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Barbituric acid, 5 - ethyl - 5 - isopentyl - , sodium salt

RTECS #: CQ5250000

CAS #: 64-43-7

UPDATE: February 2006 MW: 249.30 MF: C11H18N2O3•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. STANDARDS AND REGULATIONS:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. REFERENCES:

SYNONYMS:

  1. 5 - Ethyl - 5 - isopentylbarbituric acid sodium salt
  2. 5 - Ethyl - 5 - (3 - methylbutyl) barbituric acid sodium derivative
  3. 5 - Ethyl - 5 - (3 - methylbutyl) - 2,4,6 - (1H,3H,5H) - pyrimidinetrione sodium salt
  4. 5 - Isoamyl - 5 - ethylbarbituric acid, sodium deriv
  5. Alitinal
  6. Amobarbital sodium
  7. Amsebarb
  8. Amylobarbitone, sodium deriv
  9. Amytal sodium
  10. Barbamyl
  11. Barbituric acid, 5 - ethyl - 5 - isopentyl - , sodium deriv.
  1. Dorminal
  2. Drinamyl
  3. Dusotal
  4. Inmetal
  5. Sodium amobarbital
  6. Sodium amylobarbitone
  7. Sodium amytal
  8. Sodium barbamyl
  9. Sodium ethylisoamylbarbiturate
  10. Sodium isoamylethyl barbiturate
  11. t - Barb


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
cat 		lowest published lethal dose: 90 mg/kg N/R JPETAB 46,387,1932
intraperitoneal
guinea pig 		lowest published lethal dose: 120 mg/kg N/R JPHAA3 26,1248,1937
intraperitoneal
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R JPETAB 87,265,1946
intraperitoneal
rat 		lowest published lethal dose: 120 mg/kg N/R JACSAT 55,2979,1933
intraperitoneal
rat 		lowest published lethal dose: 100 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease 		TXCYAC 202,165,2004
intraperitoneal
rabbit 		lethal dose (50 percent kill): 90 mg/kg N/R JPETAB 42,253,1931
intravenous
cat 		lowest published lethal dose: 60 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: General anesthetic 		JPETAB 39,177,1930
intravenous
dog 		lethal dose (50 percent kill): 75 mg/kg Behavioral: General anesthetic

Behavioral: Tremor 		JAPMA8 44,152,1955
intravenous
guinea pig 		lowest published lethal dose: 90 mg/kg N/R JPHAA3 26,1248,1937
intravenous
mouse 		lowest published lethal dose: 200 mg/kg N/R JPHAA3 26,1248,1937
intravenous
rat 		lethal dose (50 percent kill): 128 mg/kg Behavioral: General anesthetic

Behavioral: Tremor 		JAPMA8 44,152,1955
intravenous
rabbit 		lethal dose (50 percent kill): 70 mg/kg Behavioral: General anesthetic

Behavioral: Tremor 		JAPMA8 44,152,1955
oral
dog 		lethal dose (50 percent kill): 99 mg/kg N/R JPETAB 68,22,1940
oral
frog 		lowest published lethal dose: 110 mg/kg N/R JPHAA3 26,1248,1937
oral
mouse 		lethal dose (50 percent kill): 505 mg/kg N/R FRPSAX 14,845,1959
oral
rat 		lethal dose (50 percent kill): 275 mg/kg N/R JPETAB 68,22,1940
oral
rabbit 		lethal dose (50 percent kill): 575 mg/kg N/R JPETAB 42,253,1931
rectal
dog 		lowest published lethal dose: 200 mg/kg N/R JPHAA3 26,1248,1937
subcutaneous
guinea pig 		lowest published lethal dose: 170 mg/kg N/R JPHAA3 26,1248,1937
subcutaneous
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R FATOAO 38,152,1975
subcutaneous
rat 		lowest published lethal dose: 90 mg/kg N/R JPETAB 31,1,1927
subcutaneous
rabbit 		lowest published lethal dose: 110 mg/kg N/R JPETAB 31,1,1927


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 (skin) DTLVS* 3,208,1971


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80515;
Number of Industries 2;
Total Number of Facilities 101;
Number of Occupations 7;
Total Number of Employees Exposed 3,694
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80515;
Number of Industries 1;
Total Number of Facilities 46;
Number of Occupations 1;
Total Number of Employees Exposed 620;
Total Number of Female Employees Exposed 417


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8
JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPHAA3 Journal of the American Pharmaceutical Association. (Washington, DC) V.1-28, 1912-39; New series: V.1-17, 1961-77.
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a hypnotic agent and, in veterinary medicine, as a sedative

RTECS Compound Description:
   Drug

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