Behavioral: Alteration of operant conditioning JPETAB 317,409,2006
intraperitoneal
cat 		lowest published lethal dose: 70 mg/kg N/R JPETAB 46,387,1932
intraperitoneal
chicken 		lethal dose (50 percent kill): 51,540 µg/kg N/R TXAPA9 2,558,1960
intraperitoneal
dog 		lowest published lethal dose: 50 mg/kg N/R 27ZIAQ -,181,1973
intraperitoneal
guinea pig 		lowest published lethal dose: 56 mg/kg N/R PSEBAA 33,527,1936
intraperitoneal
mouse 		lethal dose (50 percent kill): 126 mg/kg N/R JMCMAR 12,989,1969
intraperitoneal
mouse 		lowest published toxic dose: 25 mg/kg Kidney, Ureter, and Bladder: Urine volume increased JOETD7 79,13,2002
intraperitoneal
mouse 		lowest published toxic dose: 30 mg/kg Behavioral: General anesthetic PBBHAU 21,17,1984
intraperitoneal
mouse 		lowest published toxic dose: 17 mg/kg Behavioral: Change in psychophysiological tests JPETAB 314,675,2005
intraperitoneal
mouse 		lowest published toxic dose: 35 mg/kg Behavioral: Ataxia JPETAB 319,219,2006
intraperitoneal
mouse 		lowest published toxic dose: 30 mg/kg Behavioral: Sleep BMCPH* 3,3,2003
intraperitoneal
mouse 		lowest published toxic dose: 40 mg/kg Behavioral: Anticonvulsant

Behavioral: Sleep 		FTRPAE 76,187,2005
intraperitoneal
rat 		lethal dose (50 percent kill): 36 mg/kg N/R FCTXAV 3,597,1965
intraperitoneal
rat 		lowest published toxic dose: 35 mg/kg Behavioral: Sleep ENDOAO 106,343,1980
intraperitoneal
rat 		lowest published toxic dose: 3 mg/kg Behavioral: Alteration of operant conditioning PSCHDL 166,408,2003
intraperitoneal
rat 		lowest published toxic dose: 35 mg/kg Behavioral: Anticonvulsant NEROEW 28,1448,2003
intraperitoneal
rat 		lowest published toxic dose: 8.1 mg/kg Behavioral: Alteration of classical conditioning PBBHAU 43,1155,1992
intraperitoneal
rat 		lowest published toxic dose: 18 mg/kg Behavioral: Change in psychophysiological tests JPETAB 315,858,2005
intraperitoneal
rat 		lowest published toxic dose: 300 mg/kg Vascular: BP elevation not characterized in autonomic section

Vascular: BP lowering not characterized in autonomic section 		BJPCBM 145,567,2005
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg Reproductive: Maternal effects: Oogenesis REPRO* 125,597,2003
intraperitoneal
rabbit 		lethal dose (50 percent kill): 65 mg/kg N/R JPETAB 42,253,1931
intravenous
chicken 		lethal dose (50 percent kill): 48 mg/kg N/R TXAPA9 2,558,1960
intravenous
dog 		lowest published lethal dose: 50 mg/kg Behavioral: General anesthetic JPETAB 60,125,1937
intravenous
monkey 		lowest published toxic dose: 3.2 mg/kg Behavioral: Alteration of operant conditioning PSCHDL 163,477,2002
intravenous
mouse 		lethal dose (50 percent kill): 81 mg/kg N/R EJPHAZ 13,150,1971
intravenous
mouse 		lowest published toxic dose: 40 mg/kg Behavioral: Sleep BPBLEO 23,76,2000
intravenous
rat 		lethal dose (50 percent kill): 65 mg/kg N/R JPETAB 135,213,1962
intravenous
rabbit 		lethal dose (50 percent kill): 40 mg/kg N/R JAPMA8 44,221,1955
oral
wild bird 		lethal dose (50 percent kill): 75 mg/kg N/R TXAPA9 21,315,1972
oral
cat 		lethal dose (50 percent kill): 100 mg/kg Behavioral: General anesthetic

Behavioral: Excitement

Behavioral: Ataxia 		JPETAB 88,260,1946
oral
duck 		lethal dose (50 percent kill): 75 mg/kg N/R TXAPA9 21,315,1972
oral
dog 		lethal dose (50 percent kill): 65 mg/kg N/R JPETAB 80,119,1944
oral
guinea pig 		lethal dose (50 percent kill): 60 mg/kg N/R CLDND*
oral
man 		lowest published toxic dose: 6,430 µg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia

Behavioral: Antipsychotic 		JPETAB 197,488,1976
oral
mouse 		lethal dose (50 percent kill): 239 mg/kg N/R ARZNAD 31,2180,1981
oral
pigeon 		lethal dose (50 percent kill): 133 mg/kg N/R TXAPA9 21,315,1972
oral
rat 		lethal dose (50 percent kill): 118 mg/kg N/R TXAPA9 21,315,1972
oral
rabbit 		lethal dose (50 percent kill): 175 mg/kg N/R JPETAB 42,253,1931
oral
woman 		lowest published toxic dose: 60 mg/kg Behavioral: Wakefulness JLCMAK 29,265,1944
parenteral
rabbit 		lowest published lethal dose: 60 mg/kg Lung, Thorax, or Respiration: Respiratory depression JPETAB 41,465,1931
rectal
rabbit 		lowest published lethal dose: 65 mg/kg N/R JPETAB 60,189,1937
subcutaneous
guinea pig 		lethal dose (50 percent kill): 70 mg/kg Autonomic Nervous System: Parasympatholytic AIPTAK 137,375,1962
subcutaneous
monkey 		lowest published toxic dose: 13.49 mg/kg Behavioral: Alteration of operant conditioning JPETAB 300,1017,2002
subcutaneous
mouse 		lethal dose (50 percent kill): 122 mg/kg N/R TXAPA9 18,185,1971
subcutaneous
rat 		lethal dose (50 percent kill): 47 mg/kg N/R AIPTAK 180,155,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 40 mg/kg/2 day- intermittent Behavioral: Alteration of classical conditioning ACPSI* 24,1137,2003
intraperitoneal
rat 		lowest published toxic dose: 160 mg/kg/16 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field LBASAE 31,360,1981
oral
rat 		lowest published toxic dose: 441 mg/kg/4 day- intermittent Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		FAATDF 4,261,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TPHSDY 24,619,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1225;
Number of Industries 1;
Total Number of Facilities 58;
Number of Occupations 2;
Total Number of Employees Exposed 230
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1225;
Number of Industries 2;
Total Number of Facilities 593;
Number of Occupations 5;
Total Number of Employees Exposed 8,819;
Total Number of Female Employees Exposed 6,720


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
BMCPH* BioMedCentral Pharmacology (Biomed Central Ltd) -
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CANJAE Canadian Anaesthetists' Society Journal. (Toronto, Ont., Canada) V.1-33, 1954-86.
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FTRPAE Fitoterapia. (Inverni della Beffa SpA, via Ripamonti, 99, 20141 Milan, Italy) V.18- 1947-
IMSCE2 IRCS Medical Science. (Lancaster, UK) V.12-14, 1984-86. For publisher information, see MSCREJ.
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JCPPAV Journal of Comparative and Physiological Psychology. (Washington, DC) V.40-96, 1947-82.
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
LBASAE Laboratory Animal Science. (American Assoc. for Laboratory Animal Science, 210 N. Hammes Ave., Suite 205, Joliet, IL 60435) V.21- 1971-
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-
NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951-
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
REPRO*
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

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